First-trimester maternal renin-angiotensin-aldosterone system activation and the association with maternal telomere length after natural and IVF/ICSI conceived pregnancies: the Rotterdam periconception cohort
To study associations between the first-trimester maternal determinants of renin-angiotensin-aldosterone system (RAAS) activation and telomere length (TL) in pregnancies conceived natural and after IVF/ICSI. In 145 pregnancies of the Rotterdam Periconception cohort renin, prorenin and aldosterone co...
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| Veröffentlicht in: | Hypertension in pregnancy 2023-12, Vol.42 (1), p.2238086-2238086 |
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| container_title | Hypertension in pregnancy |
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| creator | Aoulad Fares, D. Wiegel, R.E. Eggink, A.J. van Meurs, J.B.J. Willemsen, S.P. Danser, A.H.J. Steegers-Theunissen, R.P.M. |
| description | To study associations between the first-trimester maternal determinants of renin-angiotensin-aldosterone system (RAAS) activation and telomere length (TL) in pregnancies conceived natural and after IVF/ICSI.
In 145 pregnancies of the Rotterdam Periconception cohort renin, prorenin and aldosterone concentrations were measured in maternal blood at 9 weeks gestational age (GA). TL was measured by qPCR at 20 weeks GA.
A significantly negative correlation was found between renin and TL, which was attenuated for prorenin but not observed for aldosterone. Maternal TL was significantly shorter in pregnancies conceived after in-vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) compared to natural pregnancies.
The negative association between first-trimester maternal renin and maternal TL, and the shorter maternal TL in women after IVF/ICSI treatment compared to natural pregnancies, substantiates the role of excessive RAAS activation. |
| doi_str_mv | 10.1080/10641955.2023.2238086 |
| format | Article |
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In 145 pregnancies of the Rotterdam Periconception cohort renin, prorenin and aldosterone concentrations were measured in maternal blood at 9 weeks gestational age (GA). TL was measured by qPCR at 20 weeks GA.
A significantly negative correlation was found between renin and TL, which was attenuated for prorenin but not observed for aldosterone. Maternal TL was significantly shorter in pregnancies conceived after in-vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) compared to natural pregnancies.
The negative association between first-trimester maternal renin and maternal TL, and the shorter maternal TL in women after IVF/ICSI treatment compared to natural pregnancies, substantiates the role of excessive RAAS activation.</description><identifier>ISSN: 1064-1955</identifier><identifier>EISSN: 1525-6065</identifier><identifier>DOI: 10.1080/10641955.2023.2238086</identifier><identifier>PMID: 37477196</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>aging ; Aldosterone ; Female ; Fertilization ; Fertilization in Vitro ; Humans ; inflammation ; Male ; oxidative stress ; Pregnancy ; Pregnancy Trimester, First ; Renin ; Renin-Angiotensin System ; Renin-angiotensin-aldosterone system ; Semen ; Sperm Injections, Intracytoplasmic ; Telomere ; telomere length</subject><ispartof>Hypertension in pregnancy, 2023-12, Vol.42 (1), p.2238086-2238086</ispartof><rights>2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c427t-737833a648e82f347c2502f7d6fc7f413a9719ce5e9a8e60a074801583e4b513</cites><orcidid>0000-0002-4353-5756</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/10641955.2023.2238086$$EPDF$$P50$$Ginformaworld$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/10641955.2023.2238086$$EHTML$$P50$$Ginformaworld$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,860,2096,27479,27901,27902,59116,59117</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37477196$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aoulad Fares, D.</creatorcontrib><creatorcontrib>Wiegel, R.E.</creatorcontrib><creatorcontrib>Eggink, A.J.</creatorcontrib><creatorcontrib>van Meurs, J.B.J.</creatorcontrib><creatorcontrib>Willemsen, S.P.</creatorcontrib><creatorcontrib>Danser, A.H.J.</creatorcontrib><creatorcontrib>Steegers-Theunissen, R.P.M.</creatorcontrib><title>First-trimester maternal renin-angiotensin-aldosterone system activation and the association with maternal telomere length after natural and IVF/ICSI conceived pregnancies: the Rotterdam periconception cohort</title><title>Hypertension in pregnancy</title><addtitle>Hypertens Pregnancy</addtitle><description>To study associations between the first-trimester maternal determinants of renin-angiotensin-aldosterone system (RAAS) activation and telomere length (TL) in pregnancies conceived natural and after IVF/ICSI.
In 145 pregnancies of the Rotterdam Periconception cohort renin, prorenin and aldosterone concentrations were measured in maternal blood at 9 weeks gestational age (GA). TL was measured by qPCR at 20 weeks GA.
A significantly negative correlation was found between renin and TL, which was attenuated for prorenin but not observed for aldosterone. Maternal TL was significantly shorter in pregnancies conceived after in-vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) compared to natural pregnancies.
The negative association between first-trimester maternal renin and maternal TL, and the shorter maternal TL in women after IVF/ICSI treatment compared to natural pregnancies, substantiates the role of excessive RAAS activation.</description><subject>aging</subject><subject>Aldosterone</subject><subject>Female</subject><subject>Fertilization</subject><subject>Fertilization in Vitro</subject><subject>Humans</subject><subject>inflammation</subject><subject>Male</subject><subject>oxidative stress</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, First</subject><subject>Renin</subject><subject>Renin-Angiotensin System</subject><subject>Renin-angiotensin-aldosterone system</subject><subject>Semen</subject><subject>Sperm Injections, Intracytoplasmic</subject><subject>Telomere</subject><subject>telomere length</subject><issn>1064-1955</issn><issn>1525-6065</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>EIF</sourceid><sourceid>DOA</sourceid><recordid>eNp9ks9uEzEQxlcIREvhEUB75LKp_-46nEBRA5EqIUHF1Zp4x4mrXTvYTqu8JY-EN0nLjYs9Gv_m-6TxV1XvKZlRosg1Ja2gcylnjDA-Y4wrotoX1SWVTDYtaeXLUhemmaCL6k1K94TQTgj5urrgneg6Om8vqz9LF1NucnQjpoyxHqGcHoY6one-Ab9xIaNPUz30YWKCxzodSjXWYLJ7gOyCr8H3dd5iDSkF4069R5e3_xQzDmHEiPWAflMewE6GHvI-ltdpfvVreb1a_FzVJniD7gH7ehdx48Ebh-nTUf9HyGWsh7HeYXRHcHc0M2EbYn5bvbIwJHx3vq-qu-XN3eJbc_v962rx5bYxgnW56XinOIdWKFTMctEZJgmzXd9a01lBOczLggxKnIPClgDphCJUKo5iLSm_qlYn2T7Avd6V9UE86ABOHxshbjTE7MyAei1Ma4WVxvBerBlCS3oFRApu16YFLFofT1q7GH7vyzfo0SWDwwAewz5ppgQlTEkmCipPqIkhpYj22ZoSPeVCP-VCT7nQ51yUuQ9ni_16xP556ikIBfh8Apy3IY7wGOLQ6wyHIUQbp_0nzf_v8Reu9M0u</recordid><startdate>20231231</startdate><enddate>20231231</enddate><creator>Aoulad Fares, D.</creator><creator>Wiegel, R.E.</creator><creator>Eggink, A.J.</creator><creator>van Meurs, J.B.J.</creator><creator>Willemsen, S.P.</creator><creator>Danser, A.H.J.</creator><creator>Steegers-Theunissen, R.P.M.</creator><general>Taylor & Francis</general><general>Taylor & Francis Group</general><scope>0YH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-4353-5756</orcidid></search><sort><creationdate>20231231</creationdate><title>First-trimester maternal renin-angiotensin-aldosterone system activation and the association with maternal telomere length after natural and IVF/ICSI conceived pregnancies: the Rotterdam periconception cohort</title><author>Aoulad Fares, D. ; Wiegel, R.E. ; Eggink, A.J. ; van Meurs, J.B.J. ; Willemsen, S.P. ; Danser, A.H.J. ; Steegers-Theunissen, R.P.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-737833a648e82f347c2502f7d6fc7f413a9719ce5e9a8e60a074801583e4b513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>aging</topic><topic>Aldosterone</topic><topic>Female</topic><topic>Fertilization</topic><topic>Fertilization in Vitro</topic><topic>Humans</topic><topic>inflammation</topic><topic>Male</topic><topic>oxidative stress</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, First</topic><topic>Renin</topic><topic>Renin-Angiotensin System</topic><topic>Renin-angiotensin-aldosterone system</topic><topic>Semen</topic><topic>Sperm Injections, Intracytoplasmic</topic><topic>Telomere</topic><topic>telomere length</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aoulad Fares, D.</creatorcontrib><creatorcontrib>Wiegel, R.E.</creatorcontrib><creatorcontrib>Eggink, A.J.</creatorcontrib><creatorcontrib>van Meurs, J.B.J.</creatorcontrib><creatorcontrib>Willemsen, S.P.</creatorcontrib><creatorcontrib>Danser, A.H.J.</creatorcontrib><creatorcontrib>Steegers-Theunissen, R.P.M.</creatorcontrib><collection>Taylor & Francis Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Hypertension in pregnancy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aoulad Fares, D.</au><au>Wiegel, R.E.</au><au>Eggink, A.J.</au><au>van Meurs, J.B.J.</au><au>Willemsen, S.P.</au><au>Danser, A.H.J.</au><au>Steegers-Theunissen, R.P.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>First-trimester maternal renin-angiotensin-aldosterone system activation and the association with maternal telomere length after natural and IVF/ICSI conceived pregnancies: the Rotterdam periconception cohort</atitle><jtitle>Hypertension in pregnancy</jtitle><addtitle>Hypertens Pregnancy</addtitle><date>2023-12-31</date><risdate>2023</risdate><volume>42</volume><issue>1</issue><spage>2238086</spage><epage>2238086</epage><pages>2238086-2238086</pages><issn>1064-1955</issn><eissn>1525-6065</eissn><abstract>To study associations between the first-trimester maternal determinants of renin-angiotensin-aldosterone system (RAAS) activation and telomere length (TL) in pregnancies conceived natural and after IVF/ICSI.
In 145 pregnancies of the Rotterdam Periconception cohort renin, prorenin and aldosterone concentrations were measured in maternal blood at 9 weeks gestational age (GA). TL was measured by qPCR at 20 weeks GA.
A significantly negative correlation was found between renin and TL, which was attenuated for prorenin but not observed for aldosterone. Maternal TL was significantly shorter in pregnancies conceived after in-vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) compared to natural pregnancies.
The negative association between first-trimester maternal renin and maternal TL, and the shorter maternal TL in women after IVF/ICSI treatment compared to natural pregnancies, substantiates the role of excessive RAAS activation.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>37477196</pmid><doi>10.1080/10641955.2023.2238086</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-4353-5756</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Taylor & Francis Open Access; MEDLINE; DOAJ Directory of Open Access Journals |
| subjects | aging Aldosterone Female Fertilization Fertilization in Vitro Humans inflammation Male oxidative stress Pregnancy Pregnancy Trimester, First Renin Renin-Angiotensin System Renin-angiotensin-aldosterone system Semen Sperm Injections, Intracytoplasmic Telomere telomere length |
| title | First-trimester maternal renin-angiotensin-aldosterone system activation and the association with maternal telomere length after natural and IVF/ICSI conceived pregnancies: the Rotterdam periconception cohort |
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