First-trimester maternal renin-angiotensin-aldosterone system activation and the association with maternal telomere length after natural and IVF/ICSI conceived pregnancies: the Rotterdam periconception cohort

To study associations between the first-trimester maternal determinants of renin-angiotensin-aldosterone system (RAAS) activation and telomere length (TL) in pregnancies conceived natural and after IVF/ICSI. In 145 pregnancies of the Rotterdam Periconception cohort renin, prorenin and aldosterone co...

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Veröffentlicht in:Hypertension in pregnancy 2023-12, Vol.42 (1), p.2238086-2238086
Hauptverfasser: Aoulad Fares, D., Wiegel, R.E., Eggink, A.J., van Meurs, J.B.J., Willemsen, S.P., Danser, A.H.J., Steegers-Theunissen, R.P.M.
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Sprache:eng
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Zusammenfassung:To study associations between the first-trimester maternal determinants of renin-angiotensin-aldosterone system (RAAS) activation and telomere length (TL) in pregnancies conceived natural and after IVF/ICSI. In 145 pregnancies of the Rotterdam Periconception cohort renin, prorenin and aldosterone concentrations were measured in maternal blood at 9 weeks gestational age (GA). TL was measured by qPCR at 20 weeks GA. A significantly negative correlation was found between renin and TL, which was attenuated for prorenin but not observed for aldosterone. Maternal TL was significantly shorter in pregnancies conceived after in-vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) compared to natural pregnancies. The negative association between first-trimester maternal renin and maternal TL, and the shorter maternal TL in women after IVF/ICSI treatment compared to natural pregnancies, substantiates the role of excessive RAAS activation.
ISSN:1064-1955
1525-6065
DOI:10.1080/10641955.2023.2238086