Celecoxib nanoemulsion: Skin permeation mechanism and bioavailability assessment

The aim of the present study was to assess the skin permeation mechanism and bioavailability of celecoxib (CXB) using novel nanoemulsion formulation. Fourier transform infrared spectra and differential scanning calorimetric thermogram of skin treated with nanoemulsion indicated that permeation occur...

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Veröffentlicht in:	Journal of drug targeting 2008-01, Vol.16 (10), p.733-740
Hauptverfasser:	Shakeel, Faiyaz, Baboota, Sanjula, Ahuja, Alka, Ali, Javed, Shafiq, Sheikh
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Administration, Topical Animals Area Under Curve bioavailability Biological and medical sciences Biological Availability Celecoxib Emulsions - chemistry General pharmacology Medical sciences nanoemulsion Nanostructures - chemistry Permeability Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Pyrazoles - administration & dosage Pyrazoles - blood Pyrazoles - pharmacokinetics Rats Skin - cytology Skin - drug effects Skin - metabolism skin permeation mechanism Sulfonamides - administration & dosage Sulfonamides - blood Sulfonamides - pharmacokinetics
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