Steroidal Saponins from the Rhizomes of Paris polyphylla var. chinensis and their Cytotoxic Activity on HL-60 Cells

Steroidal Saponins from the Rhizomes of Paris polyphylla var. chinensis and their Cytotoxic Activity on HL-60 Cells

A new spirostanol steroidal saponin, along with ten known saponins, which were based upon (25R)-spirost-5-en-3β-o1 (diosgenin) or (25R)-spirost-5-ene-3β5,17α-diol (pennogenin) as the aglycones, were isolated from the rhizomes of Paris polyphylla var. chinensis. Spectral data, including two-dimension...

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Veröffentlicht in:Natural product letters 2000-09, Vol.14 (5), p.357-364
Hauptverfasser: Mimaki, Yoshihiro, Kuroda, Minpei, Obata, Yuusuke, Sashida, Yutaka, Kitahara, Mikio, Yasuda, Akira, Naoi, Noriyuki, Xu, Zhen Wen, Li, Ming Run, Lao, Ai Na
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cytotoxic activity
HL-60 cells
Liliaceae
Paris polyphylla var. chinensis
spirostanol saponin
steroidal saponin
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container_end_page 364
container_issue 5
container_start_page 357
container_title Natural product letters
container_volume 14
creator Mimaki, Yoshihiro
Kuroda, Minpei
Obata, Yuusuke
Sashida, Yutaka
Kitahara, Mikio
Yasuda, Akira
Naoi, Noriyuki
Xu, Zhen Wen
Li, Ming Run
Lao, Ai Na
description A new spirostanol steroidal saponin, along with ten known saponins, which were based upon (25R)-spirost-5-en-3β-o1 (diosgenin) or (25R)-spirost-5-ene-3β5,17α-diol (pennogenin) as the aglycones, were isolated from the rhizomes of Paris polyphylla var. chinensis. Spectral data, including two-dimensional NMR, and the result of hydrolytic cleavage showed that the structure of the new saponin was pennogenin 3-0-{O−α-L-rhamnopyranosyl-(1→4)-O a-L-rhamnopyranosyl-(1→4)-β-D-glucopyranoside}. The isolated saponins were evaluated for their cytotoxic activity on human promyelocytic leukemia HL-60 cells.
doi_str_mv 10.1080/10575630008043768
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subjects cytotoxic activity
HL-60 cells
Liliaceae
Paris polyphylla var. chinensis
spirostanol saponin
steroidal saponin
title Steroidal Saponins from the Rhizomes of Paris polyphylla var. chinensis and their Cytotoxic Activity on HL-60 Cells
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