Osteoclast-like Cell Formation by Circulating Myeloma B Lymphocytes: Role of RANK-L

Excessive bone resorption in multiple myeloma (MM), a malignancy of B lymphoid origin, is mediated through osteoclasts, which respond to local osteoclast-activating factors produced by tumor cells within the bone marrow microenvironment. Direct bone resorption by myeloma cells is investigated in the...

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Veröffentlicht in:	Leukemia & lymphoma 2004-02, Vol.45 (2), p.377-380
Hauptverfasser:	CALVANI, NICOLA, SILVESTRIS, FRANCO, CAFFORIO, PAOLA, DAMMACCO, FRANCO
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antigens, CD19 - biosynthesis B lymphocytes B-Lymphocytes - metabolism Bone Resorption Carrier Proteins - metabolism Case-Control Studies Cell Division Cells, Cultured Humans Leukocytes, Mononuclear - metabolism Macrophage Colony-Stimulating Factor - metabolism Membrane Glycoproteins - metabolism Middle Aged multiple myeloma Multiple Myeloma - metabolism Neoplastic Cells, Circulating osteoclasts Osteoclasts - metabolism Phenotype RANK Ligand RANK-L Receptor Activator of Nuclear Factor-kappa B Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism TRAP
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