Antioxidant effect of saponin: potential action of a soybean flavonoid on glucose tolerance and risk factors for atherosclerosis
At the present time, much attention is being paid to antioxidant substances because many pathological conditions are associated with oxidative stress. The purpose of the present study was to discover the potency of saponin (2-phenyl-benzopyrane), a soybean flavonoid, with respect to its hypoglycaemi...
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| Veröffentlicht in: | International journal of food sciences and nutrition 2005-03, Vol.56 (2), p.79-85 |
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| container_title | International journal of food sciences and nutrition |
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| creator | Rodrigues, H.G Diniz, Y.S Faine, L.A Galhardi, C.M Burneiko, R.C Almeida, J.A Ribas, B.O Novelli, E.L.B |
| description | At the present time, much attention is being paid to antioxidant substances because many pathological conditions are associated with oxidative stress. The purpose of the present study was to discover the potency of saponin (2-phenyl-benzopyrane), a soybean flavonoid, with respect to its hypoglycaemic and hypolipidaemic action, and the association of these effects with oxidative stress. Male Wistar rats were divided into two groups (n=6): control group and saponin-treated group (60 mg/kg) during 30 days. Saponin had no effects on glucose tolerance. Although no changes had been observed in low-density lipoprotein-cholesterol, saponin-treated animals had increased low-density lipoprotein-cholesterol/triacylglycerol ratio and decreased triacylglycerol, very low-density lipoprotein-cholesterol and total/high-density lipoprotein-cholesterol ratio than the control group. Saponin-treated rats showed lower lipid hydroperoxide than control rats, indicating decreased potential to atherosclerosis. No alterations were observed in antioxidant enzymes, superoxide dismutase and glutathione peroxidase, while lipid hydroperoxide were decreased in saponin-treated rats. In conclusion, the beneficial effects of saponin on serum lipids were related to a direct saponin antioxidant activity. |
| doi_str_mv | 10.1080/09637480500081738 |
| format | Article |
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The purpose of the present study was to discover the potency of saponin (2-phenyl-benzopyrane), a soybean flavonoid, with respect to its hypoglycaemic and hypolipidaemic action, and the association of these effects with oxidative stress. Male Wistar rats were divided into two groups (n=6): control group and saponin-treated group (60 mg/kg) during 30 days. Saponin had no effects on glucose tolerance. Although no changes had been observed in low-density lipoprotein-cholesterol, saponin-treated animals had increased low-density lipoprotein-cholesterol/triacylglycerol ratio and decreased triacylglycerol, very low-density lipoprotein-cholesterol and total/high-density lipoprotein-cholesterol ratio than the control group. Saponin-treated rats showed lower lipid hydroperoxide than control rats, indicating decreased potential to atherosclerosis. No alterations were observed in antioxidant enzymes, superoxide dismutase and glutathione peroxidase, while lipid hydroperoxide were decreased in saponin-treated rats. In conclusion, the beneficial effects of saponin on serum lipids were related to a direct saponin antioxidant activity.</description><identifier>ISSN: 0963-7486</identifier><identifier>EISSN: 1465-3478</identifier><identifier>DOI: 10.1080/09637480500081738</identifier><identifier>PMID: 16019317</identifier><language>eng</language><publisher>Basingstoke: Informa UK Ltd</publisher><subject>2-phenyl-benzopirane ; animal models ; Animals ; antioxidant activity ; Antioxidants ; Antioxidants - pharmacology ; Arteriosclerosis - etiology ; atherosclerosis ; Biological and medical sciences ; Biomarkers - blood ; blood lipids ; Cereal and baking product industries ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Cholesterol, VLDL - blood ; diet-related diseases ; flavonoids ; Flavonoids - pharmacology ; Food industries ; Food science ; Fundamental and applied biological sciences. Psychology ; Glucose ; Glucose - metabolism ; glucose tolerance ; glycemic effect ; Glycine max - chemistry ; hypolipidemia ; lipemic effect ; lipid peroxidation ; Lipid Peroxides - blood ; Male ; oxidative stress ; Oxidative Stress - drug effects ; Rats ; Risk Factors ; saponins ; Saponins - pharmacology ; Soybeans ; Triglycerides - blood</subject><ispartof>International journal of food sciences and nutrition, 2005-03, Vol.56 (2), p.79-85</ispartof><rights>2005 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2005</rights><rights>2005 INIST-CNRS</rights><rights>Copyright Carfax Publishing Company Mar 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c551t-e34b82a0911aaf385746932ae3f2bb7a889fc07cb13ddf8c41fb8f5ca013cdaf3</citedby><cites>FETCH-LOGICAL-c551t-e34b82a0911aaf385746932ae3f2bb7a889fc07cb13ddf8c41fb8f5ca013cdaf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/09637480500081738$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/09637480500081738$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,59620,60409,61194,61375</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16892614$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16019317$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rodrigues, H.G</creatorcontrib><creatorcontrib>Diniz, Y.S</creatorcontrib><creatorcontrib>Faine, L.A</creatorcontrib><creatorcontrib>Galhardi, C.M</creatorcontrib><creatorcontrib>Burneiko, R.C</creatorcontrib><creatorcontrib>Almeida, J.A</creatorcontrib><creatorcontrib>Ribas, B.O</creatorcontrib><creatorcontrib>Novelli, E.L.B</creatorcontrib><title>Antioxidant effect of saponin: potential action of a soybean flavonoid on glucose tolerance and risk factors for atherosclerosis</title><title>International journal of food sciences and nutrition</title><addtitle>Int J Food Sci Nutr</addtitle><description>At the present time, much attention is being paid to antioxidant substances because many pathological conditions are associated with oxidative stress. The purpose of the present study was to discover the potency of saponin (2-phenyl-benzopyrane), a soybean flavonoid, with respect to its hypoglycaemic and hypolipidaemic action, and the association of these effects with oxidative stress. Male Wistar rats were divided into two groups (n=6): control group and saponin-treated group (60 mg/kg) during 30 days. Saponin had no effects on glucose tolerance. Although no changes had been observed in low-density lipoprotein-cholesterol, saponin-treated animals had increased low-density lipoprotein-cholesterol/triacylglycerol ratio and decreased triacylglycerol, very low-density lipoprotein-cholesterol and total/high-density lipoprotein-cholesterol ratio than the control group. Saponin-treated rats showed lower lipid hydroperoxide than control rats, indicating decreased potential to atherosclerosis. No alterations were observed in antioxidant enzymes, superoxide dismutase and glutathione peroxidase, while lipid hydroperoxide were decreased in saponin-treated rats. In conclusion, the beneficial effects of saponin on serum lipids were related to a direct saponin antioxidant activity.</description><subject>2-phenyl-benzopirane</subject><subject>animal models</subject><subject>Animals</subject><subject>antioxidant activity</subject><subject>Antioxidants</subject><subject>Antioxidants - pharmacology</subject><subject>Arteriosclerosis - etiology</subject><subject>atherosclerosis</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>blood lipids</subject><subject>Cereal and baking product industries</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>Cholesterol, VLDL - blood</subject><subject>diet-related diseases</subject><subject>flavonoids</subject><subject>Flavonoids - pharmacology</subject><subject>Food industries</subject><subject>Food science</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glucose</subject><subject>Glucose - metabolism</subject><subject>glucose tolerance</subject><subject>glycemic effect</subject><subject>Glycine max - chemistry</subject><subject>hypolipidemia</subject><subject>lipemic effect</subject><subject>lipid peroxidation</subject><subject>Lipid Peroxides - blood</subject><subject>Male</subject><subject>oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Rats</subject><subject>Risk Factors</subject><subject>saponins</subject><subject>Saponins - pharmacology</subject><subject>Soybeans</subject><subject>Triglycerides - blood</subject><issn>0963-7486</issn><issn>1465-3478</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2PFCEQhonRuOPqD_CixERvrdB0A61eNhu_kk086J5JNQ07rAyMQLs7N3-6dGbM-pHspTjU81SoehF6TMlLSiR5RQbORCdJTwiRVDB5B61ox_uGdULeRaul31SAH6EHOV9WivZC3EdHlBM6MCpW6OdJKC5euwlCwcZaowuOFmfYxuDCa7yNxVQCPAZdwbA0Aee4Gw0EbD38iCG6CdfOhZ91zAaX6E2CoA2GMOHk8jdsqxxTxjYmDGVtUszaL9Xlh-ieBZ_No8N7jM7fv_t6-rE5-_zh0-nJWaP7npbGsG6ULZCBUgDLZC86PrAWDLPtOAqQcrCaCD1SNk1W6o7aUdpeA6FMT9U4Ri_2c7cpfp9NLmrjsjbeQzBxzopLwgTvSQWf_QNexjmF-jfVUt5JSQZZIbqHdF0iJ2PVNrkNpJ2iRC3ZqP-yqc6Tw-B53JjpxjiEUYHnBwCyBm-XI7r8ByeHltOucm_3nAv1oBu4islPqsDOx_RbYrf9481f-tqAL2sNydxsepv9dG9biAouarzq_Etbr0zoUqRgvwD1Ycc1</recordid><startdate>20050301</startdate><enddate>20050301</enddate><creator>Rodrigues, H.G</creator><creator>Diniz, Y.S</creator><creator>Faine, L.A</creator><creator>Galhardi, C.M</creator><creator>Burneiko, R.C</creator><creator>Almeida, J.A</creator><creator>Ribas, B.O</creator><creator>Novelli, E.L.B</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Nature Publishing</general><general>Taylor & Francis Ltd</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T7</scope><scope>7TS</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20050301</creationdate><title>Antioxidant effect of saponin: potential action of a soybean flavonoid on glucose tolerance and risk factors for atherosclerosis</title><author>Rodrigues, H.G ; Diniz, Y.S ; Faine, L.A ; Galhardi, C.M ; Burneiko, R.C ; Almeida, J.A ; Ribas, B.O ; Novelli, E.L.B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c551t-e34b82a0911aaf385746932ae3f2bb7a889fc07cb13ddf8c41fb8f5ca013cdaf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>2-phenyl-benzopirane</topic><topic>animal models</topic><topic>Animals</topic><topic>antioxidant activity</topic><topic>Antioxidants</topic><topic>Antioxidants - pharmacology</topic><topic>Arteriosclerosis - etiology</topic><topic>atherosclerosis</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>blood lipids</topic><topic>Cereal and baking product industries</topic><topic>Cholesterol, HDL - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>Cholesterol, VLDL - blood</topic><topic>diet-related diseases</topic><topic>flavonoids</topic><topic>Flavonoids - pharmacology</topic><topic>Food industries</topic><topic>Food science</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glucose</topic><topic>Glucose - metabolism</topic><topic>glucose tolerance</topic><topic>glycemic effect</topic><topic>Glycine max - chemistry</topic><topic>hypolipidemia</topic><topic>lipemic effect</topic><topic>lipid peroxidation</topic><topic>Lipid Peroxides - blood</topic><topic>Male</topic><topic>oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Rats</topic><topic>Risk Factors</topic><topic>saponins</topic><topic>Saponins - pharmacology</topic><topic>Soybeans</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rodrigues, H.G</creatorcontrib><creatorcontrib>Diniz, Y.S</creatorcontrib><creatorcontrib>Faine, L.A</creatorcontrib><creatorcontrib>Galhardi, C.M</creatorcontrib><creatorcontrib>Burneiko, R.C</creatorcontrib><creatorcontrib>Almeida, J.A</creatorcontrib><creatorcontrib>Ribas, B.O</creatorcontrib><creatorcontrib>Novelli, E.L.B</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of food sciences and nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rodrigues, H.G</au><au>Diniz, Y.S</au><au>Faine, L.A</au><au>Galhardi, C.M</au><au>Burneiko, R.C</au><au>Almeida, J.A</au><au>Ribas, B.O</au><au>Novelli, E.L.B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antioxidant effect of saponin: potential action of a soybean flavonoid on glucose tolerance and risk factors for atherosclerosis</atitle><jtitle>International journal of food sciences and nutrition</jtitle><addtitle>Int J Food Sci Nutr</addtitle><date>2005-03-01</date><risdate>2005</risdate><volume>56</volume><issue>2</issue><spage>79</spage><epage>85</epage><pages>79-85</pages><issn>0963-7486</issn><eissn>1465-3478</eissn><abstract>At the present time, much attention is being paid to antioxidant substances because many pathological conditions are associated with oxidative stress. The purpose of the present study was to discover the potency of saponin (2-phenyl-benzopyrane), a soybean flavonoid, with respect to its hypoglycaemic and hypolipidaemic action, and the association of these effects with oxidative stress. Male Wistar rats were divided into two groups (n=6): control group and saponin-treated group (60 mg/kg) during 30 days. Saponin had no effects on glucose tolerance. Although no changes had been observed in low-density lipoprotein-cholesterol, saponin-treated animals had increased low-density lipoprotein-cholesterol/triacylglycerol ratio and decreased triacylglycerol, very low-density lipoprotein-cholesterol and total/high-density lipoprotein-cholesterol ratio than the control group. Saponin-treated rats showed lower lipid hydroperoxide than control rats, indicating decreased potential to atherosclerosis. No alterations were observed in antioxidant enzymes, superoxide dismutase and glutathione peroxidase, while lipid hydroperoxide were decreased in saponin-treated rats. In conclusion, the beneficial effects of saponin on serum lipids were related to a direct saponin antioxidant activity.</abstract><cop>Basingstoke</cop><pub>Informa UK Ltd</pub><pmid>16019317</pmid><doi>10.1080/09637480500081738</doi><tpages>7</tpages></addata></record> |
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| ispartof | International journal of food sciences and nutrition, 2005-03, Vol.56 (2), p.79-85 |
| issn | 0963-7486 1465-3478 |
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| source | Taylor & Francis; MEDLINE |
| subjects | 2-phenyl-benzopirane animal models Animals antioxidant activity Antioxidants Antioxidants - pharmacology Arteriosclerosis - etiology atherosclerosis Biological and medical sciences Biomarkers - blood blood lipids Cereal and baking product industries Cholesterol, HDL - blood Cholesterol, LDL - blood Cholesterol, VLDL - blood diet-related diseases flavonoids Flavonoids - pharmacology Food industries Food science Fundamental and applied biological sciences. Psychology Glucose Glucose - metabolism glucose tolerance glycemic effect Glycine max - chemistry hypolipidemia lipemic effect lipid peroxidation Lipid Peroxides - blood Male oxidative stress Oxidative Stress - drug effects Rats Risk Factors saponins Saponins - pharmacology Soybeans Triglycerides - blood |
| title | Antioxidant effect of saponin: potential action of a soybean flavonoid on glucose tolerance and risk factors for atherosclerosis |
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