Inactivation and Mutation Induction in V79 Cells by Low Energy Protons: Re-evaluation of the Results at the LNL Facility
During the upgrading of the radiobiological facility at the Laboratori Nazionali di Legnaro (LNL) we found that uncorrected values of the proton energy were used in the past. This circumstance prompted us to perform the reevaluation of the physical parameters for all the proton beams used in our pre...
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Veröffentlicht in: | International journal of radiation biology 1993, Vol.63 (3), p.331-337 |
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container_title | International journal of radiation biology |
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creator | Belli, M. Cera, F. Cherubini, R. Haque, A.M.I. Ianzini, F. Moschini, G. Sapora, O. Simone, G. Tabocchini, M.A. Tiveron, P. |
description | During the upgrading of the radiobiological facility at the Laboratori Nazionali di Legnaro (LNL) we found that uncorrected values of the proton energy were used in the past. This circumstance prompted us to perform the reevaluation of the physical parameters for all the proton beams used in our previous radiobiological investigations (Belli et al. 1987) and, subsequently, the re-evaluation of all our previous dose-response curves for inactivation and mutation induction (Belli et al. 1989, 1991). This re-evaluation leads to significant changes in the dose-response curves and in the RBE-LET relationships only at the two lowest energies (highest LET) used. These two points are not reliable for the identification of a peak in RBE-LET relationship for cell inactivation. In spite of that, the extent of the changes is not such as to modify the general conclusion previously drawn, pointing out that there is a LET range where protons are more effective than alpha-particles. |
doi_str_mv | 10.1080/09553009314550441 |
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This circumstance prompted us to perform the reevaluation of the physical parameters for all the proton beams used in our previous radiobiological investigations (Belli et al. 1987) and, subsequently, the re-evaluation of all our previous dose-response curves for inactivation and mutation induction (Belli et al. 1989, 1991). This re-evaluation leads to significant changes in the dose-response curves and in the RBE-LET relationships only at the two lowest energies (highest LET) used. These two points are not reliable for the identification of a peak in RBE-LET relationship for cell inactivation. In spite of that, the extent of the changes is not such as to modify the general conclusion previously drawn, pointing out that there is a LET range where protons are more effective than alpha-particles.</description><identifier>ISSN: 0955-3002</identifier><identifier>EISSN: 1362-3095</identifier><identifier>DOI: 10.1080/09553009314550441</identifier><identifier>PMID: 8095283</identifier><language>eng</language><publisher>London: Informa UK Ltd</publisher><subject>Animals ; Applied radiobiology (equipment, dosimetry...) ; Biological and medical sciences ; Biological effects of radiation ; Cell Line ; Cell Survival - radiation effects ; Cells, Cultured - radiation effects ; Cricetinae ; Dosage Compensation, Genetic ; Dose-Response Relationship, Radiation ; Energy Transfer ; Fundamental and applied biological sciences. Psychology ; Italy ; Laboratories ; Mutagenesis ; Protons ; Radiation Genetics ; Relative Biological Effectiveness ; Tissues, organs and organisms biophysics</subject><ispartof>International journal of radiation biology, 1993, Vol.63 (3), p.331-337</ispartof><rights>1993 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1993</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-24ea3bd0ef543867e132d058bcc1518f2578e7e3c5829ab5098f2ecae450e4853</citedby><cites>FETCH-LOGICAL-c411t-24ea3bd0ef543867e132d058bcc1518f2578e7e3c5829ab5098f2ecae450e4853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/09553009314550441$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/09553009314550441$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>315,781,785,4025,27928,27929,27930,59652,59758,60441,60547,61226,61261,61407,61442</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4624865$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8095283$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Belli, M.</creatorcontrib><creatorcontrib>Cera, F.</creatorcontrib><creatorcontrib>Cherubini, R.</creatorcontrib><creatorcontrib>Haque, A.M.I.</creatorcontrib><creatorcontrib>Ianzini, F.</creatorcontrib><creatorcontrib>Moschini, G.</creatorcontrib><creatorcontrib>Sapora, O.</creatorcontrib><creatorcontrib>Simone, G.</creatorcontrib><creatorcontrib>Tabocchini, M.A.</creatorcontrib><creatorcontrib>Tiveron, P.</creatorcontrib><title>Inactivation and Mutation Induction in V79 Cells by Low Energy Protons: Re-evaluation of the Results at the LNL Facility</title><title>International journal of radiation biology</title><addtitle>Int J Radiat Biol</addtitle><description>During the upgrading of the radiobiological facility at the Laboratori Nazionali di Legnaro (LNL) we found that uncorrected values of the proton energy were used in the past. This circumstance prompted us to perform the reevaluation of the physical parameters for all the proton beams used in our previous radiobiological investigations (Belli et al. 1987) and, subsequently, the re-evaluation of all our previous dose-response curves for inactivation and mutation induction (Belli et al. 1989, 1991). This re-evaluation leads to significant changes in the dose-response curves and in the RBE-LET relationships only at the two lowest energies (highest LET) used. These two points are not reliable for the identification of a peak in RBE-LET relationship for cell inactivation. In spite of that, the extent of the changes is not such as to modify the general conclusion previously drawn, pointing out that there is a LET range where protons are more effective than alpha-particles.</description><subject>Animals</subject><subject>Applied radiobiology (equipment, dosimetry...)</subject><subject>Biological and medical sciences</subject><subject>Biological effects of radiation</subject><subject>Cell Line</subject><subject>Cell Survival - radiation effects</subject><subject>Cells, Cultured - radiation effects</subject><subject>Cricetinae</subject><subject>Dosage Compensation, Genetic</subject><subject>Dose-Response Relationship, Radiation</subject><subject>Energy Transfer</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Italy</subject><subject>Laboratories</subject><subject>Mutagenesis</subject><subject>Protons</subject><subject>Radiation Genetics</subject><subject>Relative Biological Effectiveness</subject><subject>Tissues, organs and organisms biophysics</subject><issn>0955-3002</issn><issn>1362-3095</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9v1DAQxS1EVbaFD8AByQeuKXZs7zrABa36Z6UUEAKu0cSZsKm8dmU7Lfn2eJulEkLqyW_mzW9sP0Jec3bGmWbvWKWUYKwSXCrFpOTPyIKLZVmI7Dwni72fNStfkJMYb1hWTOhjcqyzU2qxIL83Dkwa7iAN3lFwHb0e01xsXDeaBzU4-nNV0TVaG2k70drf03OH4ddEvwafvIvv6Tcs8A7sOLO-p2mLuRlHmyKF9FDWn2t6AWawQ5pekqMebMRXh_OU_Lg4_76-Kuovl5v1p7owkvNUlBJBtB3DXkmhlyvkouyY0q0xXHHdl2qlcYXCKF1W0CpW5R4aQKkYSq3EKeHzXhN8jAH75jYMOwhTw1mzD7H5L8TMvJmZ27HdYfdIHFLL_tuDD9GA7QM4M8THMbkspV7ur_44jw2u92EH9z7YrkkwWR_-MuKpV3z4B98i2LQ1ELC58WNwObUn_vAHc--d-w</recordid><startdate>1993</startdate><enddate>1993</enddate><creator>Belli, M.</creator><creator>Cera, F.</creator><creator>Cherubini, R.</creator><creator>Haque, A.M.I.</creator><creator>Ianzini, F.</creator><creator>Moschini, G.</creator><creator>Sapora, O.</creator><creator>Simone, G.</creator><creator>Tabocchini, M.A.</creator><creator>Tiveron, P.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1993</creationdate><title>Inactivation and Mutation Induction in V79 Cells by Low Energy Protons: Re-evaluation of the Results at the LNL Facility</title><author>Belli, M. ; Cera, F. ; Cherubini, R. ; Haque, A.M.I. ; Ianzini, F. ; Moschini, G. ; Sapora, O. ; Simone, G. ; Tabocchini, M.A. ; Tiveron, P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-24ea3bd0ef543867e132d058bcc1518f2578e7e3c5829ab5098f2ecae450e4853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Applied radiobiology (equipment, dosimetry...)</topic><topic>Biological and medical sciences</topic><topic>Biological effects of radiation</topic><topic>Cell Line</topic><topic>Cell Survival - radiation effects</topic><topic>Cells, Cultured - radiation effects</topic><topic>Cricetinae</topic><topic>Dosage Compensation, Genetic</topic><topic>Dose-Response Relationship, Radiation</topic><topic>Energy Transfer</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Italy</topic><topic>Laboratories</topic><topic>Mutagenesis</topic><topic>Protons</topic><topic>Radiation Genetics</topic><topic>Relative Biological Effectiveness</topic><topic>Tissues, organs and organisms biophysics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Belli, M.</creatorcontrib><creatorcontrib>Cera, F.</creatorcontrib><creatorcontrib>Cherubini, R.</creatorcontrib><creatorcontrib>Haque, A.M.I.</creatorcontrib><creatorcontrib>Ianzini, F.</creatorcontrib><creatorcontrib>Moschini, G.</creatorcontrib><creatorcontrib>Sapora, O.</creatorcontrib><creatorcontrib>Simone, G.</creatorcontrib><creatorcontrib>Tabocchini, M.A.</creatorcontrib><creatorcontrib>Tiveron, P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>International journal of radiation biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Belli, M.</au><au>Cera, F.</au><au>Cherubini, R.</au><au>Haque, A.M.I.</au><au>Ianzini, F.</au><au>Moschini, G.</au><au>Sapora, O.</au><au>Simone, G.</au><au>Tabocchini, M.A.</au><au>Tiveron, P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inactivation and Mutation Induction in V79 Cells by Low Energy Protons: Re-evaluation of the Results at the LNL Facility</atitle><jtitle>International journal of radiation biology</jtitle><addtitle>Int J Radiat Biol</addtitle><date>1993</date><risdate>1993</risdate><volume>63</volume><issue>3</issue><spage>331</spage><epage>337</epage><pages>331-337</pages><issn>0955-3002</issn><eissn>1362-3095</eissn><abstract>During the upgrading of the radiobiological facility at the Laboratori Nazionali di Legnaro (LNL) we found that uncorrected values of the proton energy were used in the past. This circumstance prompted us to perform the reevaluation of the physical parameters for all the proton beams used in our previous radiobiological investigations (Belli et al. 1987) and, subsequently, the re-evaluation of all our previous dose-response curves for inactivation and mutation induction (Belli et al. 1989, 1991). This re-evaluation leads to significant changes in the dose-response curves and in the RBE-LET relationships only at the two lowest energies (highest LET) used. These two points are not reliable for the identification of a peak in RBE-LET relationship for cell inactivation. In spite of that, the extent of the changes is not such as to modify the general conclusion previously drawn, pointing out that there is a LET range where protons are more effective than alpha-particles.</abstract><cop>London</cop><pub>Informa UK Ltd</pub><pmid>8095283</pmid><doi>10.1080/09553009314550441</doi><tpages>7</tpages></addata></record> |
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subjects | Animals Applied radiobiology (equipment, dosimetry...) Biological and medical sciences Biological effects of radiation Cell Line Cell Survival - radiation effects Cells, Cultured - radiation effects Cricetinae Dosage Compensation, Genetic Dose-Response Relationship, Radiation Energy Transfer Fundamental and applied biological sciences. Psychology Italy Laboratories Mutagenesis Protons Radiation Genetics Relative Biological Effectiveness Tissues, organs and organisms biophysics |
title | Inactivation and Mutation Induction in V79 Cells by Low Energy Protons: Re-evaluation of the Results at the LNL Facility |
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