Inactivation and Mutation Induction in V79 Cells by Low Energy Protons: Re-evaluation of the Results at the LNL Facility

During the upgrading of the radiobiological facility at the Laboratori Nazionali di Legnaro (LNL) we found that uncorrected values of the proton energy were used in the past. This circumstance prompted us to perform the reevaluation of the physical parameters for all the proton beams used in our pre...

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Veröffentlicht in:International journal of radiation biology 1993, Vol.63 (3), p.331-337
Hauptverfasser: Belli, M., Cera, F., Cherubini, R., Haque, A.M.I., Ianzini, F., Moschini, G., Sapora, O., Simone, G., Tabocchini, M.A., Tiveron, P.
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container_end_page 337
container_issue 3
container_start_page 331
container_title International journal of radiation biology
container_volume 63
creator Belli, M.
Cera, F.
Cherubini, R.
Haque, A.M.I.
Ianzini, F.
Moschini, G.
Sapora, O.
Simone, G.
Tabocchini, M.A.
Tiveron, P.
description During the upgrading of the radiobiological facility at the Laboratori Nazionali di Legnaro (LNL) we found that uncorrected values of the proton energy were used in the past. This circumstance prompted us to perform the reevaluation of the physical parameters for all the proton beams used in our previous radiobiological investigations (Belli et al. 1987) and, subsequently, the re-evaluation of all our previous dose-response curves for inactivation and mutation induction (Belli et al. 1989, 1991). This re-evaluation leads to significant changes in the dose-response curves and in the RBE-LET relationships only at the two lowest energies (highest LET) used. These two points are not reliable for the identification of a peak in RBE-LET relationship for cell inactivation. In spite of that, the extent of the changes is not such as to modify the general conclusion previously drawn, pointing out that there is a LET range where protons are more effective than alpha-particles.
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source MEDLINE; Taylor & Francis Medical Library - CRKN; Access via Taylor & Francis
subjects Animals
Applied radiobiology (equipment, dosimetry...)
Biological and medical sciences
Biological effects of radiation
Cell Line
Cell Survival - radiation effects
Cells, Cultured - radiation effects
Cricetinae
Dosage Compensation, Genetic
Dose-Response Relationship, Radiation
Energy Transfer
Fundamental and applied biological sciences. Psychology
Italy
Laboratories
Mutagenesis
Protons
Radiation Genetics
Relative Biological Effectiveness
Tissues, organs and organisms biophysics
title Inactivation and Mutation Induction in V79 Cells by Low Energy Protons: Re-evaluation of the Results at the LNL Facility
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