Time and dose-dependent activation of p53 serine 15 phosphorylation among cell lines with different radiation sensitivity

Purpose: Proper detection of DNA damage and signal transduction to other proteins following irradiation (IR) is essential for cellular integrity. The serine 15 (Ser15) on p53 is crucial for p53 stabilization and a requirement for transient and permanent cell cycle arrest. Here, we sought to determin...

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