Imperatorin alleviates ROS-mediated airway remodeling by targeting the Nrf2/HO-1 signaling pathway

In this study, we investigated the role and mechanism of imperatorin (IMP) in chronic inflammation and airway remodeling. The levels of TNF-α, IL-1β, IL-6, IL-8, VEGF, α-SMA, and ROS were detected by ELISA, immunohistochemistry (IHC), immunofluorescence, and Western blot. In addition, we evaluated t...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2020-05, Vol.84 (5), p.898-910
Hauptverfasser:	Xian, Zhemin, Choi, Yun Ho, Zheng, Mingyu, Jiang, Jingzhi, Zhao, Yuzhe, Wang, Chongyang, Li, Junfeng, Li, Yan, Li, Liangchang, Piao, Hongmei, Yan, Guanghai
Format:	Artikel
Sprache:	eng
Schlagworte:	airway remodeling Airway Remodeling - drug effects Animals Asthma - chemically induced Asthma - drug therapy Asthma - metabolism Cell Line Cytokines - metabolism Disease Models, Animal Female Furocoumarins - pharmacology Furocoumarins - therapeutic use Heme Oxygenase-1 - metabolism Imperatorin MAPK Membrane Proteins - metabolism Mice Mice, Inbred BALB C Myocytes, Smooth Muscle - metabolism NF-E2-Related Factor 2 - metabolism Ovalbumin - pharmacology PI3K/Akt Reactive Oxygen Species - metabolism ROS Signal Transduction - drug effects
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