5-aminolevulinic acid enhances cell death under thermal stress in certain cancer cell lines

5-aminolevulinic acid (5-ALA) is contained in all organisms and a starting substrate for heme biosynthesis. Since administration of 5-ALA specifically leads cancer cells to accumulate protoporphyrin IX (PpIX), a potent photosensitizer, we tested if 5-ALA also serves as a thermosensitizer. 5-ALA enha...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2015-03, Vol.79 (3), p.422-431
Hauptverfasser:	Chibazakura, Taku, Toriyabe, Yui, Fujii, Hiroshi, Takahashi, Kiwamu, Kawakami, Mariko, Kuwamura, Haruna, Haga, Hazuki, Ogura, Shun-ichiro, Abe, Fuminori, Nakajima, Motowo, Yoshikawa, Hirofumi, Tanaka, Tohru
Format:	Artikel
Sprache:	eng
Schlagworte:	5-aminolevulinic acid Aminolevulinic Acid - pharmacology ATP Binding Cassette Transporter, Subfamily G, Member 2 ATP-Binding Cassette Transporters - metabolism Biological Transport - drug effects cancer Cell Death - drug effects Cell Line, Tumor Ferrochelatase - metabolism Frataxin Gene Expression Regulation, Neoplastic - drug effects Heat-Shock Response - drug effects Humans Intracellular Space - drug effects Intracellular Space - metabolism Iron-Binding Proteins - metabolism Neoplasm Proteins - metabolism protoporphyrin IX Protoporphyrins - metabolism Reactive Oxygen Species - metabolism thermal stress
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