Alpha-mangostin promotes myoblast differentiation by modulating the gene-expression profile in C2C12 cells
Alpha-mangostin, a xanthone contained mostly in mangosteen pericarp, has been reported to exert various biological functions. However, little is known about involvement of this xanthone in the muscle differentiation process. Here, we report the effect of α-mangostin on murine skeletal muscle-derived...
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| Veröffentlicht in: | Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2014-11, Vol.78 (11), p.1923-1929 |
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| container_end_page | 1929 |
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| container_issue | 11 |
| container_start_page | 1923 |
| container_title | Bioscience, biotechnology, and biochemistry |
| container_volume | 78 |
| creator | Horiba, Taro Katsukawa, Masahiro Abe, Keiko Nakai, Yuji |
| description | Alpha-mangostin, a xanthone contained mostly in mangosteen pericarp, has been reported to exert various biological functions. However, little is known about involvement of this xanthone in the muscle differentiation process. Here, we report the effect of α-mangostin on murine skeletal muscle-derived C2C12 myoblasts. α-mangostin stimulated myoblast differentiation leading to myotube formation. DNA microarray analysis revealed that genes associated with myoblast differentiation and muscle cell component formation were up-regulated in α-mangostin-treated cells. These results indicate that α-mangostin promotes myoblast differentiation through modulating the gene-expression profile in myoblasts.
Alpha-mangostin promotes myoblast differentiation by stimulating expression of genes related to myotube formation. |
| doi_str_mv | 10.1080/09168451.2014.940832 |
| format | Article |
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Alpha-mangostin promotes myoblast differentiation by stimulating expression of genes related to myotube formation.</description><identifier>ISSN: 0916-8451</identifier><identifier>EISSN: 1347-6947</identifier><identifier>DOI: 10.1080/09168451.2014.940832</identifier><identifier>PMID: 25060354</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>alpha-mangostin ; Animals ; Cell Differentiation - drug effects ; Cell Line ; DNA microarray ; Gene Expression Regulation - drug effects ; Mice ; myoblast ; Myoblasts - cytology ; Myoblasts - drug effects ; myotube ; Oligonucleotide Array Sequence Analysis ; Protein Kinase Inhibitors - pharmacology ; Transcriptome ; xanthone ; Xanthones - pharmacology</subject><ispartof>Bioscience, biotechnology, and biochemistry, 2014-11, Vol.78 (11), p.1923-1929</ispartof><rights>2014 Japan Society for Bioscience, Biotechnology, and Agrochemistry 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c539t-61bd3927a3c5551c96d6cb7d370d1a8fb3f7605d161588132b0e85778ea2edb03</citedby><cites>FETCH-LOGICAL-c539t-61bd3927a3c5551c96d6cb7d370d1a8fb3f7605d161588132b0e85778ea2edb03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25060354$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Horiba, Taro</creatorcontrib><creatorcontrib>Katsukawa, Masahiro</creatorcontrib><creatorcontrib>Abe, Keiko</creatorcontrib><creatorcontrib>Nakai, Yuji</creatorcontrib><title>Alpha-mangostin promotes myoblast differentiation by modulating the gene-expression profile in C2C12 cells</title><title>Bioscience, biotechnology, and biochemistry</title><addtitle>Biosci Biotechnol Biochem</addtitle><description>Alpha-mangostin, a xanthone contained mostly in mangosteen pericarp, has been reported to exert various biological functions. However, little is known about involvement of this xanthone in the muscle differentiation process. Here, we report the effect of α-mangostin on murine skeletal muscle-derived C2C12 myoblasts. α-mangostin stimulated myoblast differentiation leading to myotube formation. DNA microarray analysis revealed that genes associated with myoblast differentiation and muscle cell component formation were up-regulated in α-mangostin-treated cells. These results indicate that α-mangostin promotes myoblast differentiation through modulating the gene-expression profile in myoblasts.
Alpha-mangostin promotes myoblast differentiation by stimulating expression of genes related to myotube formation.</description><subject>alpha-mangostin</subject><subject>Animals</subject><subject>Cell Differentiation - drug effects</subject><subject>Cell Line</subject><subject>DNA microarray</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Mice</subject><subject>myoblast</subject><subject>Myoblasts - cytology</subject><subject>Myoblasts - drug effects</subject><subject>myotube</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Protein Kinase Inhibitors - pharmacology</subject><subject>Transcriptome</subject><subject>xanthone</subject><subject>Xanthones - pharmacology</subject><issn>0916-8451</issn><issn>1347-6947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE2L1TAUhoMoznX0H4hk6aZ38tE06UqGi18w4EbXIW1O7mRIk5qk6P33tnTGpbgKJzzvcw4vQm8pOVKiyA3paadaQY-M0PbYt0Rx9gwdKG9l0_WtfI4OG9JszBV6VcoDIeuHoC_RFROkI1y0B_RwG-Z700wmnlOpPuI5pylVKHi6pCGYUrH1zkGGWL2pPkU8XPCU7BLWKZ5xvQd8hggN_J4zlLIRq8P5AHjVndiJMjxCCOU1euFMKPDm8b1GPz59_H760tx9-_z1dHvXjIL3tenoYHnPpOGjEIKOfWe7cZCWS2KpUW7gTnZEWNpRoRTlbCCghJQKDAM7EH6N3u_e9YyfC5SqJ1-2C0yEtBS9BpVikvQb2u7omFMpGZyes59MvmhK9NayfmpZby3rveU19u5xwzJMYP-GnmpdgZsdSMv8v8oPe8JHl_JkfqUcrK7mElJ22cTRF83_afgDY2mZnQ</recordid><startdate>20141102</startdate><enddate>20141102</enddate><creator>Horiba, Taro</creator><creator>Katsukawa, Masahiro</creator><creator>Abe, Keiko</creator><creator>Nakai, Yuji</creator><general>Taylor & Francis</general><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20141102</creationdate><title>Alpha-mangostin promotes myoblast differentiation by modulating the gene-expression profile in C2C12 cells</title><author>Horiba, Taro ; Katsukawa, Masahiro ; Abe, Keiko ; Nakai, Yuji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c539t-61bd3927a3c5551c96d6cb7d370d1a8fb3f7605d161588132b0e85778ea2edb03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>alpha-mangostin</topic><topic>Animals</topic><topic>Cell Differentiation - drug effects</topic><topic>Cell Line</topic><topic>DNA microarray</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Mice</topic><topic>myoblast</topic><topic>Myoblasts - cytology</topic><topic>Myoblasts - drug effects</topic><topic>myotube</topic><topic>Oligonucleotide Array Sequence Analysis</topic><topic>Protein Kinase Inhibitors - pharmacology</topic><topic>Transcriptome</topic><topic>xanthone</topic><topic>Xanthones - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Horiba, Taro</creatorcontrib><creatorcontrib>Katsukawa, Masahiro</creatorcontrib><creatorcontrib>Abe, Keiko</creatorcontrib><creatorcontrib>Nakai, Yuji</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bioscience, biotechnology, and biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Horiba, Taro</au><au>Katsukawa, Masahiro</au><au>Abe, Keiko</au><au>Nakai, Yuji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alpha-mangostin promotes myoblast differentiation by modulating the gene-expression profile in C2C12 cells</atitle><jtitle>Bioscience, biotechnology, and biochemistry</jtitle><addtitle>Biosci Biotechnol Biochem</addtitle><date>2014-11-02</date><risdate>2014</risdate><volume>78</volume><issue>11</issue><spage>1923</spage><epage>1929</epage><pages>1923-1929</pages><issn>0916-8451</issn><eissn>1347-6947</eissn><abstract>Alpha-mangostin, a xanthone contained mostly in mangosteen pericarp, has been reported to exert various biological functions. However, little is known about involvement of this xanthone in the muscle differentiation process. Here, we report the effect of α-mangostin on murine skeletal muscle-derived C2C12 myoblasts. α-mangostin stimulated myoblast differentiation leading to myotube formation. DNA microarray analysis revealed that genes associated with myoblast differentiation and muscle cell component formation were up-regulated in α-mangostin-treated cells. These results indicate that α-mangostin promotes myoblast differentiation through modulating the gene-expression profile in myoblasts.
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| identifier | ISSN: 0916-8451 |
| ispartof | Bioscience, biotechnology, and biochemistry, 2014-11, Vol.78 (11), p.1923-1929 |
| issn | 0916-8451 1347-6947 |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); Freely Accessible Japanese Titles; EZB-FREE-00999 freely available EZB journals |
| subjects | alpha-mangostin Animals Cell Differentiation - drug effects Cell Line DNA microarray Gene Expression Regulation - drug effects Mice myoblast Myoblasts - cytology Myoblasts - drug effects myotube Oligonucleotide Array Sequence Analysis Protein Kinase Inhibitors - pharmacology Transcriptome xanthone Xanthones - pharmacology |
| title | Alpha-mangostin promotes myoblast differentiation by modulating the gene-expression profile in C2C12 cells |
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