The multi-herbal formula Chong-Myung-Tang improves spatial memory and increases cell genesis in the dentate gyrus of aged mice
Chong-Myung-Tang (CMT) is a multi-herbal formula that has been used to improve memory. However, the potential mechanism remains unknown. The present study investigated the effects of CMT (50, 100, and 200 mg/kg) on spatial memory of aged mice. The behavioral training tests indicated that 200 mg/kg C...
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| Veröffentlicht in: | Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2014-10, Vol.78 (10), p.1710-1715 |
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| creator | Liu, Lei Zhang, Mingwei Zhang, Ruifen Lee, Mira Wang, Zhen Hou, Jingang Sung, Chang-Keun |
| description | Chong-Myung-Tang (CMT) is a multi-herbal formula that has been used to improve memory. However, the potential mechanism remains unknown. The present study investigated the effects of CMT (50, 100, and 200 mg/kg) on spatial memory of aged mice. The behavioral training tests indicated that 200 mg/kg CMT treatment can significantly improve spatial memory of aged mice in the Morris water maze. Moreover, cell survival was examined by injecting bromodeoxyuridine (BrdU) on the first three days. The result showed that 200 mg/kg CMT treatment significantly increased cell survival in the dentate gyrus. Cell proliferation was determined by injecting BrdU 2 h before the mice were killed. The result suggested that CMT treatments had no influence on cell proliferation in the dentate gyrus. Thus, an increase in cell survival in the dentate gyrus stimulated by CMT may be involved in the effect of CMT on spatial memory improvement.
The multi-herbal formula Chong-Myung-Tang increases cell survival but not cell proliferation in the dentate gyrus of aged mice. |
| doi_str_mv | 10.1080/09168451.2014.930319 |
| format | Article |
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The multi-herbal formula Chong-Myung-Tang increases cell survival but not cell proliferation in the dentate gyrus of aged mice.</description><identifier>ISSN: 0916-8451</identifier><identifier>EISSN: 1347-6947</identifier><identifier>DOI: 10.1080/09168451.2014.930319</identifier><identifier>PMID: 25273136</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Aging - physiology ; Animals ; Behavior, Animal - drug effects ; Behavior, Animal - physiology ; cell proliferation ; Cell Proliferation - drug effects ; cell survival ; Cell Survival - drug effects ; Chemistry, Pharmaceutical ; Chong-Myung-Tang ; dentate gyrus ; Dentate Gyrus - cytology ; Dentate Gyrus - drug effects ; Dentate Gyrus - physiology ; Male ; Maze Learning - drug effects ; Mice ; Mice, Inbred ICR ; Neurogenesis - drug effects ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; spatial memory ; Spatial Memory - drug effects</subject><ispartof>Bioscience, biotechnology, and biochemistry, 2014-10, Vol.78 (10), p.1710-1715</ispartof><rights>2014 Japan Society for Bioscience, Biotechnology, and Agrochemistry 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-e0488875b6338f4bc61c349686eb0d9e1d4392e1192a23017ffd3f903fc289653</citedby><cites>FETCH-LOGICAL-c427t-e0488875b6338f4bc61c349686eb0d9e1d4392e1192a23017ffd3f903fc289653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25273136$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Lei</creatorcontrib><creatorcontrib>Zhang, Mingwei</creatorcontrib><creatorcontrib>Zhang, Ruifen</creatorcontrib><creatorcontrib>Lee, Mira</creatorcontrib><creatorcontrib>Wang, Zhen</creatorcontrib><creatorcontrib>Hou, Jingang</creatorcontrib><creatorcontrib>Sung, Chang-Keun</creatorcontrib><title>The multi-herbal formula Chong-Myung-Tang improves spatial memory and increases cell genesis in the dentate gyrus of aged mice</title><title>Bioscience, biotechnology, and biochemistry</title><addtitle>Biosci Biotechnol Biochem</addtitle><description>Chong-Myung-Tang (CMT) is a multi-herbal formula that has been used to improve memory. However, the potential mechanism remains unknown. The present study investigated the effects of CMT (50, 100, and 200 mg/kg) on spatial memory of aged mice. The behavioral training tests indicated that 200 mg/kg CMT treatment can significantly improve spatial memory of aged mice in the Morris water maze. Moreover, cell survival was examined by injecting bromodeoxyuridine (BrdU) on the first three days. The result showed that 200 mg/kg CMT treatment significantly increased cell survival in the dentate gyrus. Cell proliferation was determined by injecting BrdU 2 h before the mice were killed. The result suggested that CMT treatments had no influence on cell proliferation in the dentate gyrus. Thus, an increase in cell survival in the dentate gyrus stimulated by CMT may be involved in the effect of CMT on spatial memory improvement.
The multi-herbal formula Chong-Myung-Tang increases cell survival but not cell proliferation in the dentate gyrus of aged mice.</description><subject>Aging - physiology</subject><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>Behavior, Animal - physiology</subject><subject>cell proliferation</subject><subject>Cell Proliferation - drug effects</subject><subject>cell survival</subject><subject>Cell Survival - drug effects</subject><subject>Chemistry, Pharmaceutical</subject><subject>Chong-Myung-Tang</subject><subject>dentate gyrus</subject><subject>Dentate Gyrus - cytology</subject><subject>Dentate Gyrus - drug effects</subject><subject>Dentate Gyrus - physiology</subject><subject>Male</subject><subject>Maze Learning - drug effects</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Neurogenesis - drug effects</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>spatial memory</subject><subject>Spatial Memory - drug effects</subject><issn>0916-8451</issn><issn>1347-6947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtv3CAUhVHVqJk8_kFVsezGE17GZlVVo_QhpepmskYYXzxUtpmC3cib_vZiOemy6gbEvd85cA8IvaVkT0lN7oiishYl3TNCxV5xwql6hXaUi6qQSlSv0W5FipW5RFcp_SAkF0r6Bl2yklWccrlDv48nwMPcT744QWxMj12I-Wzw4RTGrvi2zHk9mrHDfjjH8AsSTmcz-UwOMIS4YDO22I82gkm5aaHvcQcjJJ9yGU_Zv4VxMhPgbolzwsFh00GLB2_hBl040ye4fd6v0eOn--PhS_Hw_fPXw8eHwgpWTQUQUdd1VTaS89qJxkpquVCyltCQVgFtBVcMKFXMME5o5VzLnSLcWVYrWfJr9H7zzSP8nCFNevBpfaoZIcxJ07KWRCnGeEbFhtoYUorg9Dn6wcRFU6LX5PVL8npNXm_JZ9m75xvmZoD2r-gl6gzcbUCYz_9r-WFT-HH9FPMUYt_qySx9iC6a0fqk-T8d_gCQPqAN</recordid><startdate>20141003</startdate><enddate>20141003</enddate><creator>Liu, Lei</creator><creator>Zhang, Mingwei</creator><creator>Zhang, Ruifen</creator><creator>Lee, Mira</creator><creator>Wang, Zhen</creator><creator>Hou, Jingang</creator><creator>Sung, Chang-Keun</creator><general>Taylor & Francis</general><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20141003</creationdate><title>The multi-herbal formula Chong-Myung-Tang improves spatial memory and increases cell genesis in the dentate gyrus of aged mice</title><author>Liu, Lei ; Zhang, Mingwei ; Zhang, Ruifen ; Lee, Mira ; Wang, Zhen ; Hou, Jingang ; Sung, Chang-Keun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-e0488875b6338f4bc61c349686eb0d9e1d4392e1192a23017ffd3f903fc289653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aging - physiology</topic><topic>Animals</topic><topic>Behavior, Animal - drug effects</topic><topic>Behavior, Animal - physiology</topic><topic>cell proliferation</topic><topic>Cell Proliferation - drug effects</topic><topic>cell survival</topic><topic>Cell Survival - drug effects</topic><topic>Chemistry, Pharmaceutical</topic><topic>Chong-Myung-Tang</topic><topic>dentate gyrus</topic><topic>Dentate Gyrus - cytology</topic><topic>Dentate Gyrus - drug effects</topic><topic>Dentate Gyrus - physiology</topic><topic>Male</topic><topic>Maze Learning - drug effects</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Neurogenesis - drug effects</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>spatial memory</topic><topic>Spatial Memory - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Lei</creatorcontrib><creatorcontrib>Zhang, Mingwei</creatorcontrib><creatorcontrib>Zhang, Ruifen</creatorcontrib><creatorcontrib>Lee, Mira</creatorcontrib><creatorcontrib>Wang, Zhen</creatorcontrib><creatorcontrib>Hou, Jingang</creatorcontrib><creatorcontrib>Sung, Chang-Keun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bioscience, biotechnology, and biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Lei</au><au>Zhang, Mingwei</au><au>Zhang, Ruifen</au><au>Lee, Mira</au><au>Wang, Zhen</au><au>Hou, Jingang</au><au>Sung, Chang-Keun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The multi-herbal formula Chong-Myung-Tang improves spatial memory and increases cell genesis in the dentate gyrus of aged mice</atitle><jtitle>Bioscience, biotechnology, and biochemistry</jtitle><addtitle>Biosci Biotechnol Biochem</addtitle><date>2014-10-03</date><risdate>2014</risdate><volume>78</volume><issue>10</issue><spage>1710</spage><epage>1715</epage><pages>1710-1715</pages><issn>0916-8451</issn><eissn>1347-6947</eissn><abstract>Chong-Myung-Tang (CMT) is a multi-herbal formula that has been used to improve memory. However, the potential mechanism remains unknown. The present study investigated the effects of CMT (50, 100, and 200 mg/kg) on spatial memory of aged mice. The behavioral training tests indicated that 200 mg/kg CMT treatment can significantly improve spatial memory of aged mice in the Morris water maze. Moreover, cell survival was examined by injecting bromodeoxyuridine (BrdU) on the first three days. The result showed that 200 mg/kg CMT treatment significantly increased cell survival in the dentate gyrus. Cell proliferation was determined by injecting BrdU 2 h before the mice were killed. The result suggested that CMT treatments had no influence on cell proliferation in the dentate gyrus. Thus, an increase in cell survival in the dentate gyrus stimulated by CMT may be involved in the effect of CMT on spatial memory improvement.
The multi-herbal formula Chong-Myung-Tang increases cell survival but not cell proliferation in the dentate gyrus of aged mice.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>25273136</pmid><doi>10.1080/09168451.2014.930319</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); Freely Accessible Japanese Titles |
| subjects | Aging - physiology Animals Behavior, Animal - drug effects Behavior, Animal - physiology cell proliferation Cell Proliferation - drug effects cell survival Cell Survival - drug effects Chemistry, Pharmaceutical Chong-Myung-Tang dentate gyrus Dentate Gyrus - cytology Dentate Gyrus - drug effects Dentate Gyrus - physiology Male Maze Learning - drug effects Mice Mice, Inbred ICR Neurogenesis - drug effects Plant Extracts - chemistry Plant Extracts - pharmacology spatial memory Spatial Memory - drug effects |
| title | The multi-herbal formula Chong-Myung-Tang improves spatial memory and increases cell genesis in the dentate gyrus of aged mice |
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