The antifibrogenic effect of hepatocyte growth factor (HGF) on renal tubular (HK-2) cells is dependent on cell growth

Although several reports suggest an antifibrogenic effect of hepatocyte growth factor (HGF), an increased deposition of matrix induced by HGF has also been reported. These conflicting effects could result from a diverse proliferative state of the target cells. Aim of the present study was to evaluat...

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Veröffentlicht in:	Growth factors (Chur, Switzerland) Switzerland), 2009-01, Vol.27 (3), p.173-180
Hauptverfasser:	Esposito, Ciro, Parrilla, Bina, Cornacchia, Flavia, Grosjean, Fabrizio, Mangione, Filippo, Serpieri, Nicoletta, Valentino, Rossella, Villa, Luigi, Arra, Mariarosa, Esposito, Vittoria, Canton, Antonio Dal
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Differentiation - metabolism Cell Cycle - physiology Cell Proliferation Collagen Type IV - metabolism Extracellular Matrix - metabolism Fibrosis Fibrosis - metabolism growth factor Hepatocyte Growth Factor - pharmacology Hepatocyte Growth Factor - physiology Humans Kidney Tubules, Proximal - cytology Kidney Tubules, Proximal - drug effects Kidney Tubules, Proximal - metabolism Matrix Metalloproteinases - metabolism TGF-β
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