PULMONARY TOXICITY OF SIMULATED LUNAR AND MARTIAN DUSTS IN MICE: II. BIOMARKERS OF ACUTE RESPONSES AFTER INTRATRACHEAL INSTILLATION

Volcanic ashes from Arizona and Hawaii, with chemical and mineral properties similar to those of lunar and Martian soils, respectively, are used by the National Aeronautics and Space Administration (NASA) to simulate lunar and Martian environments for instrument tests. NASA needs toxicity data on th...

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Veröffentlicht in:	Inhalation toxicology 2002-09, Vol.14 (9), p.917-928
Hauptverfasser:	Lam, Chiu-Wing, James, John T., Latch, Judith N., Jr, Raymond F. Hamilton, Holian, Andrij
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Administration, Inhalation Aerospace Medicine Animals Apoptosis biomarkers Biomarkers - analysis Bronchoalveolar Lavage Fluid - chemistry Bronchoalveolar Lavage Fluid - cytology Cell Survival - drug effects Cosmic Dust - adverse effects Dose-Response Relationship, Drug Drug Synergism Intubation, Intratracheal Leukocyte Count Lung - chemistry Lung - drug effects Lung - pathology Lung Diseases - chemically induced Lung Diseases - pathology Macrophages, Alveolar - drug effects Macrophages, Alveolar - pathology Male Mice Mice, Inbred C57BL Neutrophils - drug effects Neutrophils - pathology Ozone - administration & dosage Ozone - adverse effects Proteins - analysis Silicon Dioxide - adverse effects simulated lunar dust simulated martian dust Time Factors Titanium - adverse effects
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