Olanzapine plasma level in relation to antimanic effect in the acute therapy of manic states
The aim of this study was to evaluate internal as well as external validity of the two most frequently used mania scales, the Young Mania Rating Scale (YMRS) and the Bech-Rafaelsen Mania Scale (MAS), in patients with DSM-IV mania. Mokken analysis was used to evaluate internal validity in which a coe...
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| Veröffentlicht in: | Nordic journal of psychiatry 2006, Vol.60 (2), p.181-182 |
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| container_title | Nordic journal of psychiatry |
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| creator | Bech, P. Gex-Fabry, M. Aubry, J.-M. Favre, S. Bertschy, G. |
| description | The aim of this study was to evaluate internal as well as external validity of the two most frequently used mania scales, the Young Mania Rating Scale (YMRS) and the Bech-Rafaelsen Mania Scale (MAS), in patients with DSM-IV mania. Mokken analysis was used to evaluate internal validity in which a coefficient of homogeneity of 0.40 or higher indicates that the total score is a sufficient statistic. The external validity was evaluated by plasma-level relationship of olanzapine. In total, 20 patients with DSM-IV mania were analysed, and the coefficient of homogeneity was acceptable for the MAS, but not for the YMRS. In a subgroup of females who over 2 weeks had received a fixed dose of 20 mg olanzapine daily, a significant association was found between MAS scores and plasma levels, but this association was not obtained with the YMRS. In conclusion, the MAS was found superior to the YMRS in regard to both internal and external validity. |
| doi_str_mv | 10.1080/08039480600601282 |
| format | Article |
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Mokken analysis was used to evaluate internal validity in which a coefficient of homogeneity of 0.40 or higher indicates that the total score is a sufficient statistic. The external validity was evaluated by plasma-level relationship of olanzapine. In total, 20 patients with DSM-IV mania were analysed, and the coefficient of homogeneity was acceptable for the MAS, but not for the YMRS. In a subgroup of females who over 2 weeks had received a fixed dose of 20 mg olanzapine daily, a significant association was found between MAS scores and plasma levels, but this association was not obtained with the YMRS. In conclusion, the MAS was found superior to the YMRS in regard to both internal and external validity.</description><identifier>ISSN: 0803-9488</identifier><identifier>EISSN: 1502-4725</identifier><identifier>DOI: 10.1080/08039480600601282</identifier><identifier>PMID: 16635940</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Antimanic Agents - blood ; Antimanic Agents - therapeutic use ; Antipsychotic Agents - blood ; Antipsychotic Agents - therapeutic use ; Benzodiazepines - blood ; Benzodiazepines - therapeutic use ; Bipolar Disorder - blood ; Bipolar Disorder - drug therapy ; Female ; Humans ; Male ; Mania rating scales ; Olanzapine ; Plasma concentration/effect ; Psychiatric Status Rating Scales ; Reproducibility of Results ; Sensitivity and Specificity</subject><ispartof>Nordic journal of psychiatry, 2006, Vol.60 (2), p.181-182</ispartof><rights>2006 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-5568f4d4ace0b9821d969999682c85d368aadbe1bdac5fe4cb572df12e57f29d3</citedby><cites>FETCH-LOGICAL-c427t-5568f4d4ace0b9821d969999682c85d368aadbe1bdac5fe4cb572df12e57f29d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/08039480600601282$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/08039480600601282$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>315,782,786,4028,27932,27933,27934,59656,59762,60445,60551,61230,61265,61411,61446</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16635940$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bech, P.</creatorcontrib><creatorcontrib>Gex-Fabry, M.</creatorcontrib><creatorcontrib>Aubry, J.-M.</creatorcontrib><creatorcontrib>Favre, S.</creatorcontrib><creatorcontrib>Bertschy, G.</creatorcontrib><title>Olanzapine plasma level in relation to antimanic effect in the acute therapy of manic states</title><title>Nordic journal of psychiatry</title><addtitle>Nord J Psychiatry</addtitle><description>The aim of this study was to evaluate internal as well as external validity of the two most frequently used mania scales, the Young Mania Rating Scale (YMRS) and the Bech-Rafaelsen Mania Scale (MAS), in patients with DSM-IV mania. Mokken analysis was used to evaluate internal validity in which a coefficient of homogeneity of 0.40 or higher indicates that the total score is a sufficient statistic. The external validity was evaluated by plasma-level relationship of olanzapine. In total, 20 patients with DSM-IV mania were analysed, and the coefficient of homogeneity was acceptable for the MAS, but not for the YMRS. In a subgroup of females who over 2 weeks had received a fixed dose of 20 mg olanzapine daily, a significant association was found between MAS scores and plasma levels, but this association was not obtained with the YMRS. In conclusion, the MAS was found superior to the YMRS in regard to both internal and external validity.</description><subject>Antimanic Agents - blood</subject><subject>Antimanic Agents - therapeutic use</subject><subject>Antipsychotic Agents - blood</subject><subject>Antipsychotic Agents - therapeutic use</subject><subject>Benzodiazepines - blood</subject><subject>Benzodiazepines - therapeutic use</subject><subject>Bipolar Disorder - blood</subject><subject>Bipolar Disorder - drug therapy</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Mania rating scales</subject><subject>Olanzapine</subject><subject>Plasma concentration/effect</subject><subject>Psychiatric Status Rating Scales</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><issn>0803-9488</issn><issn>1502-4725</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEuLFTEQhYMozp3RH-BGsnLXYx6dfqAbGXzBwGx0J4TqpMLtIZ20Sdrh-uvN5V4QESZUSEF955A6hLzi7Jqzgb2tV47twDpWi4tBPCE7rpho2l6op2R3nDcVGC7IZc73jDEpxficXPCuk2ps2Y78uPMQfsM6B6Srh7wA9fgLPZ0DTeihzDHQEimEMi8QZkPROTTlOC97pGC2gscuwXqg0dETlAsUzC_IMwc-48vze0W-f_r47eZLc3v3-evNh9vGtKIvjVLd4FrbgkE2jYPgduzGerpBmEFZ2Q0AdkI-WTDKYWsm1QvruEDVOzFaeUXenHzXFH9umIte5mzQ19Uwbll3_ci4lF0F-Qk0Keac0Ok11bXSQXOmj5Hq_yKtmtdn821a0P5VnDOswPsTMAcX0wIPMXmrCxx8TC5BMHPW8jH_d__I9wi-7A0k1PdxS6EG98jv_gCayZdL</recordid><startdate>2006</startdate><enddate>2006</enddate><creator>Bech, P.</creator><creator>Gex-Fabry, M.</creator><creator>Aubry, J.-M.</creator><creator>Favre, S.</creator><creator>Bertschy, G.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2006</creationdate><title>Olanzapine plasma level in relation to antimanic effect in the acute therapy of manic states</title><author>Bech, P. ; Gex-Fabry, M. ; Aubry, J.-M. ; Favre, S. ; Bertschy, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-5568f4d4ace0b9821d969999682c85d368aadbe1bdac5fe4cb572df12e57f29d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Antimanic Agents - blood</topic><topic>Antimanic Agents - therapeutic use</topic><topic>Antipsychotic Agents - blood</topic><topic>Antipsychotic Agents - therapeutic use</topic><topic>Benzodiazepines - blood</topic><topic>Benzodiazepines - therapeutic use</topic><topic>Bipolar Disorder - blood</topic><topic>Bipolar Disorder - drug therapy</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Mania rating scales</topic><topic>Olanzapine</topic><topic>Plasma concentration/effect</topic><topic>Psychiatric Status Rating Scales</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bech, P.</creatorcontrib><creatorcontrib>Gex-Fabry, M.</creatorcontrib><creatorcontrib>Aubry, J.-M.</creatorcontrib><creatorcontrib>Favre, S.</creatorcontrib><creatorcontrib>Bertschy, G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nordic journal of psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bech, P.</au><au>Gex-Fabry, M.</au><au>Aubry, J.-M.</au><au>Favre, S.</au><au>Bertschy, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Olanzapine plasma level in relation to antimanic effect in the acute therapy of manic states</atitle><jtitle>Nordic journal of psychiatry</jtitle><addtitle>Nord J Psychiatry</addtitle><date>2006</date><risdate>2006</risdate><volume>60</volume><issue>2</issue><spage>181</spage><epage>182</epage><pages>181-182</pages><issn>0803-9488</issn><eissn>1502-4725</eissn><abstract>The aim of this study was to evaluate internal as well as external validity of the two most frequently used mania scales, the Young Mania Rating Scale (YMRS) and the Bech-Rafaelsen Mania Scale (MAS), in patients with DSM-IV mania. Mokken analysis was used to evaluate internal validity in which a coefficient of homogeneity of 0.40 or higher indicates that the total score is a sufficient statistic. The external validity was evaluated by plasma-level relationship of olanzapine. In total, 20 patients with DSM-IV mania were analysed, and the coefficient of homogeneity was acceptable for the MAS, but not for the YMRS. In a subgroup of females who over 2 weeks had received a fixed dose of 20 mg olanzapine daily, a significant association was found between MAS scores and plasma levels, but this association was not obtained with the YMRS. In conclusion, the MAS was found superior to the YMRS in regard to both internal and external validity.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>16635940</pmid><doi>10.1080/08039480600601282</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Nordic journal of psychiatry, 2006, Vol.60 (2), p.181-182 |
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| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Antimanic Agents - blood Antimanic Agents - therapeutic use Antipsychotic Agents - blood Antipsychotic Agents - therapeutic use Benzodiazepines - blood Benzodiazepines - therapeutic use Bipolar Disorder - blood Bipolar Disorder - drug therapy Female Humans Male Mania rating scales Olanzapine Plasma concentration/effect Psychiatric Status Rating Scales Reproducibility of Results Sensitivity and Specificity |
| title | Olanzapine plasma level in relation to antimanic effect in the acute therapy of manic states |
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