Age-Related Effects on the Biological Clock and its Behavioral Output in a Primate
In humans, activity rhythms become fragmented and attenuated in the elderly. This suggests an alteration of the circadian system per se that could in turn affect the expression of biological rhythms. In primates, very few studies have analyzed the effect of aging on the circadian system. The mouse l...
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| Veröffentlicht in: | Chronobiology international 2006, Vol.23 (1-2), p.451-460 |
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| creator | Aujard, Fabienne Cayetanot, Florence Bentivoglio, Marina Perret, Martine |
| description | In humans, activity rhythms become fragmented and attenuated in the elderly. This suggests an alteration of the circadian system per se that could in turn affect the expression of biological rhythms. In primates, very few studies have analyzed the effect of aging on the circadian system. The mouse lemur provides a unique model of aging in non-human primates. To assess the effect of aging on the circadian system of this primate, we recorded the circadian and daily rhythms of locomotor activity of mouse lemurs of various ages. We also examined age-related changes in the daily rhythm of immunoreactivities for vasoactive intestinal polypeptide (VIP) and arginine-vasopressin (AVP) in suprachiasmatic nucleus neurons (SCN), two major peptides of the biological clock. Compared to adult animals, aged mouse lemurs showed a significant increase in daytime activity and an advanced activity onset. Moreover, when maintained in constant dim red light, aged animals exhibited a shortening of the free-running period compared to adult animals. In adults, AVP immunoreactivity (ir) peaked during the second part of the day, and VIP ir peaked during the night. In aged mouse lemurs, the peaks of AVP ir and VIP ir were significantly shifted with no change in amplitude. AVP ir was most intense at the beginning of the night; whereas, VIP ir peaked at the beginning of the daytime. A weakened oscillator could account for the rhythmic disorders often observed in the elderly. Changes in the daily rhythms of AVP ir and VIP ir may affect the ability of the SCN to transmit rhythmic information to other neural target sites, and thereby modify the expression of some biological rhythms. |
| doi_str_mv | 10.1080/07420520500482090 |
| format | Article |
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This suggests an alteration of the circadian system per se that could in turn affect the expression of biological rhythms. In primates, very few studies have analyzed the effect of aging on the circadian system. The mouse lemur provides a unique model of aging in non-human primates. To assess the effect of aging on the circadian system of this primate, we recorded the circadian and daily rhythms of locomotor activity of mouse lemurs of various ages. We also examined age-related changes in the daily rhythm of immunoreactivities for vasoactive intestinal polypeptide (VIP) and arginine-vasopressin (AVP) in suprachiasmatic nucleus neurons (SCN), two major peptides of the biological clock. Compared to adult animals, aged mouse lemurs showed a significant increase in daytime activity and an advanced activity onset. Moreover, when maintained in constant dim red light, aged animals exhibited a shortening of the free-running period compared to adult animals. In adults, AVP immunoreactivity (ir) peaked during the second part of the day, and VIP ir peaked during the night. In aged mouse lemurs, the peaks of AVP ir and VIP ir were significantly shifted with no change in amplitude. AVP ir was most intense at the beginning of the night; whereas, VIP ir peaked at the beginning of the daytime. A weakened oscillator could account for the rhythmic disorders often observed in the elderly. Changes in the daily rhythms of AVP ir and VIP ir may affect the ability of the SCN to transmit rhythmic information to other neural target sites, and thereby modify the expression of some biological rhythms.</description><identifier>ISSN: 0742-0528</identifier><identifier>EISSN: 1525-6073</identifier><identifier>DOI: 10.1080/07420520500482090</identifier><identifier>PMID: 16687318</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Aging ; Animal biology ; Animals ; Arginine - metabolism ; Behavior, Animal ; Biological Clocks ; Cheirogaleidae - anatomy & histology ; Circadian Rhythm ; Circadian Rhythm, Microcebus murinus ; Lemur ; Life Sciences ; Locomotor Activity ; Neuropeptides ; Neuropeptides - chemistry ; Peptides - chemistry ; Primates ; SCN ; Suprachiasmatic Nucleus - metabolism ; Time Factors ; Vasoactive Intestinal Peptide - metabolism ; Vasopressins - metabolism</subject><ispartof>Chronobiology international, 2006, Vol.23 (1-2), p.451-460</ispartof><rights>2006 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2006</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c469t-30fca7b09a45d0ca6d770c6f49dd5c0a2b4bc10cb7c489c97c7dd69fe3f93aed3</citedby><cites>FETCH-LOGICAL-c469t-30fca7b09a45d0ca6d770c6f49dd5c0a2b4bc10cb7c489c97c7dd69fe3f93aed3</cites><orcidid>0000-0003-1074-7784 ; 0000-0002-3801-0453</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/07420520500482090$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/07420520500482090$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>230,314,776,780,881,4010,27900,27901,27902,59620,60409,61194,61375</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16687318$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00086937$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Aujard, Fabienne</creatorcontrib><creatorcontrib>Cayetanot, Florence</creatorcontrib><creatorcontrib>Bentivoglio, Marina</creatorcontrib><creatorcontrib>Perret, Martine</creatorcontrib><title>Age-Related Effects on the Biological Clock and its Behavioral Output in a Primate</title><title>Chronobiology international</title><addtitle>Chronobiol Int</addtitle><description>In humans, activity rhythms become fragmented and attenuated in the elderly. This suggests an alteration of the circadian system per se that could in turn affect the expression of biological rhythms. In primates, very few studies have analyzed the effect of aging on the circadian system. The mouse lemur provides a unique model of aging in non-human primates. To assess the effect of aging on the circadian system of this primate, we recorded the circadian and daily rhythms of locomotor activity of mouse lemurs of various ages. We also examined age-related changes in the daily rhythm of immunoreactivities for vasoactive intestinal polypeptide (VIP) and arginine-vasopressin (AVP) in suprachiasmatic nucleus neurons (SCN), two major peptides of the biological clock. Compared to adult animals, aged mouse lemurs showed a significant increase in daytime activity and an advanced activity onset. Moreover, when maintained in constant dim red light, aged animals exhibited a shortening of the free-running period compared to adult animals. In adults, AVP immunoreactivity (ir) peaked during the second part of the day, and VIP ir peaked during the night. In aged mouse lemurs, the peaks of AVP ir and VIP ir were significantly shifted with no change in amplitude. AVP ir was most intense at the beginning of the night; whereas, VIP ir peaked at the beginning of the daytime. A weakened oscillator could account for the rhythmic disorders often observed in the elderly. Changes in the daily rhythms of AVP ir and VIP ir may affect the ability of the SCN to transmit rhythmic information to other neural target sites, and thereby modify the expression of some biological rhythms.</description><subject>Aging</subject><subject>Animal biology</subject><subject>Animals</subject><subject>Arginine - metabolism</subject><subject>Behavior, Animal</subject><subject>Biological Clocks</subject><subject>Cheirogaleidae - anatomy & histology</subject><subject>Circadian Rhythm</subject><subject>Circadian Rhythm, Microcebus murinus</subject><subject>Lemur</subject><subject>Life Sciences</subject><subject>Locomotor Activity</subject><subject>Neuropeptides</subject><subject>Neuropeptides - chemistry</subject><subject>Peptides - chemistry</subject><subject>Primates</subject><subject>SCN</subject><subject>Suprachiasmatic Nucleus - metabolism</subject><subject>Time Factors</subject><subject>Vasoactive Intestinal Peptide - metabolism</subject><subject>Vasopressins - metabolism</subject><issn>0742-0528</issn><issn>1525-6073</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV1rFDEYhYModq3-AG8kV4IXo282M8kEvdku_YKFlqLXIZOPTmp2siYzlf57M-yiSKGFQCDnOed9w0HoPYHPBFr4ArxeQlMOQN0uQcALtCDNsqkYcPoSLWa9KkB7hN7kfAdQTIy-RkeEsZZT0i7QzerWVjc2qNEafOqc1WPGccBjb_GJjyHeeq0CXoeof2I1GOyLfmJ7de9jKsLVNO6mEfsBK3yd_LbkvEWvnArZvjvcx-jH2en39UW1uTq_XK82la6ZGCsKTivegVB1Y0ArZjgHzVwtjGk0qGVXd5qA7riuW6EF19wYJpylTlBlDT1Gn_a5vQpyN89ODzIqLy9WGzm_zf9lgvJ7UtiPe3aX4q_J5lFufdY2BDXYOGXJuGhYA_WzIBGsZZyyApI9qFPMOVn3dwUCcm5HPmqneD4cwqdua80_x6GOAnzbA35wMW3V75iCkaN6CDG5pAbts6RP5X_9z95bFcZeq2TlXZzSUNp4Yrs_I7Kt5A</recordid><startdate>2006</startdate><enddate>2006</enddate><creator>Aujard, Fabienne</creator><creator>Cayetanot, Florence</creator><creator>Bentivoglio, Marina</creator><creator>Perret, Martine</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0003-1074-7784</orcidid><orcidid>https://orcid.org/0000-0002-3801-0453</orcidid></search><sort><creationdate>2006</creationdate><title>Age-Related Effects on the Biological Clock and its Behavioral Output in a Primate</title><author>Aujard, Fabienne ; Cayetanot, Florence ; Bentivoglio, Marina ; Perret, Martine</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c469t-30fca7b09a45d0ca6d770c6f49dd5c0a2b4bc10cb7c489c97c7dd69fe3f93aed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Aging</topic><topic>Animal biology</topic><topic>Animals</topic><topic>Arginine - metabolism</topic><topic>Behavior, Animal</topic><topic>Biological Clocks</topic><topic>Cheirogaleidae - anatomy & histology</topic><topic>Circadian Rhythm</topic><topic>Circadian Rhythm, Microcebus murinus</topic><topic>Lemur</topic><topic>Life Sciences</topic><topic>Locomotor Activity</topic><topic>Neuropeptides</topic><topic>Neuropeptides - chemistry</topic><topic>Peptides - chemistry</topic><topic>Primates</topic><topic>SCN</topic><topic>Suprachiasmatic Nucleus - metabolism</topic><topic>Time Factors</topic><topic>Vasoactive Intestinal Peptide - metabolism</topic><topic>Vasopressins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aujard, Fabienne</creatorcontrib><creatorcontrib>Cayetanot, Florence</creatorcontrib><creatorcontrib>Bentivoglio, Marina</creatorcontrib><creatorcontrib>Perret, Martine</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Chronobiology international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aujard, Fabienne</au><au>Cayetanot, Florence</au><au>Bentivoglio, Marina</au><au>Perret, Martine</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Age-Related Effects on the Biological Clock and its Behavioral Output in a Primate</atitle><jtitle>Chronobiology international</jtitle><addtitle>Chronobiol Int</addtitle><date>2006</date><risdate>2006</risdate><volume>23</volume><issue>1-2</issue><spage>451</spage><epage>460</epage><pages>451-460</pages><issn>0742-0528</issn><eissn>1525-6073</eissn><abstract>In humans, activity rhythms become fragmented and attenuated in the elderly. This suggests an alteration of the circadian system per se that could in turn affect the expression of biological rhythms. In primates, very few studies have analyzed the effect of aging on the circadian system. The mouse lemur provides a unique model of aging in non-human primates. To assess the effect of aging on the circadian system of this primate, we recorded the circadian and daily rhythms of locomotor activity of mouse lemurs of various ages. We also examined age-related changes in the daily rhythm of immunoreactivities for vasoactive intestinal polypeptide (VIP) and arginine-vasopressin (AVP) in suprachiasmatic nucleus neurons (SCN), two major peptides of the biological clock. Compared to adult animals, aged mouse lemurs showed a significant increase in daytime activity and an advanced activity onset. Moreover, when maintained in constant dim red light, aged animals exhibited a shortening of the free-running period compared to adult animals. In adults, AVP immunoreactivity (ir) peaked during the second part of the day, and VIP ir peaked during the night. In aged mouse lemurs, the peaks of AVP ir and VIP ir were significantly shifted with no change in amplitude. AVP ir was most intense at the beginning of the night; whereas, VIP ir peaked at the beginning of the daytime. A weakened oscillator could account for the rhythmic disorders often observed in the elderly. Changes in the daily rhythms of AVP ir and VIP ir may affect the ability of the SCN to transmit rhythmic information to other neural target sites, and thereby modify the expression of some biological rhythms.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>16687318</pmid><doi>10.1080/07420520500482090</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-1074-7784</orcidid><orcidid>https://orcid.org/0000-0002-3801-0453</orcidid></addata></record> |
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| subjects | Aging Animal biology Animals Arginine - metabolism Behavior, Animal Biological Clocks Cheirogaleidae - anatomy & histology Circadian Rhythm Circadian Rhythm, Microcebus murinus Lemur Life Sciences Locomotor Activity Neuropeptides Neuropeptides - chemistry Peptides - chemistry Primates SCN Suprachiasmatic Nucleus - metabolism Time Factors Vasoactive Intestinal Peptide - metabolism Vasopressins - metabolism |
| title | Age-Related Effects on the Biological Clock and its Behavioral Output in a Primate |
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