Substrate/Inhibitor Properties of Human Deoxycytidine Kinase (dCK) and Thymidine Kinases (Tk1 And Tk2) Towards the Sugar Moiety of Nucleosides, Including O′-Alkyl Analogues

Nucleoside analogues with modified sugar moieties have been examined for their substrate/inhibitor specificities towards highly purified deoxycytidine kinase (dCK) and thymidine kinases (tetrameric high-affinity form of TK1, and TK2) from human leukemic spleen. In particular, the analogues included...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nucleosides & nucleotides 1999-08, Vol.18 (8), p.1883-1903
Hauptverfasser:	Kierdaszuk, Borys, Krawiec, Krzysztof, Kazimierczuk, Zygmunt, Jacobsson, Ulla, Johansson, Nils G., Munch-petersen, Birgitte, Eriksson, Staffan, Shugar, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimetabolites, Antineoplastic - chemistry Antimetabolites, Antineoplastic - metabolism Antimetabolites, Antineoplastic - pharmacology Deoxycytidine Kinase - antagonists & inhibitors Deoxycytidine Kinase - metabolism Drug Design Enzyme Inhibitors - pharmacology Humans Leukemia - enzymology Methylation Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - metabolism Nucleosides - chemistry Nucleosides - metabolism Nucleosides - pharmacology Structure-Activity Relationship Substrate Specificity Thymidine Kinase - antagonists & inhibitors Thymidine Kinase - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!