Synthesis of 8-Substituted 7-(α-L-Arabinofuranosyl)theophyllines
Glycosylation of trimethysilyl theophylline by 1,2,3,5-tetra-O-acetyl-L-arabinofuranose yielding 7-(α-L-arabinofuranosyl)theophylline after deacetylation is reported. A method for the synthesis of 8-chlorotheophylline α-L-arabinofuranoside using N-chlorosuccinimide was found. Further nuc-leophilic d...
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| Veröffentlicht in: | Nucleosides & nucleotides 1993-06, Vol.12 (5), p.479-486 |
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| container_end_page | 486 |
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| container_issue | 5 |
| container_start_page | 479 |
| container_title | Nucleosides & nucleotides |
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| creator | Ozola, Vita Ramzaeva, Natalya Maurinsh, Yuris Lidaks, Margeris |
| description | Glycosylation of trimethysilyl theophylline by 1,2,3,5-tetra-O-acetyl-L-arabinofuranose yielding 7-(α-L-arabinofuranosyl)theophylline after deacetylation is reported. A method for the synthesis of 8-chlorotheophylline α-L-arabinofuranoside using N-chlorosuccinimide was found. Further nuc-leophilic displacement of chlorine has provided the corresponding 8-amino-and 8-methylaminotheophylline α-L-arabinofuranosides. |
| doi_str_mv | 10.1080/07328319308021217 |
| format | Article |
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A method for the synthesis of 8-chlorotheophylline α-L-arabinofuranoside using N-chlorosuccinimide was found. 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A method for the synthesis of 8-chlorotheophylline α-L-arabinofuranoside using N-chlorosuccinimide was found. 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| ispartof | Nucleosides & nucleotides, 1993-06, Vol.12 (5), p.479-486 |
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| source | Taylor & Francis |
| title | Synthesis of 8-Substituted 7-(α-L-Arabinofuranosyl)theophyllines |
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