Chemical and Biochemical Studies with Dithioate DNA

Chemical and Biochemical Studies with Dithioate DNA

Dithioate DNA was synthesized and used for various biochemical studies. Results from these studies indicate that dithioate DNA is a potent inhibitor of HIV Reverse Transcriptase, activates endogenous RNase H in Hela cell nuclear extracts, and is a useful probe for studying protein-DNA interactions.

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Veröffentlicht in:Nucleosides & nucleotides 1991-01, Vol.10 (1-3), p.47-59
Hauptverfasser: Caruthers, Marvin H., Beaton, Graham, Cummins, Lendell, Dellinger, Douglas, Graff, Darla, Ma, Yun-Xi, Marshall, William S., Sasmor, Henri, Shankland, Paula, Van Wu, John, Yau, Eric K.
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Sprache:eng
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Zusammenfassung:Dithioate DNA was synthesized and used for various biochemical studies. Results from these studies indicate that dithioate DNA is a potent inhibitor of HIV Reverse Transcriptase, activates endogenous RNase H in Hela cell nuclear extracts, and is a useful probe for studying protein-DNA interactions.
ISSN:0732-8311
2332-3892
DOI:10.1080/07328319108046435