New nanomicelle curcumin formulation for ocular delivery: improved stability, solubility, and ocular anti-inflammatory treatment

Context: A stable topical ophthalmic curcumin formulation with high solubility, stability, and efficacy is needed for pharmaceutical use in clinics. Objectives: The objective of this article was to describe a novel curcumin containing a nanomicelle formulation using a polyvinyl caprolactam-polyvinyl...

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Veröffentlicht in:	Drug development and industrial pharmacy 2017-11, Vol.43 (11), p.1846-1857
Hauptverfasser:	Li, Mengshuang, Xin, Meng, Guo, Chuanlong, Lin, Guiming, Wu, Xianggen
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Ophthalmic Animals Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - pharmacology Chemistry, Pharmaceutical Cornea - chemistry Cornea - physiopathology Curcumin Curcumin - chemistry Curcumin - pharmacology Drug Delivery Systems - methods Micelles nanomicelle Nanoparticles ocular drug delivery Ophthalmic Solutions - administration & dosage Ophthalmic Solutions - chemistry Polyethylene Glycols - chemistry polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer (PVCL-PVA-PEG) Polyvinyls - chemistry Rabbits Solubility stability
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