New nanomicelle curcumin formulation for ocular delivery: improved stability, solubility, and ocular anti-inflammatory treatment
Context: A stable topical ophthalmic curcumin formulation with high solubility, stability, and efficacy is needed for pharmaceutical use in clinics. Objectives: The objective of this article was to describe a novel curcumin containing a nanomicelle formulation using a polyvinyl caprolactam-polyvinyl...
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| Veröffentlicht in: | Drug development and industrial pharmacy 2017-11, Vol.43 (11), p.1846-1857 |
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| container_title | Drug development and industrial pharmacy |
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| creator | Li, Mengshuang Xin, Meng Guo, Chuanlong Lin, Guiming Wu, Xianggen |
| description | Context: A stable topical ophthalmic curcumin formulation with high solubility, stability, and efficacy is needed for pharmaceutical use in clinics.
Objectives: The objective of this article was to describe a novel curcumin containing a nanomicelle formulation using a polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol (PVCL-PVA-PEG) graft copolymer.
Methods: Nanomicelle curcumin was formulated and optimized and then further evaluated for in vitro cytotoxicity/in vivo ocular irritation, in vitro cellular uptake/in vivo corneal permeation, and in vitro antioxidant activity/in vivo anti-inflammatory efficacy.
Results: The solubility, chemical stability, and antioxidant activity were greatly improved after the encapsulation of the PVCL-PVA-PEG nanomicelles. The nanomicelle curcumin ophthalmic solution was simple to prepare and the nanomicelles are stable to the storage conditions, and it had good cellular tolerance. Nanomicelle curcumin also had excellent ocular tolerance in rabbits. The use of nanomicelles significantly improved in vitro cellular uptake and in vivo corneal permeation as well as improved anti-inflammatory efficacy when compared with a free curcumin solution.
Conclusions: These findings indicate that nanomicelles could be promising topical delivery systems for the ocular administration of curcumin. |
| doi_str_mv | 10.1080/03639045.2017.1349787 |
| format | Article |
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Objectives: The objective of this article was to describe a novel curcumin containing a nanomicelle formulation using a polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol (PVCL-PVA-PEG) graft copolymer.
Methods: Nanomicelle curcumin was formulated and optimized and then further evaluated for in vitro cytotoxicity/in vivo ocular irritation, in vitro cellular uptake/in vivo corneal permeation, and in vitro antioxidant activity/in vivo anti-inflammatory efficacy.
Results: The solubility, chemical stability, and antioxidant activity were greatly improved after the encapsulation of the PVCL-PVA-PEG nanomicelles. The nanomicelle curcumin ophthalmic solution was simple to prepare and the nanomicelles are stable to the storage conditions, and it had good cellular tolerance. Nanomicelle curcumin also had excellent ocular tolerance in rabbits. The use of nanomicelles significantly improved in vitro cellular uptake and in vivo corneal permeation as well as improved anti-inflammatory efficacy when compared with a free curcumin solution.
Conclusions: These findings indicate that nanomicelles could be promising topical delivery systems for the ocular administration of curcumin.</description><identifier>ISSN: 0363-9045</identifier><identifier>EISSN: 1520-5762</identifier><identifier>DOI: 10.1080/03639045.2017.1349787</identifier><identifier>PMID: 28665151</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Administration, Ophthalmic ; Animals ; Anti-Inflammatory Agents - chemistry ; Anti-Inflammatory Agents - pharmacology ; Chemistry, Pharmaceutical ; Cornea - chemistry ; Cornea - physiopathology ; Curcumin ; Curcumin - chemistry ; Curcumin - pharmacology ; Drug Delivery Systems - methods ; Micelles ; nanomicelle ; Nanoparticles ; ocular drug delivery ; Ophthalmic Solutions - administration & dosage ; Ophthalmic Solutions - chemistry ; Polyethylene Glycols - chemistry ; polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer (PVCL-PVA-PEG) ; Polyvinyls - chemistry ; Rabbits ; Solubility ; stability</subject><ispartof>Drug development and industrial pharmacy, 2017-11, Vol.43 (11), p.1846-1857</ispartof><rights>2017 Informa UK Limited, trading as Taylor & Francis Group 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c413t-274945c18899db1fb441a7a55f8f114b6a22262a7ef21587b4cb1bb9d0c02f2d3</citedby><cites>FETCH-LOGICAL-c413t-274945c18899db1fb441a7a55f8f114b6a22262a7ef21587b4cb1bb9d0c02f2d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28665151$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Mengshuang</creatorcontrib><creatorcontrib>Xin, Meng</creatorcontrib><creatorcontrib>Guo, Chuanlong</creatorcontrib><creatorcontrib>Lin, Guiming</creatorcontrib><creatorcontrib>Wu, Xianggen</creatorcontrib><title>New nanomicelle curcumin formulation for ocular delivery: improved stability, solubility, and ocular anti-inflammatory treatment</title><title>Drug development and industrial pharmacy</title><addtitle>Drug Dev Ind Pharm</addtitle><description>Context: A stable topical ophthalmic curcumin formulation with high solubility, stability, and efficacy is needed for pharmaceutical use in clinics.
Objectives: The objective of this article was to describe a novel curcumin containing a nanomicelle formulation using a polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol (PVCL-PVA-PEG) graft copolymer.
Methods: Nanomicelle curcumin was formulated and optimized and then further evaluated for in vitro cytotoxicity/in vivo ocular irritation, in vitro cellular uptake/in vivo corneal permeation, and in vitro antioxidant activity/in vivo anti-inflammatory efficacy.
Results: The solubility, chemical stability, and antioxidant activity were greatly improved after the encapsulation of the PVCL-PVA-PEG nanomicelles. The nanomicelle curcumin ophthalmic solution was simple to prepare and the nanomicelles are stable to the storage conditions, and it had good cellular tolerance. Nanomicelle curcumin also had excellent ocular tolerance in rabbits. The use of nanomicelles significantly improved in vitro cellular uptake and in vivo corneal permeation as well as improved anti-inflammatory efficacy when compared with a free curcumin solution.
Conclusions: These findings indicate that nanomicelles could be promising topical delivery systems for the ocular administration of curcumin.</description><subject>Administration, Ophthalmic</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents - chemistry</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Chemistry, Pharmaceutical</subject><subject>Cornea - chemistry</subject><subject>Cornea - physiopathology</subject><subject>Curcumin</subject><subject>Curcumin - chemistry</subject><subject>Curcumin - pharmacology</subject><subject>Drug Delivery Systems - methods</subject><subject>Micelles</subject><subject>nanomicelle</subject><subject>Nanoparticles</subject><subject>ocular drug delivery</subject><subject>Ophthalmic Solutions - administration & dosage</subject><subject>Ophthalmic Solutions - chemistry</subject><subject>Polyethylene Glycols - chemistry</subject><subject>polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer (PVCL-PVA-PEG)</subject><subject>Polyvinyls - chemistry</subject><subject>Rabbits</subject><subject>Solubility</subject><subject>stability</subject><issn>0363-9045</issn><issn>1520-5762</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM9O3DAQhy1UBAvlEVr5AZqtx7Hzp6dWK6CVULnQczR2bMmVHa8cB5Qbj07C7vbY08xI329G8xHyCdgWWMO-srIqWybkljOot1CKtm7qM7IByVkh64p_IJuVKVboklyN41_GgLdSXpBL3lSVBAkb8vrbvNABhxicNt4bqqekp-AGamMKk8fs4ntPo16mRHvj3bNJ8zfqwj7FZ9PTMaNy3uX5Cx2jn049Dv0phEN2hRusxxAwxzTTnAzmYIb8kZxb9KO5OdZr8ufu9mn3s3h4vP-1-_FQaAFlLngtWiE1NE3b9gqsEgKwRiltYwGEqpBzXnGsjeUgm1oJrUCptmeaccv78prIw16d4jgmY7t9cgHT3AHrVqPdyWi3Gu2ORpfc50NuP6lg-n-pk8IF-H4Alv8WZfgSk--7jLOPySYctBu78v833gAD-ojY</recordid><startdate>20171102</startdate><enddate>20171102</enddate><creator>Li, Mengshuang</creator><creator>Xin, Meng</creator><creator>Guo, Chuanlong</creator><creator>Lin, Guiming</creator><creator>Wu, Xianggen</creator><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20171102</creationdate><title>New nanomicelle curcumin formulation for ocular delivery: improved stability, solubility, and ocular anti-inflammatory treatment</title><author>Li, Mengshuang ; Xin, Meng ; Guo, Chuanlong ; Lin, Guiming ; Wu, Xianggen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413t-274945c18899db1fb441a7a55f8f114b6a22262a7ef21587b4cb1bb9d0c02f2d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Administration, Ophthalmic</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents - chemistry</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Chemistry, Pharmaceutical</topic><topic>Cornea - chemistry</topic><topic>Cornea - physiopathology</topic><topic>Curcumin</topic><topic>Curcumin - chemistry</topic><topic>Curcumin - pharmacology</topic><topic>Drug Delivery Systems - methods</topic><topic>Micelles</topic><topic>nanomicelle</topic><topic>Nanoparticles</topic><topic>ocular drug delivery</topic><topic>Ophthalmic Solutions - administration & dosage</topic><topic>Ophthalmic Solutions - chemistry</topic><topic>Polyethylene Glycols - chemistry</topic><topic>polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer (PVCL-PVA-PEG)</topic><topic>Polyvinyls - chemistry</topic><topic>Rabbits</topic><topic>Solubility</topic><topic>stability</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Mengshuang</creatorcontrib><creatorcontrib>Xin, Meng</creatorcontrib><creatorcontrib>Guo, Chuanlong</creatorcontrib><creatorcontrib>Lin, Guiming</creatorcontrib><creatorcontrib>Wu, Xianggen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Drug development and industrial pharmacy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Mengshuang</au><au>Xin, Meng</au><au>Guo, Chuanlong</au><au>Lin, Guiming</au><au>Wu, Xianggen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New nanomicelle curcumin formulation for ocular delivery: improved stability, solubility, and ocular anti-inflammatory treatment</atitle><jtitle>Drug development and industrial pharmacy</jtitle><addtitle>Drug Dev Ind Pharm</addtitle><date>2017-11-02</date><risdate>2017</risdate><volume>43</volume><issue>11</issue><spage>1846</spage><epage>1857</epage><pages>1846-1857</pages><issn>0363-9045</issn><eissn>1520-5762</eissn><abstract>Context: A stable topical ophthalmic curcumin formulation with high solubility, stability, and efficacy is needed for pharmaceutical use in clinics.
Objectives: The objective of this article was to describe a novel curcumin containing a nanomicelle formulation using a polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol (PVCL-PVA-PEG) graft copolymer.
Methods: Nanomicelle curcumin was formulated and optimized and then further evaluated for in vitro cytotoxicity/in vivo ocular irritation, in vitro cellular uptake/in vivo corneal permeation, and in vitro antioxidant activity/in vivo anti-inflammatory efficacy.
Results: The solubility, chemical stability, and antioxidant activity were greatly improved after the encapsulation of the PVCL-PVA-PEG nanomicelles. The nanomicelle curcumin ophthalmic solution was simple to prepare and the nanomicelles are stable to the storage conditions, and it had good cellular tolerance. Nanomicelle curcumin also had excellent ocular tolerance in rabbits. The use of nanomicelles significantly improved in vitro cellular uptake and in vivo corneal permeation as well as improved anti-inflammatory efficacy when compared with a free curcumin solution.
Conclusions: These findings indicate that nanomicelles could be promising topical delivery systems for the ocular administration of curcumin.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>28665151</pmid><doi>10.1080/03639045.2017.1349787</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; EBSCOhost Business Source Complete |
| subjects | Administration, Ophthalmic Animals Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - pharmacology Chemistry, Pharmaceutical Cornea - chemistry Cornea - physiopathology Curcumin Curcumin - chemistry Curcumin - pharmacology Drug Delivery Systems - methods Micelles nanomicelle Nanoparticles ocular drug delivery Ophthalmic Solutions - administration & dosage Ophthalmic Solutions - chemistry Polyethylene Glycols - chemistry polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer (PVCL-PVA-PEG) Polyvinyls - chemistry Rabbits Solubility stability |
| title | New nanomicelle curcumin formulation for ocular delivery: improved stability, solubility, and ocular anti-inflammatory treatment |
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