Evaluation of Tablet Formation of Different Lactoses by 3D Modeling and Fractal Analysis
ABSTRACT The aim of this study was to use 3D modeling to differentiate not only among the four different types of lactose α-lactose monohydrate, spray-dried lactose, agglomerated lactose and lactose anhydrous but also between products from different manufacturers. Further "box-counting" fr...
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| Veröffentlicht in: | Drug development and industrial pharmacy 2007-04, Vol.33 (4), p.353-372 |
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| creator | Jelcic, Z. Hauschild, K. Ogiermann, M. Picker-Freyer, K. M. |
| description | ABSTRACT
The aim of this study was to use 3D modeling to differentiate not only among the four different types of lactose α-lactose monohydrate, spray-dried lactose, agglomerated lactose and lactose anhydrous but also between products from different manufacturers. Further "box-counting" fractal analysis of SEM images was done to gain additional information on tableting characteristics and tablet properties which can be found in the fractal structure. Twelve different materials from different manufacturers were analyzed for their powder-technological and physicochemical properties. They were tableted on an eccentric tableting machine at graded maximum relative densities and the recorded data, namely force, time, and displacement were analyzed by the 3D modeling technique. Tablet properties such as, elastic recovery, crushing force and morphology were analyzed. The results show that 3D modeling can precisely distinguish deformation behavior for different types of lactose and also for the same type of material produced with a slightly different technique. Furthermore, the results showed that the amorphous content of the lactose determined the compactibility of the material, which is due to a reversible exceeding of the glass transition temperature of the material. The three fractal dimensions DBW (box surface dimension), DWBW (pore void box mass dimension), and DBBW (box solid mass dimension) are capable of describing morphological differences in lactose materials. Multivariate regression analysis showed that the fractal surface structure of the lactose-based materials is strongly correlated to tableting characteristics and tablet properties. Especially with regards to 3D modeling, it was found that the fractal indices can describe the parameters time plasticity d, pressure plasticity e, and fast elastic decompression, which is the inverse of ω. In addition, the 3D parameters are able to describe the powder and tablet fractal indices. In conclusion, the 3D modeling is not only able to characterize the compression process but it can also provide information on the final tablet morphology. |
| doi_str_mv | 10.1080/03639040701199241 |
| format | Article |
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The aim of this study was to use 3D modeling to differentiate not only among the four different types of lactose α-lactose monohydrate, spray-dried lactose, agglomerated lactose and lactose anhydrous but also between products from different manufacturers. Further "box-counting" fractal analysis of SEM images was done to gain additional information on tableting characteristics and tablet properties which can be found in the fractal structure. Twelve different materials from different manufacturers were analyzed for their powder-technological and physicochemical properties. They were tableted on an eccentric tableting machine at graded maximum relative densities and the recorded data, namely force, time, and displacement were analyzed by the 3D modeling technique. Tablet properties such as, elastic recovery, crushing force and morphology were analyzed. The results show that 3D modeling can precisely distinguish deformation behavior for different types of lactose and also for the same type of material produced with a slightly different technique. Furthermore, the results showed that the amorphous content of the lactose determined the compactibility of the material, which is due to a reversible exceeding of the glass transition temperature of the material. The three fractal dimensions DBW (box surface dimension), DWBW (pore void box mass dimension), and DBBW (box solid mass dimension) are capable of describing morphological differences in lactose materials. Multivariate regression analysis showed that the fractal surface structure of the lactose-based materials is strongly correlated to tableting characteristics and tablet properties. Especially with regards to 3D modeling, it was found that the fractal indices can describe the parameters time plasticity d, pressure plasticity e, and fast elastic decompression, which is the inverse of ω. In addition, the 3D parameters are able to describe the powder and tablet fractal indices. In conclusion, the 3D modeling is not only able to characterize the compression process but it can also provide information on the final tablet morphology.</description><identifier>ISSN: 0363-9045</identifier><identifier>EISSN: 1520-5762</identifier><identifier>DOI: 10.1080/03639040701199241</identifier><identifier>PMID: 17523001</identifier><language>eng</language><publisher>Colchester: Informa UK Ltd</publisher><subject>3D model ; agglomerated lactose ; Biological and medical sciences ; Chemistry, Pharmaceutical ; compression ; Crystallization ; Elasticity ; Excipients - chemistry ; fractal analysis ; Fractals ; General pharmacology ; Lactose - chemistry ; lactose anhydrous ; Medical sciences ; Microscopy, Electron, Scanning - methods ; Models, Structural ; Particle Size ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Phase Transition ; Regression Analysis ; Rheology ; spray-dried lactose ; Tablets - chemistry ; Technology, Pharmaceutical - methods ; Transition Temperature ; α-lactose monohydrate</subject><ispartof>Drug development and industrial pharmacy, 2007-04, Vol.33 (4), p.353-372</ispartof><rights>2007 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2007</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-f5241c0cb279321cc319fe428dafa19de5bed71acf56786355470b92d40d5b1e3</citedby><cites>FETCH-LOGICAL-c434t-f5241c0cb279321cc319fe428dafa19de5bed71acf56786355470b92d40d5b1e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/03639040701199241$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/03639040701199241$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,59647,59753,60436,60542,61221,61256,61402,61437</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18838759$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17523001$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jelcic, Z.</creatorcontrib><creatorcontrib>Hauschild, K.</creatorcontrib><creatorcontrib>Ogiermann, M.</creatorcontrib><creatorcontrib>Picker-Freyer, K. M.</creatorcontrib><title>Evaluation of Tablet Formation of Different Lactoses by 3D Modeling and Fractal Analysis</title><title>Drug development and industrial pharmacy</title><addtitle>Drug Dev Ind Pharm</addtitle><description>ABSTRACT
The aim of this study was to use 3D modeling to differentiate not only among the four different types of lactose α-lactose monohydrate, spray-dried lactose, agglomerated lactose and lactose anhydrous but also between products from different manufacturers. Further "box-counting" fractal analysis of SEM images was done to gain additional information on tableting characteristics and tablet properties which can be found in the fractal structure. Twelve different materials from different manufacturers were analyzed for their powder-technological and physicochemical properties. They were tableted on an eccentric tableting machine at graded maximum relative densities and the recorded data, namely force, time, and displacement were analyzed by the 3D modeling technique. Tablet properties such as, elastic recovery, crushing force and morphology were analyzed. The results show that 3D modeling can precisely distinguish deformation behavior for different types of lactose and also for the same type of material produced with a slightly different technique. Furthermore, the results showed that the amorphous content of the lactose determined the compactibility of the material, which is due to a reversible exceeding of the glass transition temperature of the material. The three fractal dimensions DBW (box surface dimension), DWBW (pore void box mass dimension), and DBBW (box solid mass dimension) are capable of describing morphological differences in lactose materials. Multivariate regression analysis showed that the fractal surface structure of the lactose-based materials is strongly correlated to tableting characteristics and tablet properties. Especially with regards to 3D modeling, it was found that the fractal indices can describe the parameters time plasticity d, pressure plasticity e, and fast elastic decompression, which is the inverse of ω. In addition, the 3D parameters are able to describe the powder and tablet fractal indices. In conclusion, the 3D modeling is not only able to characterize the compression process but it can also provide information on the final tablet morphology.</description><subject>3D model</subject><subject>agglomerated lactose</subject><subject>Biological and medical sciences</subject><subject>Chemistry, Pharmaceutical</subject><subject>compression</subject><subject>Crystallization</subject><subject>Elasticity</subject><subject>Excipients - chemistry</subject><subject>fractal analysis</subject><subject>Fractals</subject><subject>General pharmacology</subject><subject>Lactose - chemistry</subject><subject>lactose anhydrous</subject><subject>Medical sciences</subject><subject>Microscopy, Electron, Scanning - methods</subject><subject>Models, Structural</subject><subject>Particle Size</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Phase Transition</subject><subject>Regression Analysis</subject><subject>Rheology</subject><subject>spray-dried lactose</subject><subject>Tablets - chemistry</subject><subject>Technology, Pharmaceutical - methods</subject><subject>Transition Temperature</subject><subject>α-lactose monohydrate</subject><issn>0363-9045</issn><issn>1520-5762</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1PGzEQhi0EalLoD-BS-QK3bf2xjteCCwLSVgrikkq9rWbtcVnkrMHeBeXfd6MEEKrEybLneWfGDyHHnH3jrGLfmZxJw0qmGefGiJLvkSlXghVKz8Q-mW7qxQioCfmc8z1jXBilPpEJ10rI8Tolf66fIAzQt7Gj0dMlNAF7Oo9p9fp21XqPCbueLsD2MWOmzZrKK3oTHYa2-0uhc3SexiIEetFBWOc2H5EDDyHjl915SH7Pr5eXP4vF7Y9flxeLwpay7AuvxrUts43QRgpureTGYykqBx64cagadJqD9Wqmq5lUqtSsMcKVzKmGozwkp9u-Dyk-Dpj7etVmiyFAh3HItWZKKCHMCPItaFPMOaGvH1K7grSuOas3Ouv_dI6Zr7vmQ7NC95bY-RuBkx0A2ULwCTrb5jeuqmSl1Wb4-ZZrO79x-xxTcHUP6xDTS0h-tMfZu_gdQujvLCSs7-OQRuX5g1_8A0LCoQU</recordid><startdate>20070401</startdate><enddate>20070401</enddate><creator>Jelcic, Z.</creator><creator>Hauschild, K.</creator><creator>Ogiermann, M.</creator><creator>Picker-Freyer, K. M.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070401</creationdate><title>Evaluation of Tablet Formation of Different Lactoses by 3D Modeling and Fractal Analysis</title><author>Jelcic, Z. ; Hauschild, K. ; Ogiermann, M. ; Picker-Freyer, K. M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-f5241c0cb279321cc319fe428dafa19de5bed71acf56786355470b92d40d5b1e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>3D model</topic><topic>agglomerated lactose</topic><topic>Biological and medical sciences</topic><topic>Chemistry, Pharmaceutical</topic><topic>compression</topic><topic>Crystallization</topic><topic>Elasticity</topic><topic>Excipients - chemistry</topic><topic>fractal analysis</topic><topic>Fractals</topic><topic>General pharmacology</topic><topic>Lactose - chemistry</topic><topic>lactose anhydrous</topic><topic>Medical sciences</topic><topic>Microscopy, Electron, Scanning - methods</topic><topic>Models, Structural</topic><topic>Particle Size</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Phase Transition</topic><topic>Regression Analysis</topic><topic>Rheology</topic><topic>spray-dried lactose</topic><topic>Tablets - chemistry</topic><topic>Technology, Pharmaceutical - methods</topic><topic>Transition Temperature</topic><topic>α-lactose monohydrate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jelcic, Z.</creatorcontrib><creatorcontrib>Hauschild, K.</creatorcontrib><creatorcontrib>Ogiermann, M.</creatorcontrib><creatorcontrib>Picker-Freyer, K. M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Drug development and industrial pharmacy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jelcic, Z.</au><au>Hauschild, K.</au><au>Ogiermann, M.</au><au>Picker-Freyer, K. M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of Tablet Formation of Different Lactoses by 3D Modeling and Fractal Analysis</atitle><jtitle>Drug development and industrial pharmacy</jtitle><addtitle>Drug Dev Ind Pharm</addtitle><date>2007-04-01</date><risdate>2007</risdate><volume>33</volume><issue>4</issue><spage>353</spage><epage>372</epage><pages>353-372</pages><issn>0363-9045</issn><eissn>1520-5762</eissn><abstract>ABSTRACT
The aim of this study was to use 3D modeling to differentiate not only among the four different types of lactose α-lactose monohydrate, spray-dried lactose, agglomerated lactose and lactose anhydrous but also between products from different manufacturers. Further "box-counting" fractal analysis of SEM images was done to gain additional information on tableting characteristics and tablet properties which can be found in the fractal structure. Twelve different materials from different manufacturers were analyzed for their powder-technological and physicochemical properties. They were tableted on an eccentric tableting machine at graded maximum relative densities and the recorded data, namely force, time, and displacement were analyzed by the 3D modeling technique. Tablet properties such as, elastic recovery, crushing force and morphology were analyzed. The results show that 3D modeling can precisely distinguish deformation behavior for different types of lactose and also for the same type of material produced with a slightly different technique. Furthermore, the results showed that the amorphous content of the lactose determined the compactibility of the material, which is due to a reversible exceeding of the glass transition temperature of the material. The three fractal dimensions DBW (box surface dimension), DWBW (pore void box mass dimension), and DBBW (box solid mass dimension) are capable of describing morphological differences in lactose materials. Multivariate regression analysis showed that the fractal surface structure of the lactose-based materials is strongly correlated to tableting characteristics and tablet properties. Especially with regards to 3D modeling, it was found that the fractal indices can describe the parameters time plasticity d, pressure plasticity e, and fast elastic decompression, which is the inverse of ω. In addition, the 3D parameters are able to describe the powder and tablet fractal indices. In conclusion, the 3D modeling is not only able to characterize the compression process but it can also provide information on the final tablet morphology.</abstract><cop>Colchester</cop><pub>Informa UK Ltd</pub><pmid>17523001</pmid><doi>10.1080/03639040701199241</doi><tpages>20</tpages></addata></record> |
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| ispartof | Drug development and industrial pharmacy, 2007-04, Vol.33 (4), p.353-372 |
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| source | MEDLINE; Business Source Complete; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | 3D model agglomerated lactose Biological and medical sciences Chemistry, Pharmaceutical compression Crystallization Elasticity Excipients - chemistry fractal analysis Fractals General pharmacology Lactose - chemistry lactose anhydrous Medical sciences Microscopy, Electron, Scanning - methods Models, Structural Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Phase Transition Regression Analysis Rheology spray-dried lactose Tablets - chemistry Technology, Pharmaceutical - methods Transition Temperature α-lactose monohydrate |
| title | Evaluation of Tablet Formation of Different Lactoses by 3D Modeling and Fractal Analysis |
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