Supersaturation Produces High Bioavailability of Amorphous Danazol Particles Formed by Evaporative Precipitation into Aqueous Solution and Spray Freezing into Liquid Technologies

ABSTRACT The bioavailability of high surface area danazol formulations was evaluated in a mouse model to determine what effect high supersaturation, as measured in vitro, has on the absorption of a poorly water soluble drug. Danazol, a biopharmaceutics classification system II (BCS II) compound, was...

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Veröffentlicht in:	Drug development and industrial pharmacy 2006, Vol.32 (5), p.559-567
Hauptverfasser:	Vaughn, Jason M., McConville, Jason T., Crisp, Matthew T., Johnston, Keith P., Williams, Robert O.
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Animals Biological and medical sciences Biological Availability Chemical Phenomena Chemistry, Physical Chromatography, High Pressure Liquid Danazol - administration & dosage Danazol - chemistry Danazol - pharmacokinetics Drug Compounding Estrogen Antagonists - administration & dosage Estrogen Antagonists - chemistry Estrogen Antagonists - pharmacokinetics Excipients Freezing General pharmacology Male Medical sciences Mice Mice, Inbred ICR Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Powders Solutions
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