Dysphagia and dysmotility of the pharynx and oesophagus in patients with primary Sjögren's syndrome
Objectives: To assess the prevalence of pharyngeal and oesophageal symptoms and dysmotility in patients with primary Sjögren's syndrome (pSS) and relate these to autonomic nervous function. Methods: Twenty consecutive pSS patients, according to the American-European Consensus Criteria (AECC), a...
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| Veröffentlicht in: | Scandinavian journal of rheumatology 2007-01, Vol.36 (5), p.394-401 |
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| creator | Mandl, T. Ekberg, O. Wollmer, P. Manthorpe, R. Jacobsson, L. T. H. |
| description | Objectives: To assess the prevalence of pharyngeal and oesophageal symptoms and dysmotility in patients with primary Sjögren's syndrome (pSS) and relate these to autonomic nervous function.
Methods: Twenty consecutive pSS patients, according to the American-European Consensus Criteria (AECC), and 30 age- and sex-matched controls from the Swedish general population registry were studied. All subjects completed a pharyngeal and oesophageal symptoms questionnaire and were examined by pharyngeal and oesophageal video radiography. In addition, the pSS patients were examined by two different autonomic nervous function tests, the deep breathing test [calculating the expiration inspiration (E I) ratio] and the finger skin blood flow test [the vasoconstriction (VAC) index].
Results: pSS patients experienced significantly more dysphagia compared with controls (65% vs. 3%; p |
| doi_str_mv | 10.1080/03009740701607638 |
| format | Article |
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Methods: Twenty consecutive pSS patients, according to the American-European Consensus Criteria (AECC), and 30 age- and sex-matched controls from the Swedish general population registry were studied. All subjects completed a pharyngeal and oesophageal symptoms questionnaire and were examined by pharyngeal and oesophageal video radiography. In addition, the pSS patients were examined by two different autonomic nervous function tests, the deep breathing test [calculating the expiration inspiration (E I) ratio] and the finger skin blood flow test [the vasoconstriction (VAC) index].
Results: pSS patients experienced significantly more dysphagia compared with controls (65% vs. 3%; p<0.001). Pharyngeal (45% vs. 7%; p<0.01), oesophageal (80% vs. 7%; p<0.001) and gastro-oesophageal reflux symptoms (60% vs. 23%; p<0.01) were also more prevalent in pSS patients compared with controls while pharyngeal (15% vs. 17%; p = NS) and oesophageal dysmotility (40% vs. 30%; p = NS) were not. Dysphagia was not associated with dysmotility but was found to be associated with a decreased E I ratio [−1.05 (−1.51 to −0.40) in patients with dysphagia vs. −0.21 (−0.39 to 0.65) in patients without dysphagia; p<0.01].
Conclusion: Subjective swallowing difficulties were more common in pSS patients than in controls while objective signs of pharyngeal and oesophageal dysmotility were not. Dysphagia in pSS patients does not seem to be related to video radiographical signs of dysmotility but may be related to an impaired parasympathetic function.</description><identifier>ISSN: 0300-9742</identifier><identifier>ISSN: 1502-7732</identifier><identifier>EISSN: 1502-7732</identifier><identifier>DOI: 10.1080/03009740701607638</identifier><identifier>PMID: 17963171</identifier><identifier>CODEN: SJRHAT</identifier><language>eng</language><publisher>Colchester: Informa UK Ltd</publisher><subject>Adult ; Age of Onset ; Autonomic Nervous System - physiopathology ; Biological and medical sciences ; Clinical Medicine ; Deglutition Disorders - etiology ; Deglutition Disorders - physiopathology ; Esophageal Motility Disorders - etiology ; Esophageal Motility Disorders - physiopathology ; Esophagogastric Junction - physiopathology ; Esophagus ; Esophagus - physiopathology ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Klinisk medicin ; Male ; Medical and Health Sciences ; Medical sciences ; Medicin och hälsovetenskap ; Middle Aged ; Other diseases. Semiology ; Pharyngitis - etiology ; Pharyngitis - physiopathology ; Pharynx - physiopathology ; Reumatologi och inflammation ; Rheumatology and Autoimmunity ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; Sjogren's Syndrome - complications ; Sjogren's Syndrome - physiopathology</subject><ispartof>Scandinavian journal of rheumatology, 2007-01, Vol.36 (5), p.394-401</ispartof><rights>2007 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2007</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-410d1b913c1a3b4d2dee30150876ea34dbefa1bc84d6b22b9cffc903e11fa7d73</citedby><cites>FETCH-LOGICAL-c503t-410d1b913c1a3b4d2dee30150876ea34dbefa1bc84d6b22b9cffc903e11fa7d73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/03009740701607638$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/03009740701607638$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>230,314,777,781,882,27905,27906,59626,59732,60415,60521,61200,61235,61381,61416</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19194696$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17963171$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://lup.lub.lu.se/record/972390$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Mandl, T.</creatorcontrib><creatorcontrib>Ekberg, O.</creatorcontrib><creatorcontrib>Wollmer, P.</creatorcontrib><creatorcontrib>Manthorpe, R.</creatorcontrib><creatorcontrib>Jacobsson, L. T. H.</creatorcontrib><title>Dysphagia and dysmotility of the pharynx and oesophagus in patients with primary Sjögren's syndrome</title><title>Scandinavian journal of rheumatology</title><addtitle>Scand J Rheumatol</addtitle><description>Objectives: To assess the prevalence of pharyngeal and oesophageal symptoms and dysmotility in patients with primary Sjögren's syndrome (pSS) and relate these to autonomic nervous function.
Methods: Twenty consecutive pSS patients, according to the American-European Consensus Criteria (AECC), and 30 age- and sex-matched controls from the Swedish general population registry were studied. All subjects completed a pharyngeal and oesophageal symptoms questionnaire and were examined by pharyngeal and oesophageal video radiography. In addition, the pSS patients were examined by two different autonomic nervous function tests, the deep breathing test [calculating the expiration inspiration (E I) ratio] and the finger skin blood flow test [the vasoconstriction (VAC) index].
Results: pSS patients experienced significantly more dysphagia compared with controls (65% vs. 3%; p<0.001). Pharyngeal (45% vs. 7%; p<0.01), oesophageal (80% vs. 7%; p<0.001) and gastro-oesophageal reflux symptoms (60% vs. 23%; p<0.01) were also more prevalent in pSS patients compared with controls while pharyngeal (15% vs. 17%; p = NS) and oesophageal dysmotility (40% vs. 30%; p = NS) were not. Dysphagia was not associated with dysmotility but was found to be associated with a decreased E I ratio [−1.05 (−1.51 to −0.40) in patients with dysphagia vs. −0.21 (−0.39 to 0.65) in patients without dysphagia; p<0.01].
Conclusion: Subjective swallowing difficulties were more common in pSS patients than in controls while objective signs of pharyngeal and oesophageal dysmotility were not. Dysphagia in pSS patients does not seem to be related to video radiographical signs of dysmotility but may be related to an impaired parasympathetic function.</description><subject>Adult</subject><subject>Age of Onset</subject><subject>Autonomic Nervous System - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Clinical Medicine</subject><subject>Deglutition Disorders - etiology</subject><subject>Deglutition Disorders - physiopathology</subject><subject>Esophageal Motility Disorders - etiology</subject><subject>Esophageal Motility Disorders - physiopathology</subject><subject>Esophagogastric Junction - physiopathology</subject><subject>Esophagus</subject><subject>Esophagus - physiopathology</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Klinisk medicin</subject><subject>Male</subject><subject>Medical and Health Sciences</subject><subject>Medical sciences</subject><subject>Medicin och hälsovetenskap</subject><subject>Middle Aged</subject><subject>Other diseases. Semiology</subject><subject>Pharyngitis - etiology</subject><subject>Pharyngitis - physiopathology</subject><subject>Pharynx - physiopathology</subject><subject>Reumatologi och inflammation</subject><subject>Rheumatology and Autoimmunity</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><subject>Sjogren's Syndrome - complications</subject><subject>Sjogren's Syndrome - physiopathology</subject><issn>0300-9742</issn><issn>1502-7732</issn><issn>1502-7732</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2O1DAQhS0EYpqGA7BB3gCrhnLsjmMxGzT8Si2xANaWf6fdSuJgJ2pyMS7AxXDTgRFCmkWpFvW9V1V6CD0m8IJAAy-BAgjOgAOpgde0uYNWZAvVhnNa3UWr03xTgOoCPcj5AABMcHEfXRAuako4WSH7Zs7DXl0HhVVvsZ1zF8fQhnHG0eNx73CZprn__nscXY4neso49HhQY3D9mPExjHs8pNAVEn8-_PxxnVz_POM89zbFzj1E97xqs3u09DX6-u7tl6sPm92n9x-vXu82Zgt03DAClmhBqCGKamYr6xyF8lDDa6cos9p5RbRpmK11VWlhvDcCqCPEK245XaPd2Tcf3TBpuZwkowqynYZSupTMTjKiFK2Ml42vK8kaLaTWDUhfGW6Ber0tvmv07Gw3pPhtcnmUXcjGta3qXZyyrBvGQMBpLzmDJsWck_N_NxOQp6Tkf0kVzZPFfNKdszeKJZoCPF0AlY1qfVK9CfmGE0SwurBrdHnmQu9j6tQxptbKUc1tTH9E9LY7Xv0j3zvVjnujkpOHOKW-5HXLF78AjwrDAA</recordid><startdate>20070101</startdate><enddate>20070101</enddate><creator>Mandl, T.</creator><creator>Ekberg, O.</creator><creator>Wollmer, P.</creator><creator>Manthorpe, R.</creator><creator>Jacobsson, L. T. H.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D95</scope></search><sort><creationdate>20070101</creationdate><title>Dysphagia and dysmotility of the pharynx and oesophagus in patients with primary Sjögren's syndrome</title><author>Mandl, T. ; Ekberg, O. ; Wollmer, P. ; Manthorpe, R. ; Jacobsson, L. T. H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-410d1b913c1a3b4d2dee30150876ea34dbefa1bc84d6b22b9cffc903e11fa7d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Age of Onset</topic><topic>Autonomic Nervous System - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Clinical Medicine</topic><topic>Deglutition Disorders - etiology</topic><topic>Deglutition Disorders - physiopathology</topic><topic>Esophageal Motility Disorders - etiology</topic><topic>Esophageal Motility Disorders - physiopathology</topic><topic>Esophagogastric Junction - physiopathology</topic><topic>Esophagus</topic><topic>Esophagus - physiopathology</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Klinisk medicin</topic><topic>Male</topic><topic>Medical and Health Sciences</topic><topic>Medical sciences</topic><topic>Medicin och hälsovetenskap</topic><topic>Middle Aged</topic><topic>Other diseases. Semiology</topic><topic>Pharyngitis - etiology</topic><topic>Pharyngitis - physiopathology</topic><topic>Pharynx - physiopathology</topic><topic>Reumatologi och inflammation</topic><topic>Rheumatology and Autoimmunity</topic><topic>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><topic>Sjogren's Syndrome - complications</topic><topic>Sjogren's Syndrome - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mandl, T.</creatorcontrib><creatorcontrib>Ekberg, O.</creatorcontrib><creatorcontrib>Wollmer, P.</creatorcontrib><creatorcontrib>Manthorpe, R.</creatorcontrib><creatorcontrib>Jacobsson, L. T. H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Lunds universitet</collection><jtitle>Scandinavian journal of rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mandl, T.</au><au>Ekberg, O.</au><au>Wollmer, P.</au><au>Manthorpe, R.</au><au>Jacobsson, L. T. H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dysphagia and dysmotility of the pharynx and oesophagus in patients with primary Sjögren's syndrome</atitle><jtitle>Scandinavian journal of rheumatology</jtitle><addtitle>Scand J Rheumatol</addtitle><date>2007-01-01</date><risdate>2007</risdate><volume>36</volume><issue>5</issue><spage>394</spage><epage>401</epage><pages>394-401</pages><issn>0300-9742</issn><issn>1502-7732</issn><eissn>1502-7732</eissn><coden>SJRHAT</coden><abstract>Objectives: To assess the prevalence of pharyngeal and oesophageal symptoms and dysmotility in patients with primary Sjögren's syndrome (pSS) and relate these to autonomic nervous function.
Methods: Twenty consecutive pSS patients, according to the American-European Consensus Criteria (AECC), and 30 age- and sex-matched controls from the Swedish general population registry were studied. All subjects completed a pharyngeal and oesophageal symptoms questionnaire and were examined by pharyngeal and oesophageal video radiography. In addition, the pSS patients were examined by two different autonomic nervous function tests, the deep breathing test [calculating the expiration inspiration (E I) ratio] and the finger skin blood flow test [the vasoconstriction (VAC) index].
Results: pSS patients experienced significantly more dysphagia compared with controls (65% vs. 3%; p<0.001). Pharyngeal (45% vs. 7%; p<0.01), oesophageal (80% vs. 7%; p<0.001) and gastro-oesophageal reflux symptoms (60% vs. 23%; p<0.01) were also more prevalent in pSS patients compared with controls while pharyngeal (15% vs. 17%; p = NS) and oesophageal dysmotility (40% vs. 30%; p = NS) were not. Dysphagia was not associated with dysmotility but was found to be associated with a decreased E I ratio [−1.05 (−1.51 to −0.40) in patients with dysphagia vs. −0.21 (−0.39 to 0.65) in patients without dysphagia; p<0.01].
Conclusion: Subjective swallowing difficulties were more common in pSS patients than in controls while objective signs of pharyngeal and oesophageal dysmotility were not. Dysphagia in pSS patients does not seem to be related to video radiographical signs of dysmotility but may be related to an impaired parasympathetic function.</abstract><cop>Colchester</cop><pub>Informa UK Ltd</pub><pmid>17963171</pmid><doi>10.1080/03009740701607638</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0300-9742 |
| ispartof | Scandinavian journal of rheumatology, 2007-01, Vol.36 (5), p.394-401 |
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| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Adult Age of Onset Autonomic Nervous System - physiopathology Biological and medical sciences Clinical Medicine Deglutition Disorders - etiology Deglutition Disorders - physiopathology Esophageal Motility Disorders - etiology Esophageal Motility Disorders - physiopathology Esophagogastric Junction - physiopathology Esophagus Esophagus - physiopathology Female Gastroenterology. Liver. Pancreas. Abdomen Humans Klinisk medicin Male Medical and Health Sciences Medical sciences Medicin och hälsovetenskap Middle Aged Other diseases. Semiology Pharyngitis - etiology Pharyngitis - physiopathology Pharynx - physiopathology Reumatologi och inflammation Rheumatology and Autoimmunity Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Sjogren's Syndrome - complications Sjogren's Syndrome - physiopathology |
| title | Dysphagia and dysmotility of the pharynx and oesophagus in patients with primary Sjögren's syndrome |
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