Syndecan-1 expression is upregulated in degenerating articular cartilage in a transgenic mouse model for osteoarthritis

Objective: Mice heterozygous for the Del1 transgene locus with a short deletion mutation in the type II collagen gene develop early-onset degenerative changes in the knee joints that progress to end-stage osteoarthritis by the age of 12-15 months. This study focuses on the expression and distributio...

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