Glomerular filtration rate estimation using the Cockcroft-Gault and Modification of Diet in Renal Disease formulas for digoxin dose adjustment in patients with heart failure

Objective. The aim of this study was to compare the estimated glomerular filtration rate (GFR) using the Cockcroft-Gault and the 4-, 5-, and 6-variable Modification of Diet in Renal Disease (MDRD) formulas for digoxin dose adjustment. Methods. Steady-state serum digoxin concentrations were determine...

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Veröffentlicht in:	Upsala Journal of Medical Sciences 2009-01, Vol.114 (3), p.154-159
Hauptverfasser:	Vazquez-Hernandez, Marta, Bouzas, Lorena, Tutor, J.Carlos
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Cardiotonic Agents - administration & dosage Cardiotonic Agents - pharmacokinetics Cardiotonic Agents - therapeutic use Cockcroft-Gault Digoxin - administration & dosage Digoxin - pharmacokinetics Digoxin - therapeutic use digoxin total clearance Female Glomerular Filtration Rate Heart Failure - complications Heart Failure - drug therapy Humans Kidney Diseases - complications Kidney Diseases - diet therapy Kidney Diseases - physiopathology Male Middle Aged Modification of Diet in Renal Disease Original
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