Oxidative stress in non-small cell lung cancer: Role of nicotinamide adenine dinucleotide phosphate oxidase and glutathione

Background. Cigarette smoke is strongly associated with NSCLC, but the carcinogenesis of NSCLC is poorly understood. Methods. To discover the role of oxidative stress and anti-oxidative defense in NSCLC, we measured NADPH oxidase (NOX) activity, myeloperoxidase activity, 8-OHdG, and glutathione cont...

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Veröffentlicht in:	Acta oncologica 2009, Vol.48 (7), p.1054-1061
Hauptverfasser:	Ilonen, Ilkka K., Räsänen, Jari V., Sihvo, Eero I., Knuuttila, Aija, Salmenkivi, Kaisa M., Ahotupa, Markku O., Kinnula, Vuokko L., Salo, Jarmo A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - enzymology Adolescent Adult Aged Aged, 80 and over Antioxidants - metabolism Carcinoma, Non-Small-Cell Lung - enzymology Carcinoma, Squamous Cell - enzymology Case-Control Studies Deoxyguanosine - analogs & derivatives Deoxyguanosine - metabolism Female Glutathione - metabolism Humans Lung Neoplasms - enzymology Male Middle Aged NADPH Oxidases - metabolism Oxidative Stress Peroxidase - metabolism Smoking - adverse effects Young Adult
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