Neoadjuvant Chemotherapy with Cisplatin and Methotrexate in Patients with Muscle-Invasive Bladder Tumours

This prospective, randomized study based on two associated trials was designed to evaluate the effect of neoadjuvant chemotherapy with cisplatin and methotrexate with folinic acid rescue or no chemotherapy prior to local treatment in patients with T2-T4b, NX-3, MO transitional cell carcinoma of the...

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Veröffentlicht in:	Acta oncologica 2002, Vol.41 (5), p.447-456
Hauptverfasser:	Sengeløv, Lisa, Maase, Hans Von Der, Lundbeck, Finn, Barlebo, Henrik, Colstrup, Hans, Engelholm, Svend Aage, Krarup, Torben, Madsen, Ebbe Lindegård, Meyhoff, Hans Henrik, Mommsen, Søren, Nielsen, Ole Steen, Pedersen, Dorte, Steven, Kenneth, Sørensen, Bent
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Biomarkers - blood Carcinoma, Transitional Cell - drug therapy Carcinoma, Transitional Cell - mortality Carcinoma, Transitional Cell - pathology Carcinoma, Transitional Cell - radiotherapy Carcinoma, Transitional Cell - surgery Chemotherapy Chemotherapy, Adjuvant Cisplatin - administration & dosage Combined Modality Therapy Creatinine - blood Cystectomy Disease-Free Survival Female Humans Leucovorin - administration & dosage Life Tables Male Medical sciences Methotrexate - administration & dosage Middle Aged Muscle, Smooth - pathology Neoadjuvant Therapy Neoplasm Invasiveness Pharmacology. Drug treatments Prospective Studies Radiotherapy, High-Energy Survival Analysis Survival Rate Treatment Outcome Urinary Bladder Neoplasms - drug therapy Urinary Bladder Neoplasms - mortality Urinary Bladder Neoplasms - pathology Urinary Bladder Neoplasms - radiotherapy Urinary Bladder Neoplasms - surgery
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