Inhibitory Effect on LPS-Induced Retinal Microglial Activation of Downregulation of t-PA Expression by siRNA Interference

Purpose: This study investigated the expression and release of tissue plasminogen activator (t-PA) in lipopolysaccharide (LPS)-induced retinal microglia activation. We evaluated change in microglia activation following down-regulation of t-PA expression by siRNA interference. Methods: The primary cu...

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Veröffentlicht in:	Current eye research 2009-01, Vol.34 (6), p.476-484
Hauptverfasser:	Wang, Wen-Ying, Xu, Ge-Zhi, Tian, Jie, Sprecher, Alicia J.
Format:	Artikel
Sprache:	eng
Schlagworte:	activation Animals Animals, Newborn Blotting, Western cell culture Cells, Cultured Cytokines - metabolism Enzyme-Linked Immunosorbent Assay Fluorescent Antibody Technique, Indirect Gene Expression Regulation - drug effects Lipopolysaccharides - pharmacology microglia Microglia - drug effects Microglia - metabolism Rats Rats, Sprague-Dawley retina Retinal Neurons - drug effects Retinal Neurons - metabolism RNA Interference - physiology RNA, Messenger - metabolism RNA, Small Interfering - pharmacology tissue plasminogen activator Tissue Plasminogen Activator - antagonists & inhibitors Tissue Plasminogen Activator - genetics Tissue Plasminogen Activator - metabolism Transfection
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