Development and Evaluation of the Specificity of a Cathepsin D Proximal Promoter in the Eye

Purpose: Recombinant adeno-associated virus (rAAV)-mediated gene delivery has emerged as a valuable tool for alternative treatment of ocular diseases. Cellular specificity of transgene expression could be influenced by either the viral capsid or the choice of promoter. The use of cellular promoter,...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Current eye research 2005, Vol.30 (1), p.53-61
Hauptverfasser:	Sutanto, Erika N., Zhang, Dan, Lai, Yvonne K. Y., Shen, Wei-Yong, Rakoczy, Elizabeth P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cathepsin D - genetics cathepsin D gene promoter Cell Culture Techniques Cytomegalovirus - genetics Dependovirus - genetics Flow Cytometry Gene Expression - physiology Genetic Therapy Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Humans Microscopy, Fluorescence Middle Aged Pigment Epithelium of Eye - metabolism Plasmids Promoter Regions, Genetic Rats Rats, Mutant Strains recombinant adeno-associated virus Retina - metabolism retinal pigment epithelium Retinitis Pigmentosa - metabolism Sensitivity and Specificity Transduction, Genetic Transfection
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!