Cerebral response to speech in vegetative and minimally conscious states after traumatic brain injury
Primary objective: To study cerebral response in a functional magnetic resonance imaging (fMRI) task of speech perception in a sample of patients in vegetative state (VS) and minimally conscious state (MCS) after traumatic brain injury. Methods: Three patients in VS, four patients in MCS and 19 heal...
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| Veröffentlicht in: | Brain injury 2008-01, Vol.22 (11), p.882-890 |
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| creator | Fernández-Espejo, Davinia Junqué, Carme Vendrell, Pere Bernabeu, Montserrat Roig, Teresa Bargalló, Nuria Mercader, José María |
| description | Primary objective: To study cerebral response in a functional magnetic resonance imaging (fMRI) task of speech perception in a sample of patients in vegetative state (VS) and minimally conscious state (MCS) after traumatic brain injury.
Methods: Three patients in VS, four patients in MCS and 19 healthy volunteers were enrolled for the study. All subjects underwent an fMRI task of passive listening of narratives played forward and backward, alternated with periods of silence. This study analysed cerebral response to language and to complex sound processing in the healthy subjects' group and in each patient, using SPM5.
Results: One patient in VS and one in MCS showed cerebral responses to language and to complex sound very similar to those shown by the healthy volunteers. Two more patients, one in VS and one in MCS, showed significant responses to complex sound only. Finally, one patient in VS and one patient in MCS failed to show significant activation in response to either stimulus.
Conclusions: Some patients in VS and MCS can preserve cerebral responses to language and auditory stimuli. fMRI may be useful to identify these responses, which may pass unnoticed in a bedside examination. |
| doi_str_mv | 10.1080/02699050802403573 |
| format | Article |
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Methods: Three patients in VS, four patients in MCS and 19 healthy volunteers were enrolled for the study. All subjects underwent an fMRI task of passive listening of narratives played forward and backward, alternated with periods of silence. This study analysed cerebral response to language and to complex sound processing in the healthy subjects' group and in each patient, using SPM5.
Results: One patient in VS and one in MCS showed cerebral responses to language and to complex sound very similar to those shown by the healthy volunteers. Two more patients, one in VS and one in MCS, showed significant responses to complex sound only. Finally, one patient in VS and one patient in MCS failed to show significant activation in response to either stimulus.
Conclusions: Some patients in VS and MCS can preserve cerebral responses to language and auditory stimuli. fMRI may be useful to identify these responses, which may pass unnoticed in a bedside examination.</description><identifier>ISSN: 0269-9052</identifier><identifier>EISSN: 1362-301X</identifier><identifier>DOI: 10.1080/02699050802403573</identifier><identifier>PMID: 18850346</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Acoustic Stimulation - methods ; Adolescent ; Adult ; Auditory Perception - physiology ; Awareness ; Brain Injuries - complications ; Brain Injuries - psychology ; Consciousness - physiology ; Female ; Functional magnetic resonance imaging ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; minimally conscious state ; Persistent Vegetative State - diagnosis ; Persistent Vegetative State - physiopathology ; Speech Perception - physiology ; traumatic brain injury ; vegetative state</subject><ispartof>Brain injury, 2008-01, Vol.22 (11), p.882-890</ispartof><rights>2008 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c404t-4612927af588b916f71e107fe24f4c0a5ea5049f6497a9b233918409219947283</citedby><cites>FETCH-LOGICAL-c404t-4612927af588b916f71e107fe24f4c0a5ea5049f6497a9b233918409219947283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/02699050802403573$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/02699050802403573$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,59626,59732,60415,60521,61200,61235,61381,61416</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18850346$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fernández-Espejo, Davinia</creatorcontrib><creatorcontrib>Junqué, Carme</creatorcontrib><creatorcontrib>Vendrell, Pere</creatorcontrib><creatorcontrib>Bernabeu, Montserrat</creatorcontrib><creatorcontrib>Roig, Teresa</creatorcontrib><creatorcontrib>Bargalló, Nuria</creatorcontrib><creatorcontrib>Mercader, José María</creatorcontrib><title>Cerebral response to speech in vegetative and minimally conscious states after traumatic brain injury</title><title>Brain injury</title><addtitle>Brain Inj</addtitle><description>Primary objective: To study cerebral response in a functional magnetic resonance imaging (fMRI) task of speech perception in a sample of patients in vegetative state (VS) and minimally conscious state (MCS) after traumatic brain injury.
Methods: Three patients in VS, four patients in MCS and 19 healthy volunteers were enrolled for the study. All subjects underwent an fMRI task of passive listening of narratives played forward and backward, alternated with periods of silence. This study analysed cerebral response to language and to complex sound processing in the healthy subjects' group and in each patient, using SPM5.
Results: One patient in VS and one in MCS showed cerebral responses to language and to complex sound very similar to those shown by the healthy volunteers. Two more patients, one in VS and one in MCS, showed significant responses to complex sound only. Finally, one patient in VS and one patient in MCS failed to show significant activation in response to either stimulus.
Conclusions: Some patients in VS and MCS can preserve cerebral responses to language and auditory stimuli. fMRI may be useful to identify these responses, which may pass unnoticed in a bedside examination.</description><subject>Acoustic Stimulation - methods</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Auditory Perception - physiology</subject><subject>Awareness</subject><subject>Brain Injuries - complications</subject><subject>Brain Injuries - psychology</subject><subject>Consciousness - physiology</subject><subject>Female</subject><subject>Functional magnetic resonance imaging</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>minimally conscious state</subject><subject>Persistent Vegetative State - diagnosis</subject><subject>Persistent Vegetative State - physiopathology</subject><subject>Speech Perception - physiology</subject><subject>traumatic brain injury</subject><subject>vegetative state</subject><issn>0269-9052</issn><issn>1362-301X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1rVDEUxYNY7Fj9A9xIVu6e5vu9oBsZ_IKCmxa6C5nMjZMhLxmTvJb5702ZARGhq3vh_s7h3IPQG0reUzKRD4QprYnsKxOEy5E_QyvKFRs4oXfP0erxPnSAXaKXte4JIVRS8gJd0mmShAu1QrCGAptiIy5QDzlVwC3jegBwOxwSvodf0GwL94Bt2uI5pDDbGI_YddaFvFRc-x0qtr5Bwa3YZe68w92060PaL-X4Cl14Gyu8Ps8rdPv1y836-3D989uP9efrwQki2iAUZZqN1stp2miq_EiBktEDE144YiVYSYT2SujR6g3jXNNJEM2o1mJkE79C706-h5J_L1CbmUN1EKNN0KMapZWkUskO0hPoSq61gDeH0h8rR0OJeezW_Ndt17w9my-bGbZ_FecyO_DpBITkc5ntQy5xa5o9xlx8scmFavhT_h__ke_AxrZztoDZ56WkXtwT6f4ARLKZhw</recordid><startdate>20080101</startdate><enddate>20080101</enddate><creator>Fernández-Espejo, Davinia</creator><creator>Junqué, Carme</creator><creator>Vendrell, Pere</creator><creator>Bernabeu, Montserrat</creator><creator>Roig, Teresa</creator><creator>Bargalló, Nuria</creator><creator>Mercader, José María</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080101</creationdate><title>Cerebral response to speech in vegetative and minimally conscious states after traumatic brain injury</title><author>Fernández-Espejo, Davinia ; Junqué, Carme ; Vendrell, Pere ; Bernabeu, Montserrat ; Roig, Teresa ; Bargalló, Nuria ; Mercader, José María</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c404t-4612927af588b916f71e107fe24f4c0a5ea5049f6497a9b233918409219947283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Acoustic Stimulation - methods</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Auditory Perception - physiology</topic><topic>Awareness</topic><topic>Brain Injuries - complications</topic><topic>Brain Injuries - psychology</topic><topic>Consciousness - physiology</topic><topic>Female</topic><topic>Functional magnetic resonance imaging</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>minimally conscious state</topic><topic>Persistent Vegetative State - diagnosis</topic><topic>Persistent Vegetative State - physiopathology</topic><topic>Speech Perception - physiology</topic><topic>traumatic brain injury</topic><topic>vegetative state</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fernández-Espejo, Davinia</creatorcontrib><creatorcontrib>Junqué, Carme</creatorcontrib><creatorcontrib>Vendrell, Pere</creatorcontrib><creatorcontrib>Bernabeu, Montserrat</creatorcontrib><creatorcontrib>Roig, Teresa</creatorcontrib><creatorcontrib>Bargalló, Nuria</creatorcontrib><creatorcontrib>Mercader, José María</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Brain injury</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fernández-Espejo, Davinia</au><au>Junqué, Carme</au><au>Vendrell, Pere</au><au>Bernabeu, Montserrat</au><au>Roig, Teresa</au><au>Bargalló, Nuria</au><au>Mercader, José María</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cerebral response to speech in vegetative and minimally conscious states after traumatic brain injury</atitle><jtitle>Brain injury</jtitle><addtitle>Brain Inj</addtitle><date>2008-01-01</date><risdate>2008</risdate><volume>22</volume><issue>11</issue><spage>882</spage><epage>890</epage><pages>882-890</pages><issn>0269-9052</issn><eissn>1362-301X</eissn><abstract>Primary objective: To study cerebral response in a functional magnetic resonance imaging (fMRI) task of speech perception in a sample of patients in vegetative state (VS) and minimally conscious state (MCS) after traumatic brain injury.
Methods: Three patients in VS, four patients in MCS and 19 healthy volunteers were enrolled for the study. All subjects underwent an fMRI task of passive listening of narratives played forward and backward, alternated with periods of silence. This study analysed cerebral response to language and to complex sound processing in the healthy subjects' group and in each patient, using SPM5.
Results: One patient in VS and one in MCS showed cerebral responses to language and to complex sound very similar to those shown by the healthy volunteers. Two more patients, one in VS and one in MCS, showed significant responses to complex sound only. Finally, one patient in VS and one patient in MCS failed to show significant activation in response to either stimulus.
Conclusions: Some patients in VS and MCS can preserve cerebral responses to language and auditory stimuli. fMRI may be useful to identify these responses, which may pass unnoticed in a bedside examination.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>18850346</pmid><doi>10.1080/02699050802403573</doi><tpages>9</tpages></addata></record> |
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| source | MEDLINE; Taylor & Francis:Master (3349 titles); Taylor & Francis Medical Library - CRKN |
| subjects | Acoustic Stimulation - methods Adolescent Adult Auditory Perception - physiology Awareness Brain Injuries - complications Brain Injuries - psychology Consciousness - physiology Female Functional magnetic resonance imaging Humans Magnetic Resonance Imaging Male Middle Aged minimally conscious state Persistent Vegetative State - diagnosis Persistent Vegetative State - physiopathology Speech Perception - physiology traumatic brain injury vegetative state |
| title | Cerebral response to speech in vegetative and minimally conscious states after traumatic brain injury |
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