Preoperative prognostic value of alfa-fetoprotein density in patients with hepatocellular carcinoma undergoing radiofrequency ablation
To examine the prognostic value of preoperative alfa-fetoprotein (AFP) density and other clinical factors in patients undergoing percutaneous radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC). From January 2010 to December 2018, a total of 543 patients undergoing RFA for HCC meeting th...
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| Veröffentlicht in: | International journal of hyperthermia 2022-12, Vol.39 (1), p.1143-1151 |
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| container_title | International journal of hyperthermia |
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| creator | Zhuang, Bo-Wen Li, Wei Qiao, Bin Zhang, Nan Lin, Man-Xia Wang, Wei Kuang, Ming Lu, Ming-De Xie, Xiao-Yan Xie, Xiao-Hua |
| description | To examine the prognostic value of preoperative alfa-fetoprotein (AFP) density and other clinical factors in patients undergoing percutaneous radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC).
From January 2010 to December 2018, a total of 543 patients undergoing RFA for HCC meeting the Milan criteria were included at our institution. AFP density was calculated as absolute AFP pre-ablation divided by the total volume of all HCC lesions. The survival rates according to AFP density were estimated using the Kaplan-Meier method and compared using the log-rank test. Univariate and multivariate Cox proportional-hazards regression analyses were used to assess predictors of overall survival (OS) and progression-free survival (PFS).
The Kaplan-Meier 1-, 3-, and 5-year OS rates were 98.8%, 88.5%, and 70.4%, respectively, for the low AFP density group, and 98.3%, 74.9%, and 49.4%, respectively, for the high AFP density group. The corresponding PFS rates were 78.9%, 56.7%, and 40.9% (low AFP density group), and 63.6%, 40.8%, and 27.5% (high AFP density group). High AFP density was associated with significantly reduced PFS and OS (both p |
| doi_str_mv | 10.1080/02656736.2022.2116491 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1080_02656736_2022_2116491</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_89b88b4c87ac47908243b93a54f43783</doaj_id><sourcerecordid>2708261933</sourcerecordid><originalsourceid>FETCH-LOGICAL-c456t-f0a08d49cc7263bc480b6573916b095b45b0b4d87188c6aa292b3fad76f8607c3</originalsourceid><addsrcrecordid>eNp9kc1uEzEUhUcIJELhEZC8ZDPB__bsQBWUSpXaBayta4-dunLsYE9a5QV4bjyksGTlv3O-q-MzDO8J3hKs8UdMpZCKyS3FlG4pIZJP5MWwIVzyURChXg6bVTOuotfDm9YeMMZcULUZft1VXw6-whIfPTrUssulLdGhR0hHj0pAkAKMwS-lPy4-ZjT73OJyQn176Dafl4ae4nKP7n0_F-dTOiaoyEF1MZc9oGOefd2VmHeowhxLqP7n0Wd3QmBTR5T8dngVIDX_7nm9GH58_fL98tt4c3t1ffn5ZnRcyGUMGLCe-eScopJZxzW2Uig2EWnxJCwXFls-a0W0dhKATtSyALOSQUusHLsYrs_cucCDOdS4h3oyBaL5c1HqzkDt8ZM3erJaW-60AsfVhDXlzE4MBA-cKc0668OZ1T-mx2mL2ce2pofsy7EZqrpHkomtUnGWulpaqz78G02wWTs0fzs0a4fmucPu-3T2xRxK3cNTqWk2C5xSqaFCdrEZ9n_Eb3s7pdw</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2708261933</pqid></control><display><type>article</type><title>Preoperative prognostic value of alfa-fetoprotein density in patients with hepatocellular carcinoma undergoing radiofrequency ablation</title><source>Taylor & Francis Open Access</source><source>DOAJ Directory of Open Access Journals</source><creator>Zhuang, Bo-Wen ; Li, Wei ; Qiao, Bin ; Zhang, Nan ; Lin, Man-Xia ; Wang, Wei ; Kuang, Ming ; Lu, Ming-De ; Xie, Xiao-Yan ; Xie, Xiao-Hua</creator><creatorcontrib>Zhuang, Bo-Wen ; Li, Wei ; Qiao, Bin ; Zhang, Nan ; Lin, Man-Xia ; Wang, Wei ; Kuang, Ming ; Lu, Ming-De ; Xie, Xiao-Yan ; Xie, Xiao-Hua</creatorcontrib><description>To examine the prognostic value of preoperative alfa-fetoprotein (AFP) density and other clinical factors in patients undergoing percutaneous radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC).
From January 2010 to December 2018, a total of 543 patients undergoing RFA for HCC meeting the Milan criteria were included at our institution. AFP density was calculated as absolute AFP pre-ablation divided by the total volume of all HCC lesions. The survival rates according to AFP density were estimated using the Kaplan-Meier method and compared using the log-rank test. Univariate and multivariate Cox proportional-hazards regression analyses were used to assess predictors of overall survival (OS) and progression-free survival (PFS).
The Kaplan-Meier 1-, 3-, and 5-year OS rates were 98.8%, 88.5%, and 70.4%, respectively, for the low AFP density group, and 98.3%, 74.9%, and 49.4%, respectively, for the high AFP density group. The corresponding PFS rates were 78.9%, 56.7%, and 40.9% (low AFP density group), and 63.6%, 40.8%, and 27.5% (high AFP density group). High AFP density was associated with significantly reduced PFS and OS (both p < 0.001). Multivariate analysis suggested that AFP density was a predictor of OS and PFS.
Serum AFP density may serve as a promising predictor of survival in patients with HCC undergoing RFA. High AFP density could identify patients who might be prone to recurrence or progression and need close surveillance.</description><identifier>ISSN: 0265-6736</identifier><identifier>EISSN: 1464-5157</identifier><identifier>DOI: 10.1080/02656736.2022.2116491</identifier><language>eng</language><publisher>Taylor & Francis</publisher><subject>alfa-fetoprotein ; Hepatocellular carcinoma ; overall survival ; progression-free survival ; radiofrequency ablation</subject><ispartof>International journal of hyperthermia, 2022-12, Vol.39 (1), p.1143-1151</ispartof><rights>2022 The Author(s). Published with license by Taylor & Francis Group, LLC. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-f0a08d49cc7263bc480b6573916b095b45b0b4d87188c6aa292b3fad76f8607c3</citedby><cites>FETCH-LOGICAL-c456t-f0a08d49cc7263bc480b6573916b095b45b0b4d87188c6aa292b3fad76f8607c3</cites><orcidid>0000-0003-0131-4848</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/02656736.2022.2116491$$EPDF$$P50$$Ginformaworld$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/02656736.2022.2116491$$EHTML$$P50$$Ginformaworld$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,860,2096,27479,27901,27902,59116,59117</link.rule.ids></links><search><creatorcontrib>Zhuang, Bo-Wen</creatorcontrib><creatorcontrib>Li, Wei</creatorcontrib><creatorcontrib>Qiao, Bin</creatorcontrib><creatorcontrib>Zhang, Nan</creatorcontrib><creatorcontrib>Lin, Man-Xia</creatorcontrib><creatorcontrib>Wang, Wei</creatorcontrib><creatorcontrib>Kuang, Ming</creatorcontrib><creatorcontrib>Lu, Ming-De</creatorcontrib><creatorcontrib>Xie, Xiao-Yan</creatorcontrib><creatorcontrib>Xie, Xiao-Hua</creatorcontrib><title>Preoperative prognostic value of alfa-fetoprotein density in patients with hepatocellular carcinoma undergoing radiofrequency ablation</title><title>International journal of hyperthermia</title><description>To examine the prognostic value of preoperative alfa-fetoprotein (AFP) density and other clinical factors in patients undergoing percutaneous radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC).
From January 2010 to December 2018, a total of 543 patients undergoing RFA for HCC meeting the Milan criteria were included at our institution. AFP density was calculated as absolute AFP pre-ablation divided by the total volume of all HCC lesions. The survival rates according to AFP density were estimated using the Kaplan-Meier method and compared using the log-rank test. Univariate and multivariate Cox proportional-hazards regression analyses were used to assess predictors of overall survival (OS) and progression-free survival (PFS).
The Kaplan-Meier 1-, 3-, and 5-year OS rates were 98.8%, 88.5%, and 70.4%, respectively, for the low AFP density group, and 98.3%, 74.9%, and 49.4%, respectively, for the high AFP density group. The corresponding PFS rates were 78.9%, 56.7%, and 40.9% (low AFP density group), and 63.6%, 40.8%, and 27.5% (high AFP density group). High AFP density was associated with significantly reduced PFS and OS (both p < 0.001). Multivariate analysis suggested that AFP density was a predictor of OS and PFS.
Serum AFP density may serve as a promising predictor of survival in patients with HCC undergoing RFA. High AFP density could identify patients who might be prone to recurrence or progression and need close surveillance.</description><subject>alfa-fetoprotein</subject><subject>Hepatocellular carcinoma</subject><subject>overall survival</subject><subject>progression-free survival</subject><subject>radiofrequency ablation</subject><issn>0265-6736</issn><issn>1464-5157</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>DOA</sourceid><recordid>eNp9kc1uEzEUhUcIJELhEZC8ZDPB__bsQBWUSpXaBayta4-dunLsYE9a5QV4bjyksGTlv3O-q-MzDO8J3hKs8UdMpZCKyS3FlG4pIZJP5MWwIVzyURChXg6bVTOuotfDm9YeMMZcULUZft1VXw6-whIfPTrUssulLdGhR0hHj0pAkAKMwS-lPy4-ZjT73OJyQn176Dafl4ae4nKP7n0_F-dTOiaoyEF1MZc9oGOefd2VmHeowhxLqP7n0Wd3QmBTR5T8dngVIDX_7nm9GH58_fL98tt4c3t1ffn5ZnRcyGUMGLCe-eScopJZxzW2Uig2EWnxJCwXFls-a0W0dhKATtSyALOSQUusHLsYrs_cucCDOdS4h3oyBaL5c1HqzkDt8ZM3erJaW-60AsfVhDXlzE4MBA-cKc0668OZ1T-mx2mL2ce2pofsy7EZqrpHkomtUnGWulpaqz78G02wWTs0fzs0a4fmucPu-3T2xRxK3cNTqWk2C5xSqaFCdrEZ9n_Eb3s7pdw</recordid><startdate>20221231</startdate><enddate>20221231</enddate><creator>Zhuang, Bo-Wen</creator><creator>Li, Wei</creator><creator>Qiao, Bin</creator><creator>Zhang, Nan</creator><creator>Lin, Man-Xia</creator><creator>Wang, Wei</creator><creator>Kuang, Ming</creator><creator>Lu, Ming-De</creator><creator>Xie, Xiao-Yan</creator><creator>Xie, Xiao-Hua</creator><general>Taylor & Francis</general><general>Taylor & Francis Group</general><scope>0YH</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-0131-4848</orcidid></search><sort><creationdate>20221231</creationdate><title>Preoperative prognostic value of alfa-fetoprotein density in patients with hepatocellular carcinoma undergoing radiofrequency ablation</title><author>Zhuang, Bo-Wen ; Li, Wei ; Qiao, Bin ; Zhang, Nan ; Lin, Man-Xia ; Wang, Wei ; Kuang, Ming ; Lu, Ming-De ; Xie, Xiao-Yan ; Xie, Xiao-Hua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-f0a08d49cc7263bc480b6573916b095b45b0b4d87188c6aa292b3fad76f8607c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>alfa-fetoprotein</topic><topic>Hepatocellular carcinoma</topic><topic>overall survival</topic><topic>progression-free survival</topic><topic>radiofrequency ablation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhuang, Bo-Wen</creatorcontrib><creatorcontrib>Li, Wei</creatorcontrib><creatorcontrib>Qiao, Bin</creatorcontrib><creatorcontrib>Zhang, Nan</creatorcontrib><creatorcontrib>Lin, Man-Xia</creatorcontrib><creatorcontrib>Wang, Wei</creatorcontrib><creatorcontrib>Kuang, Ming</creatorcontrib><creatorcontrib>Lu, Ming-De</creatorcontrib><creatorcontrib>Xie, Xiao-Yan</creatorcontrib><creatorcontrib>Xie, Xiao-Hua</creatorcontrib><collection>Taylor & Francis Open Access</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>International journal of hyperthermia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhuang, Bo-Wen</au><au>Li, Wei</au><au>Qiao, Bin</au><au>Zhang, Nan</au><au>Lin, Man-Xia</au><au>Wang, Wei</au><au>Kuang, Ming</au><au>Lu, Ming-De</au><au>Xie, Xiao-Yan</au><au>Xie, Xiao-Hua</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preoperative prognostic value of alfa-fetoprotein density in patients with hepatocellular carcinoma undergoing radiofrequency ablation</atitle><jtitle>International journal of hyperthermia</jtitle><date>2022-12-31</date><risdate>2022</risdate><volume>39</volume><issue>1</issue><spage>1143</spage><epage>1151</epage><pages>1143-1151</pages><issn>0265-6736</issn><eissn>1464-5157</eissn><abstract>To examine the prognostic value of preoperative alfa-fetoprotein (AFP) density and other clinical factors in patients undergoing percutaneous radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC).
From January 2010 to December 2018, a total of 543 patients undergoing RFA for HCC meeting the Milan criteria were included at our institution. AFP density was calculated as absolute AFP pre-ablation divided by the total volume of all HCC lesions. The survival rates according to AFP density were estimated using the Kaplan-Meier method and compared using the log-rank test. Univariate and multivariate Cox proportional-hazards regression analyses were used to assess predictors of overall survival (OS) and progression-free survival (PFS).
The Kaplan-Meier 1-, 3-, and 5-year OS rates were 98.8%, 88.5%, and 70.4%, respectively, for the low AFP density group, and 98.3%, 74.9%, and 49.4%, respectively, for the high AFP density group. The corresponding PFS rates were 78.9%, 56.7%, and 40.9% (low AFP density group), and 63.6%, 40.8%, and 27.5% (high AFP density group). High AFP density was associated with significantly reduced PFS and OS (both p < 0.001). Multivariate analysis suggested that AFP density was a predictor of OS and PFS.
Serum AFP density may serve as a promising predictor of survival in patients with HCC undergoing RFA. High AFP density could identify patients who might be prone to recurrence or progression and need close surveillance.</abstract><pub>Taylor & Francis</pub><doi>10.1080/02656736.2022.2116491</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-0131-4848</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | alfa-fetoprotein Hepatocellular carcinoma overall survival progression-free survival radiofrequency ablation |
| title | Preoperative prognostic value of alfa-fetoprotein density in patients with hepatocellular carcinoma undergoing radiofrequency ablation |
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