Induction of DNA-lesions in freshly isolated rat hepatocytes by different genotoxins and their reduction by lignin given either as a dietary component or in In vitro conditions

The aim of our investigation was to verify the protective effect of lignin on DNA in rat hepatocytes damaged by 3 different genotoxins attacking DNA in a different manner. Hydrogen peroxide was used for induction of direct single strand breaks of DNA, visible light-excited methylene blue for inducti...

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Veröffentlicht in:	Nutrition and cancer 2007-01, Vol.57 (2), p.209-215
Hauptverfasser:	Labaj, J, Slamenova, D, Lazarova, M, Kosikova, B
Format:	Artikel
Sprache:	eng
Schlagworte:	animal models Animals Antimutagenic Agents - administration & dosage Antimutagenic Agents - pharmacology Biological and medical sciences chemoprevention Comet Assay culture media cultured cells diet Diseases of the digestive system DNA damage DNA Damage - drug effects Dose-Response Relationship, Drug Epidemiology genotoxicity hepatocytes Hepatocytes - drug effects Hepatocytes - metabolism Humans Hydrogen Peroxide - toxicity in vitro studies lignin Lignin - administration & dosage Lignin - pharmacology Male Medical sciences Methylene Blue - toxicity Mutagens - toxicity Other treatments Oxidation-Reduction Propane - analogs & derivatives Propane - toxicity Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Rats Rats, Sprague-Dawley Time Factors Treatment. General aspects Tumors
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