APPLICATION OF HMBC AND HMQC-TOCSY NMR METHODS TO ASSIGN THE STRUCTURES OF BICYCLIC-PEPTIDE MIMETICS

The structures of representative bicyclic peptides are confirmed through the NMR methods of HMBC and HMQC-TOCSY. Complete assignment of proton and carbon resonances is afforded by these two-dimensional NMR methods. HMQC-TOCSY is especially useful for assigning spectra in molecules having extensive p...

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Veröffentlicht in:	Journal of coordination chemistry 1994-06, Vol.32 (1-3), p.135-144
Hauptverfasser:	D'avignon, D. André, Hanau, Cathleen E., Fobian, Yvette M., Moeller, Kevin D.
Format:	Artikel
Sprache:	eng
Schlagworte:	bicyclic peptides HMBC HMQC-TOCSY NMR
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description	The structures of representative bicyclic peptides are confirmed through the NMR methods of HMBC and HMQC-TOCSY. Complete assignment of proton and carbon resonances is afforded by these two-dimensional NMR methods. HMQC-TOCSY is especially useful for assigning spectra in molecules having extensive proton spin systems and in establishing connectivities between protonated carbons. Long-range proton-carbon connectivities obtained by HMBC confirm structure in molecules containing heteroatoms or non-protonated carbons that interrupt proton spin systems.
doi_str_mv	10.1080/00958979408024243
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André</creator><creator>Hanau, Cathleen E.</creator><creator>Fobian, Yvette M.</creator><creator>Moeller, Kevin D.</creator><general>Taylor & Francis Group</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19940601</creationdate><title>APPLICATION OF HMBC AND HMQC-TOCSY NMR METHODS TO ASSIGN THE STRUCTURES OF BICYCLIC-PEPTIDE MIMETICS</title><author>D'avignon, D. André ; Hanau, Cathleen E. ; Fobian, Yvette M. ; Moeller, Kevin D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c296t-de85e363daf3530227c54554599ab4894b368f1d40cb80a1dd21d3193216a82c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>bicyclic peptides</topic><topic>HMBC</topic><topic>HMQC-TOCSY</topic><topic>NMR</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>D'avignon, D. André</creatorcontrib><creatorcontrib>Hanau, Cathleen E.</creatorcontrib><creatorcontrib>Fobian, Yvette M.</creatorcontrib><creatorcontrib>Moeller, Kevin D.</creatorcontrib><collection>CrossRef</collection><jtitle>Journal of coordination chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>D'avignon, D. 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Long-range proton-carbon connectivities obtained by HMBC confirm structure in molecules containing heteroatoms or non-protonated carbons that interrupt proton spin systems.</abstract><pub>Taylor & Francis Group</pub><doi>10.1080/00958979408024243</doi><tpages>10</tpages></addata></record>
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subjects	bicyclic peptides HMBC HMQC-TOCSY NMR
title	APPLICATION OF HMBC AND HMQC-TOCSY NMR METHODS TO ASSIGN THE STRUCTURES OF BICYCLIC-PEPTIDE MIMETICS
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