Comparative metabolism of ortho-phenylphenol in mouse, rat and man

1. Ortho-phenylphenol (OPP) was well absorbed in the male B6C3F1 mouse, with 84 and 98% of the administered radioactivity recovered in the 0-48-h urine of animals administered a single oraldose of 15 or 800 mg/kg respectively. High absorption and rapid elimination were also seen in the female and ma...

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Veröffentlicht in:	Xenobiotica 1998, Vol.28 (6), p.579-594
Hauptverfasser:	BARTELS, M. J., McNETT, D. A., TIMCHALK, C., MENDRALA, A. L., CHRISTENSON, W. R., SANGHA, G. K., BRZAK, K. A., SHABRANG, S. N.
Format:	Artikel
Sprache:	eng
Schlagworte:	absorption Animals Biological and medical sciences Biotransformation Biphenyl Compounds - pharmacokinetics Biphenyl Compounds - urine Carbon Radioisotopes Carcinogens - pharmacokinetics Chemical and industrial products toxicology. Toxic occupational diseases chemical structure Chromatography, High Pressure Liquid excretion Female fungicides Gas Chromatography-Mass Spectrometry Glucuronates - urine Humans Intestinal Absorption Male Medical sciences metabolism metabolites Mice Mice, Inbred Strains oral administration Rats Rats, Inbred F344 skin species differences Species Specificity Spectrometry, Mass, Secondary Ion Toxicology urine Various organic compounds
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