Effect of Schisandra chinensis extract and Ginkgo biloba extract on the pharmacokinetics of talinolol in healthy volunteers

The authors investigated the effect of herbal medicine Schisandra chinensis extract (SchE) and Ginkgo biloba extract (GBE) on the oral pharmacokinetics of P-glycoprotein substrate talinolol in humans. Twelve healthy male volunteers took a single 100-mg oral dose of talinolol either alone or after pr...

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Veröffentlicht in:	Xenobiotica 2009-03, Vol.39 (3), p.249-254
Hauptverfasser:	Fan, L., Mao, X.-Q., Tao, G.-Y., Wang, G., Jiang, F., Chen, Y., Li, Q., Zhang, W., Lei, H.-P., Hu, D.-L., Huang, Y.-F., Wang, D., Zhou, H.-H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Area Under Curve ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors China Chromatography, High Pressure Liquid Ginkgo biloba - chemistry Ginkgo biloba extract herb-drug interaction Humans inhibition Male p-glycoprotein pharmacokinetics Plant Extracts - pharmacology Propanolamines - administration & dosage Propanolamines - blood Propanolamines - pharmacokinetics Schisandra - chemistry Schisandra chinensis extract talinolol
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