CYP2A13 genetic polymorphism in French Caucasian, Gabonese and Tunisian populations
Since human CYP2A13 is expressed in the respiratory tract and is involved in the activation of tobacco-specific nitrosamines, some of the previously reported sequence variations may contribute to inter-individual and inter-ethnic differences in the susceptibility of tobacco-related tumorigenesis. Th...
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| Veröffentlicht in: | Xenobiotica 2005-07, Vol.35 (7), p.661-669 |
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| container_title | Xenobiotica |
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| creator | Cauffiez, C. Pottier, N. Tournel, G. Lo-Guidice, J.-M. Allorge, D. Chevalier, D. Migot-Nabias, F. Kenani, A. Broly, F. |
| description | Since human CYP2A13 is expressed in the respiratory tract and is involved in the activation of tobacco-specific nitrosamines, some of the previously reported sequence variations may contribute to inter-individual and inter-ethnic differences in the susceptibility of tobacco-related tumorigenesis. The aim was to compare the frequencies of the 578C > T (Arg101Stop), 3375C > T (Arg257Cys) and 7520C > G (3′-untranslated region) mutations in several populations. The frequencies of the 578C > T polymorphism were 3.8, 0 and 1.0% in French Caucasians, Gabonese and Tunisians, respectively. In the same populations, the frequencies of the 3375C > T mutation were 0, 15.3 and 4.2%, respectively, whereas the frequencies of the 7520C > G mutation were 1.0, 20.8 and 7.3%, respectively. Marked inter-ethnic variations in CYP2A13 were identified and confirmed. These findings provide data for further studies that associate CYP2A13 haplotypes with an incidence of smoking-related tumours in respect of ethnicity. |
| doi_str_mv | 10.1080/00498250500202171 |
| format | Article |
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The aim was to compare the frequencies of the 578C > T (Arg101Stop), 3375C > T (Arg257Cys) and 7520C > G (3′-untranslated region) mutations in several populations. The frequencies of the 578C > T polymorphism were 3.8, 0 and 1.0% in French Caucasians, Gabonese and Tunisians, respectively. In the same populations, the frequencies of the 3375C > T mutation were 0, 15.3 and 4.2%, respectively, whereas the frequencies of the 7520C > G mutation were 1.0, 20.8 and 7.3%, respectively. Marked inter-ethnic variations in CYP2A13 were identified and confirmed. These findings provide data for further studies that associate CYP2A13 haplotypes with an incidence of smoking-related tumours in respect of ethnicity.</description><identifier>ISSN: 0049-8254</identifier><identifier>EISSN: 1366-5928</identifier><identifier>DOI: 10.1080/00498250500202171</identifier><identifier>PMID: 16316926</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>3' Untranslated Regions - genetics ; African Continental Ancestry Group ; Aryl Hydrocarbon Hydroxylases - genetics ; Codon, Terminator - genetics ; CYP2A13 ; Cytochrome P450 ; European Continental Ancestry Group ; Gene Frequency ; genetic polymorphism ; Genetic Predisposition to Disease ; Genotype ; Haplotypes ; Humans ; Neoplasms - chemically induced ; Neoplasms - genetics ; Point Mutation ; Polymorphism, Genetic ; Smoking - adverse effects ; Smoking - genetics</subject><ispartof>Xenobiotica, 2005-07, Vol.35 (7), p.661-669</ispartof><rights>2005 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c435t-8e5454a11240a22eb096f6b9d847f38f000a1a5344ede72a08205a8fca6907e33</citedby><cites>FETCH-LOGICAL-c435t-8e5454a11240a22eb096f6b9d847f38f000a1a5344ede72a08205a8fca6907e33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/00498250500202171$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/00498250500202171$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,59620,59726,60409,60515,61194,61229,61375,61410</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16316926$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cauffiez, C.</creatorcontrib><creatorcontrib>Pottier, N.</creatorcontrib><creatorcontrib>Tournel, G.</creatorcontrib><creatorcontrib>Lo-Guidice, J.-M.</creatorcontrib><creatorcontrib>Allorge, D.</creatorcontrib><creatorcontrib>Chevalier, D.</creatorcontrib><creatorcontrib>Migot-Nabias, F.</creatorcontrib><creatorcontrib>Kenani, A.</creatorcontrib><creatorcontrib>Broly, F.</creatorcontrib><title>CYP2A13 genetic polymorphism in French Caucasian, Gabonese and Tunisian populations</title><title>Xenobiotica</title><addtitle>Xenobiotica</addtitle><description>Since human CYP2A13 is expressed in the respiratory tract and is involved in the activation of tobacco-specific nitrosamines, some of the previously reported sequence variations may contribute to inter-individual and inter-ethnic differences in the susceptibility of tobacco-related tumorigenesis. The aim was to compare the frequencies of the 578C > T (Arg101Stop), 3375C > T (Arg257Cys) and 7520C > G (3′-untranslated region) mutations in several populations. The frequencies of the 578C > T polymorphism were 3.8, 0 and 1.0% in French Caucasians, Gabonese and Tunisians, respectively. In the same populations, the frequencies of the 3375C > T mutation were 0, 15.3 and 4.2%, respectively, whereas the frequencies of the 7520C > G mutation were 1.0, 20.8 and 7.3%, respectively. Marked inter-ethnic variations in CYP2A13 were identified and confirmed. These findings provide data for further studies that associate CYP2A13 haplotypes with an incidence of smoking-related tumours in respect of ethnicity.</description><subject>3' Untranslated Regions - genetics</subject><subject>African Continental Ancestry Group</subject><subject>Aryl Hydrocarbon Hydroxylases - genetics</subject><subject>Codon, Terminator - genetics</subject><subject>CYP2A13</subject><subject>Cytochrome P450</subject><subject>European Continental Ancestry Group</subject><subject>Gene Frequency</subject><subject>genetic polymorphism</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Haplotypes</subject><subject>Humans</subject><subject>Neoplasms - chemically induced</subject><subject>Neoplasms - genetics</subject><subject>Point Mutation</subject><subject>Polymorphism, Genetic</subject><subject>Smoking - adverse effects</subject><subject>Smoking - genetics</subject><issn>0049-8254</issn><issn>1366-5928</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LHEEQhhuJ6MbkB3iROeXkJNUf0zODXmRRExAMxBxyamp7atyWme6xewbZf-8suyAS8FRQ9bwvxcPYKYfvHCr4AaDqShRQAAgQvOQHbMGl1nlRi-oTW2zv-QyoY_Y5pScA0FyII3bMteS6FnrB_iz__RZXXGaP5Gl0NhtCt-lDHNYu9Znz2U0kb9fZEieLyaE_z25xFTwlytA32cPk3XY954apw9EFn76wwxa7RF_384T9vbl-WP7M7-5vfy2v7nKrZDHmFRWqUMi5UIBC0Apq3epV3VSqbGXVzu8ix0IqRQ2VAqESUGDVWtQ1lCTlCfu26x1ieJ4ojaZ3yVLXoacwJcNLJTkoPYN8B9oYUorUmiG6HuPGcDBbk-Y_k3PmbF8-rXpq3hJ7dTNwuQOcb0Ps8SXErjEjbroQ24jeumTkR_0X7-Jrwm5cW4xknsIU_Szug-9eAXFtkbY</recordid><startdate>20050701</startdate><enddate>20050701</enddate><creator>Cauffiez, C.</creator><creator>Pottier, N.</creator><creator>Tournel, G.</creator><creator>Lo-Guidice, J.-M.</creator><creator>Allorge, D.</creator><creator>Chevalier, D.</creator><creator>Migot-Nabias, F.</creator><creator>Kenani, A.</creator><creator>Broly, F.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20050701</creationdate><title>CYP2A13 genetic polymorphism in French Caucasian, Gabonese and Tunisian populations</title><author>Cauffiez, C. ; Pottier, N. ; Tournel, G. ; Lo-Guidice, J.-M. ; Allorge, D. ; Chevalier, D. ; Migot-Nabias, F. ; Kenani, A. ; Broly, F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-8e5454a11240a22eb096f6b9d847f38f000a1a5344ede72a08205a8fca6907e33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>3' Untranslated Regions - genetics</topic><topic>African Continental Ancestry Group</topic><topic>Aryl Hydrocarbon Hydroxylases - genetics</topic><topic>Codon, Terminator - genetics</topic><topic>CYP2A13</topic><topic>Cytochrome P450</topic><topic>European Continental Ancestry Group</topic><topic>Gene Frequency</topic><topic>genetic polymorphism</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Haplotypes</topic><topic>Humans</topic><topic>Neoplasms - chemically induced</topic><topic>Neoplasms - genetics</topic><topic>Point Mutation</topic><topic>Polymorphism, Genetic</topic><topic>Smoking - adverse effects</topic><topic>Smoking - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cauffiez, C.</creatorcontrib><creatorcontrib>Pottier, N.</creatorcontrib><creatorcontrib>Tournel, G.</creatorcontrib><creatorcontrib>Lo-Guidice, J.-M.</creatorcontrib><creatorcontrib>Allorge, D.</creatorcontrib><creatorcontrib>Chevalier, D.</creatorcontrib><creatorcontrib>Migot-Nabias, F.</creatorcontrib><creatorcontrib>Kenani, A.</creatorcontrib><creatorcontrib>Broly, F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Xenobiotica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cauffiez, C.</au><au>Pottier, N.</au><au>Tournel, G.</au><au>Lo-Guidice, J.-M.</au><au>Allorge, D.</au><au>Chevalier, D.</au><au>Migot-Nabias, F.</au><au>Kenani, A.</au><au>Broly, F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CYP2A13 genetic polymorphism in French Caucasian, Gabonese and Tunisian populations</atitle><jtitle>Xenobiotica</jtitle><addtitle>Xenobiotica</addtitle><date>2005-07-01</date><risdate>2005</risdate><volume>35</volume><issue>7</issue><spage>661</spage><epage>669</epage><pages>661-669</pages><issn>0049-8254</issn><eissn>1366-5928</eissn><abstract>Since human CYP2A13 is expressed in the respiratory tract and is involved in the activation of tobacco-specific nitrosamines, some of the previously reported sequence variations may contribute to inter-individual and inter-ethnic differences in the susceptibility of tobacco-related tumorigenesis. The aim was to compare the frequencies of the 578C > T (Arg101Stop), 3375C > T (Arg257Cys) and 7520C > G (3′-untranslated region) mutations in several populations. The frequencies of the 578C > T polymorphism were 3.8, 0 and 1.0% in French Caucasians, Gabonese and Tunisians, respectively. In the same populations, the frequencies of the 3375C > T mutation were 0, 15.3 and 4.2%, respectively, whereas the frequencies of the 7520C > G mutation were 1.0, 20.8 and 7.3%, respectively. Marked inter-ethnic variations in CYP2A13 were identified and confirmed. These findings provide data for further studies that associate CYP2A13 haplotypes with an incidence of smoking-related tumours in respect of ethnicity.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>16316926</pmid><doi>10.1080/00498250500202171</doi><tpages>9</tpages></addata></record> |
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| source | Taylor & Francis; MEDLINE; Taylor & Francis Medical Library - CRKN |
| subjects | 3' Untranslated Regions - genetics African Continental Ancestry Group Aryl Hydrocarbon Hydroxylases - genetics Codon, Terminator - genetics CYP2A13 Cytochrome P450 European Continental Ancestry Group Gene Frequency genetic polymorphism Genetic Predisposition to Disease Genotype Haplotypes Humans Neoplasms - chemically induced Neoplasms - genetics Point Mutation Polymorphism, Genetic Smoking - adverse effects Smoking - genetics |
| title | CYP2A13 genetic polymorphism in French Caucasian, Gabonese and Tunisian populations |
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