Identification of novel metabolites of pioglitazone in rat and dog

1. Four new metabolites of pioglitazone were identified by liquid chromatography-mass spectrometry (LC-MS/MS) as being formed by hydroxylation (M-VII and M-VIII), opening of the thiazolidinedione ring (M-X) and by desaturation of the terminal ethyl side chain or tether ethoxy moiety (M-IX), respecti...

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Veröffentlicht in:	Xenobiotica 2003-05, Vol.33 (5), p.499-509
Hauptverfasser:	Shen, Z., Reed, J. R., Creighton, M., Liu, D. Q., Tang, Y. S., Hora, D. F., Feeney, W., Szewczyk, J., Bakhtiar, R., Franklin, R. B., Vincent, S. H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bile - metabolism Biological and medical sciences Chromatography, Liquid - methods Dogs General and cellular metabolism. Vitamins Humans Hydroxylation Kidney - metabolism Mass Spectrometry - methods Medical sciences Microsomes - metabolism Microsomes, Liver - metabolism Oxidation-Reduction Pharmacology. Drug treatments Pioglitazone Rats Thiazolidinediones - blood Thiazolidinediones - chemistry Thiazolidinediones - metabolism Thiazolidinediones - urine Tritium
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