Robust Analysis of High Throughput Screening (HTS) Assay Data

Quantitative high throughput screening (qHTS) assays use cells or tissues to screen thousands of compounds in a short period of time. Data generated from qHTS assays are then evaluated using nonlinear regression models, such as the Hill model, and decisions regarding toxicity are made using the esti...

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Veröffentlicht in:	Technometrics 2013-05, Vol.55 (2), p.150-160
Hauptverfasser:	Lim, Changwon, Sen, Pranab K., Peddada, Shyamal D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cells Chemicals Dose-response study False discovery rate (FDR) Heteroscedasticity Hill model M-estimation procedure Nonlinear regression model Power Regression analysis Simulation Tissues Toxicity Toxicology
Online-Zugang:	Volltext
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