Regioselective Synthesis of New Triheterocyclic Compounds from 1,4-Benzodiazepine

Regioselective Synthesis of New Triheterocyclic Compounds from 1,4-Benzodiazepine

As part of our program on the synthesis of new heterocyclic compounds, we report here a one-step synthesis of [1,2,4]triazolo[4,3-d][1,4]benzodiazepine 3 and [1,2,4]oxadiazolo[4,5-d][1,4]benzodiazepine 5 by 1,3-dipolar cycloaddition of nitrilimines and nitrile oxides with 1,4-benzodiazepines 1.

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Veröffentlicht in:Synthetic communications 1998-11, Vol.28 (22), p.4221-4232
Hauptverfasser: Benelbaghdadi, R., Hasnaoui, A., Lavergne, J.-P., Giorgi, M., Pierrot, M.
Format: Artikel
Sprache:eng
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Zusammenfassung:As part of our program on the synthesis of new heterocyclic compounds, we report here a one-step synthesis of [1,2,4]triazolo[4,3-d][1,4]benzodiazepine 3 and [1,2,4]oxadiazolo[4,5-d][1,4]benzodiazepine 5 by 1,3-dipolar cycloaddition of nitrilimines and nitrile oxides with 1,4-benzodiazepines 1.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397919809458703