Synthesis and NMR Characterization of Monomethoxypoly(Ethylene Glycol) Aldehydes from Monomethoxypoly(Ethylene Glycol) Tosylates

Synthesis and NMR Characterization of Monomethoxypoly(Ethylene Glycol) Aldehydes from Monomethoxypoly(Ethylene Glycol) Tosylates

A procedure for the synthesis of monomethoxypoly(ethylene glycol) aldehydes from monomethoxypoly(ethylene glycol) tosylates is described. The tosylates are converted to aldehydes in high yield via treatment with disodium hydrogen phosphate and DMSO; minimal oligomeric by-products are formed.

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Veröffentlicht in:Synthetic communications 1998-11, Vol.28 (22), p.4143-4149
Hauptverfasser: Ladd, David L., Henrichs, P. Mark
Format: Artikel
Sprache:eng
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Zusammenfassung:A procedure for the synthesis of monomethoxypoly(ethylene glycol) aldehydes from monomethoxypoly(ethylene glycol) tosylates is described. The tosylates are converted to aldehydes in high yield via treatment with disodium hydrogen phosphate and DMSO; minimal oligomeric by-products are formed.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397919809458693