Facile Hydration of Nitriles to Amides Using Potassium Fluoride on Alumina

The selective hydration of nitriles to yield anides is a synthetically useful reaction 1 . This transformation has been brought about by varius reagents like, for example, mineral acids 2 , hydrogen halides in alcohols 3 , alkaline hydrogen peroxide 4 , alkaline hydrogen peroxide under phase transfe...

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Veröffentlicht in:Synthetic communications 1982-01, Vol.12 (3), p.177-181
1. Verfasser: Rao, C. Gundu
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description The selective hydration of nitriles to yield anides is a synthetically useful reaction 1 . This transformation has been brought about by varius reagents like, for example, mineral acids 2 , hydrogen halides in alcohols 3 , alkaline hydrogen peroxide 4 , alkaline hydrogen peroxide under phase transfer conditions 5 , sodium super-oxide in DMSO 6 , basic anion exchange resins 7 manganese dioxide 8 , and complexes containing transition metals 9 and noble metals 10 .
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title Facile Hydration of Nitriles to Amides Using Potassium Fluoride on Alumina
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