Prolonged and Profound Acid Inhibition Is Crucial in Helicobacter pylori Treatment with a Proton Pump Inhibitor Combined with Amoxicillin
Background: The aim was to investigate whether intragastric pH, meal-stimulated gastrin release, or demographic factors predict the outcome of Helicobacter pylori treatment. Methods: Thirty-six patients with H. pylori infection were investigated with 24-h intragastric pH registration and meal-stimul...
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| Veröffentlicht in: | Scandinavian journal of gastroenterology 1998, Vol.33 (1), p.39-43 |
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| container_title | Scandinavian journal of gastroenterology |
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| creator | S. SJÖSTEDT, M. SAGAR, G. LINDBERG, B. WIKSTRÖM, C. E. NORD, R. SEENSALU |
| description | Background: The aim was to investigate whether intragastric pH, meal-stimulated gastrin release, or demographic factors predict the outcome of Helicobacter pylori treatment. Methods: Thirty-six patients with H. pylori infection were investigated with 24-h intragastric pH registration and meal-stimulated gastrin release before and during treatment with 20 mg omeprazole twice daily and 750 mg amoxicillin twice daily for 14 days. The influence of age, sex, smoking, ethnic origin, pH, and gastrin on treatment outcome were analysed with logistic regression. Results: Eradication of H. pylori was achieved in 18 of 34 (53%) patients. The univariate analysis showed that age, ethnic origin, more than 84.2% of the time with pH above 4, and continuous periods longer than 156 min with intragastric pH above 6 were significantly associated with successful treatment of H. pylori. In the multivariate analysis only the two pH variables were found to be independent factors for predicting treatment outcome. Conclusion: The outcome of H. pylori treatment with omeprazole and amoxicillin may depend on several factors, such as age, ethnic origin, and a pronounced acid suppression. However, the only factor of independent importance in this study was prolonged and profound acid inhibition. |
| doi_str_mv | 10.1080/00365529850166185 |
| format | Article |
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SJÖSTEDT, M. SAGAR, G. LINDBERG, B. WIKSTRÖM, C. E. NORD, R. SEENSALU</creator><creatorcontrib>S. SJÖSTEDT, M. SAGAR, G. LINDBERG, B. WIKSTRÖM, C. E. NORD, R. SEENSALU</creatorcontrib><description>Background: The aim was to investigate whether intragastric pH, meal-stimulated gastrin release, or demographic factors predict the outcome of Helicobacter pylori treatment. Methods: Thirty-six patients with H. pylori infection were investigated with 24-h intragastric pH registration and meal-stimulated gastrin release before and during treatment with 20 mg omeprazole twice daily and 750 mg amoxicillin twice daily for 14 days. The influence of age, sex, smoking, ethnic origin, pH, and gastrin on treatment outcome were analysed with logistic regression. Results: Eradication of H. pylori was achieved in 18 of 34 (53%) patients. The univariate analysis showed that age, ethnic origin, more than 84.2% of the time with pH above 4, and continuous periods longer than 156 min with intragastric pH above 6 were significantly associated with successful treatment of H. pylori. In the multivariate analysis only the two pH variables were found to be independent factors for predicting treatment outcome. Conclusion: The outcome of H. pylori treatment with omeprazole and amoxicillin may depend on several factors, such as age, ethnic origin, and a pronounced acid suppression. However, the only factor of independent importance in this study was prolonged and profound acid inhibition.</description><identifier>ISSN: 0036-5521</identifier><identifier>EISSN: 1502-7708</identifier><identifier>DOI: 10.1080/00365529850166185</identifier><identifier>PMID: 9489906</identifier><identifier>CODEN: SJGRA4</identifier><language>eng</language><publisher>Copenhagen: Informa UK Ltd</publisher><subject>Adult ; Age Factors ; Aged ; Aged, 80 and over ; Amoxicillin - therapeutic use ; Anti-Ulcer Agents - therapeutic use ; Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Biological and medical sciences ; Drug Therapy, Combination ; Female ; Helicobacter Infections - drug therapy ; Helicobacter Infections - ethnology ; Helicobacter Infections - microbiology ; Helicobacter pylori ; Humans ; Logistic Models ; Male ; Medical sciences ; Middle Aged ; Omeprazole - therapeutic use ; Penicillins - therapeutic use ; Pharmacology. 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SJÖSTEDT, M. SAGAR, G. LINDBERG, B. WIKSTRÖM, C. E. NORD, R. SEENSALU</creatorcontrib><title>Prolonged and Profound Acid Inhibition Is Crucial in Helicobacter pylori Treatment with a Proton Pump Inhibitor Combined with Amoxicillin</title><title>Scandinavian journal of gastroenterology</title><addtitle>Scand J Gastroenterol</addtitle><description>Background: The aim was to investigate whether intragastric pH, meal-stimulated gastrin release, or demographic factors predict the outcome of Helicobacter pylori treatment. Methods: Thirty-six patients with H. pylori infection were investigated with 24-h intragastric pH registration and meal-stimulated gastrin release before and during treatment with 20 mg omeprazole twice daily and 750 mg amoxicillin twice daily for 14 days. The influence of age, sex, smoking, ethnic origin, pH, and gastrin on treatment outcome were analysed with logistic regression. Results: Eradication of H. pylori was achieved in 18 of 34 (53%) patients. The univariate analysis showed that age, ethnic origin, more than 84.2% of the time with pH above 4, and continuous periods longer than 156 min with intragastric pH above 6 were significantly associated with successful treatment of H. pylori. In the multivariate analysis only the two pH variables were found to be independent factors for predicting treatment outcome. Conclusion: The outcome of H. pylori treatment with omeprazole and amoxicillin may depend on several factors, such as age, ethnic origin, and a pronounced acid suppression. However, the only factor of independent importance in this study was prolonged and profound acid inhibition.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Amoxicillin - therapeutic use</subject><subject>Anti-Ulcer Agents - therapeutic use</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Biological and medical sciences</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>Helicobacter Infections - drug therapy</subject><subject>Helicobacter Infections - ethnology</subject><subject>Helicobacter Infections - microbiology</subject><subject>Helicobacter pylori</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Omeprazole - therapeutic use</subject><subject>Penicillins - therapeutic use</subject><subject>Pharmacology. Drug treatments</subject><subject>Proton Pumps</subject><subject>Sex Factors</subject><subject>Treatment Outcome</subject><issn>0036-5521</issn><issn>1502-7708</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFu1DAURSMEKtPCB7BA8gKxC9ixHSeCzWhE6UiV6KKsrRfHYVwce7AdTfsJ_DUOk46EkLrys9-599m-RfGG4A8EN_gjxrTmvGobjkldk4Y_K1aE46oUAjfPi9XcLzNAXhbnMd5hjLlg7Vlx1rKmbXG9Kn7fBG-9-6F7BK5HeTf4KRdrZXq0dTvTmWS8Q9uINmFSBiwyDl1pa5TvQCUd0P7B-mDQbdCQRu0SOpi0QzB7pay8mcb9o5MPaOPHzrg87i-1Hv29UcZa414VLwawUb9e1ovi--WX281Vef3t63azvi4Vq5tUqrqjQ19p1hHekbphLe2F4Fxx1oEgFFeEDbpWlHPRVmRoQACA7qmoaE0HSi-K8ugbD3o_dXIfzAjhQXowcjn6mSstGeX5SzP__sjvg_816ZjkaKLS1oLTfopStAILxmaQHEEVfIxBDydrguUcl_wvrqx5u5hP3aj7k2LJJ_ffLX2ICuwQwCkTT1hFKGFcZOzzETNu8GGEgw-2lwnmZB419KlbfPpHvtNg005B0PLOT8HlOJ54wx-TyMO4</recordid><startdate>1998</startdate><enddate>1998</enddate><creator>S. SJÖSTEDT, M. SAGAR, G. LINDBERG, B. WIKSTRÖM, C. E. NORD, R. SEENSALU</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Scandinavian University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>1998</creationdate><title>Prolonged and Profound Acid Inhibition Is Crucial in Helicobacter pylori Treatment with a Proton Pump Inhibitor Combined with Amoxicillin</title><author>S. SJÖSTEDT, M. SAGAR, G. LINDBERG, B. WIKSTRÖM, C. E. NORD, R. SEENSALU</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-c6b3fd2e4b15b168493d7755c54ba7130214fe6c3557921f8a7aaaed372363f33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Amoxicillin - therapeutic use</topic><topic>Anti-Ulcer Agents - therapeutic use</topic><topic>Antibacterial agents</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Biological and medical sciences</topic><topic>Drug Therapy, Combination</topic><topic>Female</topic><topic>Helicobacter Infections - drug therapy</topic><topic>Helicobacter Infections - ethnology</topic><topic>Helicobacter Infections - microbiology</topic><topic>Helicobacter pylori</topic><topic>Humans</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Omeprazole - therapeutic use</topic><topic>Penicillins - therapeutic use</topic><topic>Pharmacology. Drug treatments</topic><topic>Proton Pumps</topic><topic>Sex Factors</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>S. SJÖSTEDT, M. SAGAR, G. LINDBERG, B. WIKSTRÖM, C. E. NORD, R. SEENSALU</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Scandinavian journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>S. SJÖSTEDT, M. SAGAR, G. LINDBERG, B. WIKSTRÖM, C. E. NORD, R. SEENSALU</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prolonged and Profound Acid Inhibition Is Crucial in Helicobacter pylori Treatment with a Proton Pump Inhibitor Combined with Amoxicillin</atitle><jtitle>Scandinavian journal of gastroenterology</jtitle><addtitle>Scand J Gastroenterol</addtitle><date>1998</date><risdate>1998</risdate><volume>33</volume><issue>1</issue><spage>39</spage><epage>43</epage><pages>39-43</pages><issn>0036-5521</issn><eissn>1502-7708</eissn><coden>SJGRA4</coden><abstract>Background: The aim was to investigate whether intragastric pH, meal-stimulated gastrin release, or demographic factors predict the outcome of Helicobacter pylori treatment. Methods: Thirty-six patients with H. pylori infection were investigated with 24-h intragastric pH registration and meal-stimulated gastrin release before and during treatment with 20 mg omeprazole twice daily and 750 mg amoxicillin twice daily for 14 days. The influence of age, sex, smoking, ethnic origin, pH, and gastrin on treatment outcome were analysed with logistic regression. Results: Eradication of H. pylori was achieved in 18 of 34 (53%) patients. The univariate analysis showed that age, ethnic origin, more than 84.2% of the time with pH above 4, and continuous periods longer than 156 min with intragastric pH above 6 were significantly associated with successful treatment of H. pylori. In the multivariate analysis only the two pH variables were found to be independent factors for predicting treatment outcome. Conclusion: The outcome of H. pylori treatment with omeprazole and amoxicillin may depend on several factors, such as age, ethnic origin, and a pronounced acid suppression. However, the only factor of independent importance in this study was prolonged and profound acid inhibition.</abstract><cop>Copenhagen</cop><cop>Oslo</cop><cop>Stockholm</cop><pub>Informa UK Ltd</pub><pmid>9489906</pmid><doi>10.1080/00365529850166185</doi><tpages>5</tpages></addata></record> |
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| ispartof | Scandinavian journal of gastroenterology, 1998, Vol.33 (1), p.39-43 |
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| source | MEDLINE; Taylor & Francis:Master (3349 titles); Taylor & Francis Medical Library - CRKN |
| subjects | Adult Age Factors Aged Aged, 80 and over Amoxicillin - therapeutic use Anti-Ulcer Agents - therapeutic use Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Drug Therapy, Combination Female Helicobacter Infections - drug therapy Helicobacter Infections - ethnology Helicobacter Infections - microbiology Helicobacter pylori Humans Logistic Models Male Medical sciences Middle Aged Omeprazole - therapeutic use Penicillins - therapeutic use Pharmacology. Drug treatments Proton Pumps Sex Factors Treatment Outcome |
| title | Prolonged and Profound Acid Inhibition Is Crucial in Helicobacter pylori Treatment with a Proton Pump Inhibitor Combined with Amoxicillin |
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