Effectiveness of Diazepam and Methylphenidate in Multiple Dosages in Modifying Infant Trauma Effects
Albino rats in independent studies were administered varying dosages of diazepam and methylphenidate prior to a daily shock traumatization experience in infancy. All animals were tested on avoidance conditioning in adulthood. Both drugs were found to be effective in modifying the typically obtained...
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| Veröffentlicht in: | The Journal of general psychology 1973-01, Vol.88 (1), p.3-12 |
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| container_title | The Journal of general psychology |
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| creator | Gauron, Eugene F. Rowley, Vinton N. |
| description | Albino rats in independent studies were administered varying dosages of diazepam and methylphenidate prior to a daily shock traumatization experience in infancy. All animals were tested on avoidance conditioning in adulthood. Both drugs were found to be effective in modifying the typically obtained shock deficit. The results failed to substantiate that increased dosage level resulted in more effective modification of trauma effects. Delayed consequences of methylphenidate administration included modification of central nervous system reactivity as manifested in quicker reaction times and growth depression as manifested in lessened body weights in this group in comparison to the diazepam group. An additional feature of the study was the finding that male and female animals responded differently to the drug and shock experiences. |
| doi_str_mv | 10.1080/00221309.1973.9920703 |
| format | Article |
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All animals were tested on avoidance conditioning in adulthood. Both drugs were found to be effective in modifying the typically obtained shock deficit. The results failed to substantiate that increased dosage level resulted in more effective modification of trauma effects. Delayed consequences of methylphenidate administration included modification of central nervous system reactivity as manifested in quicker reaction times and growth depression as manifested in lessened body weights in this group in comparison to the diazepam group. 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All animals were tested on avoidance conditioning in adulthood. Both drugs were found to be effective in modifying the typically obtained shock deficit. The results failed to substantiate that increased dosage level resulted in more effective modification of trauma effects. Delayed consequences of methylphenidate administration included modification of central nervous system reactivity as manifested in quicker reaction times and growth depression as manifested in lessened body weights in this group in comparison to the diazepam group. An additional feature of the study was the finding that male and female animals responded differently to the drug and shock experiences.</abstract><cop>United States</cop><pub>Taylor & Francis Group</pub><pmid>4689150</pmid><doi>10.1080/00221309.1973.9920703</doi><tpages>10</tpages></addata></record> |
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| ispartof | The Journal of general psychology, 1973-01, Vol.88 (1), p.3-12 |
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| source | MEDLINE; Alma/SFX Local Collection; Periodicals Index Online |
| subjects | Animals Animals, Newborn Avoidance Learning - drug effects Body Weight - drug effects Conditioning, Classical Diazepam - administration & dosage Diazepam - pharmacology Dose-Response Relationship, Drug Electroshock Female Growth - drug effects Housing, Animal Male Methylphenidate - administration & dosage Methylphenidate - pharmacology Rats Reaction Time - drug effects Sex Factors |
| title | Effectiveness of Diazepam and Methylphenidate in Multiple Dosages in Modifying Infant Trauma Effects |
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