Colorimetric Determination of Two Nonsteroidal Anti-inflammatory Drugs Using P-Dimethylaminocinnamaldehyde
A colorimetric method for the quantitative determination of diclofenac sodium and mefenamic acid in pure form and in pharmaceutical preparations was developed. It was based on the inter-action of the secondary aromatic amine with p-dimethyl-aminocinnamaldhyde in acidified absolute methanol medium to...
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| Veröffentlicht in: | Analytical letters 1997-07, Vol.30 (10), p.1881-1896 |
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| container_end_page | 1896 |
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| container_issue | 10 |
| container_start_page | 1881 |
| container_title | Analytical letters |
| container_volume | 30 |
| creator | El Sherif, Zeinab A. Walash, M. I. El-Tarras, M. F. Osman, Afaf O. |
| description | A colorimetric method for the quantitative determination of diclofenac sodium and mefenamic acid in pure form and in pharmaceutical preparations was developed. It was based on the inter-action of the secondary aromatic amine with p-dimethyl-aminocinnamaldhyde in acidified absolute methanol medium to form very stable red [λ
max
at 538 nm in case of diclofenac sodium] or blue [λ
max
at 665 nm in case of mefenamic acid] products. Beer's law was obeyed over the ranges 10-80 μg ml
−1
and 1-8 μg ml
−1
for diclofenac sodium and mefenamic acid, respectively. The reactants were heated on a boiling water bath for 6 and 5 mins for each drug, respectively. Optimization of the different experimental conditions were studied. The mean percentage recoveries were found to be 100.73 ± 0.87% & 100.73 ± 0.44%, respectively. The method was applied successfully for the determination of some pharmaceutical formulations.
The validity of the suggested procedure was assessed by applying the standard addition technique. |
| doi_str_mv | 10.1080/00032719708001705 |
| format | Article |
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max
at 538 nm in case of diclofenac sodium] or blue [λ
max
at 665 nm in case of mefenamic acid] products. Beer's law was obeyed over the ranges 10-80 μg ml
−1
and 1-8 μg ml
−1
for diclofenac sodium and mefenamic acid, respectively. The reactants were heated on a boiling water bath for 6 and 5 mins for each drug, respectively. Optimization of the different experimental conditions were studied. The mean percentage recoveries were found to be 100.73 ± 0.87% & 100.73 ± 0.44%, respectively. The method was applied successfully for the determination of some pharmaceutical formulations.
The validity of the suggested procedure was assessed by applying the standard addition technique.</description><identifier>ISSN: 0003-2719</identifier><identifier>EISSN: 1532-236X</identifier><identifier>DOI: 10.1080/00032719708001705</identifier><identifier>CODEN: ANALBP</identifier><language>eng</language><publisher>Philadelphia, PA: Taylor & Francis Group</publisher><subject>Analysis ; Biological and medical sciences ; Colorimetric ; Diclofenac Sodium ; General pharmacology ; Medical sciences ; Mefenamic Acid ; Non steroidal Anti-inflammatory Drugs ; P-dimethylaminocinnam-aldhyde ; Pharmacology. Drug treatments</subject><ispartof>Analytical letters, 1997-07, Vol.30 (10), p.1881-1896</ispartof><rights>Copyright Taylor & Francis Group, LLC 1997</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-d02108d36969c7d1b00aef6aea4fdbd39d275b8f81064931d12ccfbc0871e5c23</citedby><cites>FETCH-LOGICAL-c439t-d02108d36969c7d1b00aef6aea4fdbd39d275b8f81064931d12ccfbc0871e5c23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/00032719708001705$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/00032719708001705$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,59620,60409</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2780058$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>El Sherif, Zeinab A.</creatorcontrib><creatorcontrib>Walash, M. I.</creatorcontrib><creatorcontrib>El-Tarras, M. F.</creatorcontrib><creatorcontrib>Osman, Afaf O.</creatorcontrib><title>Colorimetric Determination of Two Nonsteroidal Anti-inflammatory Drugs Using P-Dimethylaminocinnamaldehyde</title><title>Analytical letters</title><description>A colorimetric method for the quantitative determination of diclofenac sodium and mefenamic acid in pure form and in pharmaceutical preparations was developed. It was based on the inter-action of the secondary aromatic amine with p-dimethyl-aminocinnamaldhyde in acidified absolute methanol medium to form very stable red [λ
max
at 538 nm in case of diclofenac sodium] or blue [λ
max
at 665 nm in case of mefenamic acid] products. Beer's law was obeyed over the ranges 10-80 μg ml
−1
and 1-8 μg ml
−1
for diclofenac sodium and mefenamic acid, respectively. The reactants were heated on a boiling water bath for 6 and 5 mins for each drug, respectively. Optimization of the different experimental conditions were studied. The mean percentage recoveries were found to be 100.73 ± 0.87% & 100.73 ± 0.44%, respectively. The method was applied successfully for the determination of some pharmaceutical formulations.
The validity of the suggested procedure was assessed by applying the standard addition technique.</description><subject>Analysis</subject><subject>Biological and medical sciences</subject><subject>Colorimetric</subject><subject>Diclofenac Sodium</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>Mefenamic Acid</subject><subject>Non steroidal Anti-inflammatory Drugs</subject><subject>P-dimethylaminocinnam-aldhyde</subject><subject>Pharmacology. Drug treatments</subject><issn>0003-2719</issn><issn>1532-236X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNqFkEtLAzEYRYMoWKs_wF0Wbkfz6ExmwE1pfYGoixbcDZk82pSZpCSROv_eDFU3RVyF5Dvnku8CcInRNUYlukEIUcJwxdIFYYbyIzDCOSUZocX7MRgN82wATsFZCJvEkJLgEdjMXOu86VT0RsC5isp3xvJonIVOw8XOwRdnQ3p2RvIWTm00mbG65V3Ho_M9nPuPVYDLYOwKvmXzIWrdp7GxThhrecdbqda9VOfgRPM2qIvvcwyW93eL2WP2_PrwNJs-Z2JCq5hJRNJGkhZVUQkmcYMQV7rgik-0bCStJGF5U-oSo2JSUSwxEUI3ApUMq1wQOgZ4nyu8C8ErXW_Tgtz3NUb1UFZ9UFZyrvbOlgfBW-25FSb8ioQlMC8TxvZYasD5ju-cb2UdeZ86_HEOwuv4GZN5-69J__7fF40ukP0</recordid><startdate>199707</startdate><enddate>199707</enddate><creator>El Sherif, Zeinab A.</creator><creator>Walash, M. I.</creator><creator>El-Tarras, M. F.</creator><creator>Osman, Afaf O.</creator><general>Taylor & Francis Group</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>199707</creationdate><title>Colorimetric Determination of Two Nonsteroidal Anti-inflammatory Drugs Using P-Dimethylaminocinnamaldehyde</title><author>El Sherif, Zeinab A. ; Walash, M. I. ; El-Tarras, M. F. ; Osman, Afaf O.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-d02108d36969c7d1b00aef6aea4fdbd39d275b8f81064931d12ccfbc0871e5c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Analysis</topic><topic>Biological and medical sciences</topic><topic>Colorimetric</topic><topic>Diclofenac Sodium</topic><topic>General pharmacology</topic><topic>Medical sciences</topic><topic>Mefenamic Acid</topic><topic>Non steroidal Anti-inflammatory Drugs</topic><topic>P-dimethylaminocinnam-aldhyde</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>El Sherif, Zeinab A.</creatorcontrib><creatorcontrib>Walash, M. I.</creatorcontrib><creatorcontrib>El-Tarras, M. F.</creatorcontrib><creatorcontrib>Osman, Afaf O.</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><jtitle>Analytical letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>El Sherif, Zeinab A.</au><au>Walash, M. I.</au><au>El-Tarras, M. F.</au><au>Osman, Afaf O.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Colorimetric Determination of Two Nonsteroidal Anti-inflammatory Drugs Using P-Dimethylaminocinnamaldehyde</atitle><jtitle>Analytical letters</jtitle><date>1997-07</date><risdate>1997</risdate><volume>30</volume><issue>10</issue><spage>1881</spage><epage>1896</epage><pages>1881-1896</pages><issn>0003-2719</issn><eissn>1532-236X</eissn><coden>ANALBP</coden><abstract>A colorimetric method for the quantitative determination of diclofenac sodium and mefenamic acid in pure form and in pharmaceutical preparations was developed. It was based on the inter-action of the secondary aromatic amine with p-dimethyl-aminocinnamaldhyde in acidified absolute methanol medium to form very stable red [λ
max
at 538 nm in case of diclofenac sodium] or blue [λ
max
at 665 nm in case of mefenamic acid] products. Beer's law was obeyed over the ranges 10-80 μg ml
−1
and 1-8 μg ml
−1
for diclofenac sodium and mefenamic acid, respectively. The reactants were heated on a boiling water bath for 6 and 5 mins for each drug, respectively. Optimization of the different experimental conditions were studied. The mean percentage recoveries were found to be 100.73 ± 0.87% & 100.73 ± 0.44%, respectively. The method was applied successfully for the determination of some pharmaceutical formulations.
The validity of the suggested procedure was assessed by applying the standard addition technique.</abstract><cop>Philadelphia, PA</cop><pub>Taylor & Francis Group</pub><doi>10.1080/00032719708001705</doi><tpages>16</tpages></addata></record> |
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| ispartof | Analytical letters, 1997-07, Vol.30 (10), p.1881-1896 |
| issn | 0003-2719 1532-236X |
| language | eng |
| recordid | cdi_crossref_primary_10_1080_00032719708001705 |
| source | Taylor & Francis |
| subjects | Analysis Biological and medical sciences Colorimetric Diclofenac Sodium General pharmacology Medical sciences Mefenamic Acid Non steroidal Anti-inflammatory Drugs P-dimethylaminocinnam-aldhyde Pharmacology. Drug treatments |
| title | Colorimetric Determination of Two Nonsteroidal Anti-inflammatory Drugs Using P-Dimethylaminocinnamaldehyde |
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