Distribution of vanilloid receptors in the rat laryngeal innervation
Objective Capsaicin is known to selectively activate nociceptic sensory neurons through vanilloid receptors. In this study we investigated the distribution of vanilloid receptor subtype 1 (VR1) and vanilloid receptor-like protein 1 (VRL-1) in the rat larynx. Material and Methods The distributions of...
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| Veröffentlicht in: | Acta oto-laryngologica 2004-05, Vol.124 (4), p.515-519 |
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| container_title | Acta oto-laryngologica |
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| creator | Koike, Shinobu Uno, Toshiyuki Bamba, Hitoshi Shibata, Toshiaki Okano, Hiroyuki Hisa, Yasuo |
| description | Objective
Capsaicin is known to selectively activate nociceptic sensory neurons through vanilloid receptors. In this study we investigated the distribution of vanilloid receptor subtype 1 (VR1) and vanilloid receptor-like protein 1 (VRL-1) in the rat larynx.
Material and Methods
The distributions of VR1 and VRL-1 were determined immunohistochemically. The colocalization of vanilloid receptors with common choline acetyltransferase (cChAT), vasoactive intestinal polypeptide (VIP), substance P (SP) and neuronal nitric oxide synthase (nNOS) was also studied using an immunohistochemical double-labeling technique.
Results
VRL-1-positive fibers were detected in the laryngeal epithelium and lamina propria. VR1-positive nerve fibers were seen in the lamina propria but not in the mucosal epithelium. VR1- and VRL-1-positive cells were distributed in the intralaryngeal ganglia and colocalization of capsaicin receptors with VIP, nNOS and cChAT was seen.
Conclusion
These findings suggest that these capsaicin receptors participate in the parasympathetic innervation as well as in nociception of the rat larynx. |
| doi_str_mv | 10.1080/00016480310000674 |
| format | Article |
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Capsaicin is known to selectively activate nociceptic sensory neurons through vanilloid receptors. In this study we investigated the distribution of vanilloid receptor subtype 1 (VR1) and vanilloid receptor-like protein 1 (VRL-1) in the rat larynx.
Material and Methods
The distributions of VR1 and VRL-1 were determined immunohistochemically. The colocalization of vanilloid receptors with common choline acetyltransferase (cChAT), vasoactive intestinal polypeptide (VIP), substance P (SP) and neuronal nitric oxide synthase (nNOS) was also studied using an immunohistochemical double-labeling technique.
Results
VRL-1-positive fibers were detected in the laryngeal epithelium and lamina propria. VR1-positive nerve fibers were seen in the lamina propria but not in the mucosal epithelium. VR1- and VRL-1-positive cells were distributed in the intralaryngeal ganglia and colocalization of capsaicin receptors with VIP, nNOS and cChAT was seen.
Conclusion
These findings suggest that these capsaicin receptors participate in the parasympathetic innervation as well as in nociception of the rat larynx.</description><identifier>ISSN: 0001-6489</identifier><identifier>EISSN: 1651-2251</identifier><identifier>DOI: 10.1080/00016480310000674</identifier><identifier>PMID: 15224886</identifier><identifier>CODEN: AOLAAJ</identifier><language>eng</language><publisher>Stockholm: Informa UK Ltd</publisher><subject>Animals ; Biological and medical sciences ; Capsaicin - metabolism ; common choline acetyltransferase ; Immunohistochemistry ; intralaryngeal ganglion ; Ion Channels ; Laryngeal Mucosa - innervation ; Laryngeal Nerves - metabolism ; Medical sciences ; Nerve Fibers - metabolism ; neuronal nitric oxide synthase ; nociceptor ; Nociceptors - metabolism ; Otorhinolaryngology. Stomatology ; Rats ; Rats, Sprague-Dawley ; Receptors, Drug - metabolism ; substance P ; TRPV Cation Channels ; vanilloid receptor like-protein 1 ; vanilloid receptor subtype 1 ; vasoactive intestinal polypeptide</subject><ispartof>Acta oto-laryngologica, 2004-05, Vol.124 (4), p.515-519</ispartof><rights>2004 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2004</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c529t-bc3205e41755569936889bf41053b5b4d41c9533c87d4369ea6a93b602dba36b3</citedby><cites>FETCH-LOGICAL-c529t-bc3205e41755569936889bf41053b5b4d41c9533c87d4369ea6a93b602dba36b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/00016480310000674$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/00016480310000674$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>309,310,314,778,782,787,788,23913,23914,25123,27907,27908,59628,59734,60417,60523,61202,61237,61383,61418</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15773722$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15224886$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koike, Shinobu</creatorcontrib><creatorcontrib>Uno, Toshiyuki</creatorcontrib><creatorcontrib>Bamba, Hitoshi</creatorcontrib><creatorcontrib>Shibata, Toshiaki</creatorcontrib><creatorcontrib>Okano, Hiroyuki</creatorcontrib><creatorcontrib>Hisa, Yasuo</creatorcontrib><title>Distribution of vanilloid receptors in the rat laryngeal innervation</title><title>Acta oto-laryngologica</title><addtitle>Acta Otolaryngol</addtitle><description>Objective
Capsaicin is known to selectively activate nociceptic sensory neurons through vanilloid receptors. In this study we investigated the distribution of vanilloid receptor subtype 1 (VR1) and vanilloid receptor-like protein 1 (VRL-1) in the rat larynx.
Material and Methods
The distributions of VR1 and VRL-1 were determined immunohistochemically. The colocalization of vanilloid receptors with common choline acetyltransferase (cChAT), vasoactive intestinal polypeptide (VIP), substance P (SP) and neuronal nitric oxide synthase (nNOS) was also studied using an immunohistochemical double-labeling technique.
Results
VRL-1-positive fibers were detected in the laryngeal epithelium and lamina propria. VR1-positive nerve fibers were seen in the lamina propria but not in the mucosal epithelium. VR1- and VRL-1-positive cells were distributed in the intralaryngeal ganglia and colocalization of capsaicin receptors with VIP, nNOS and cChAT was seen.
Conclusion
These findings suggest that these capsaicin receptors participate in the parasympathetic innervation as well as in nociception of the rat larynx.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Capsaicin - metabolism</subject><subject>common choline acetyltransferase</subject><subject>Immunohistochemistry</subject><subject>intralaryngeal ganglion</subject><subject>Ion Channels</subject><subject>Laryngeal Mucosa - innervation</subject><subject>Laryngeal Nerves - metabolism</subject><subject>Medical sciences</subject><subject>Nerve Fibers - metabolism</subject><subject>neuronal nitric oxide synthase</subject><subject>nociceptor</subject><subject>Nociceptors - metabolism</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, Drug - metabolism</subject><subject>substance P</subject><subject>TRPV Cation Channels</subject><subject>vanilloid receptor like-protein 1</subject><subject>vanilloid receptor subtype 1</subject><subject>vasoactive intestinal polypeptide</subject><issn>0001-6489</issn><issn>1651-2251</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1PGzEQhq2KqgTaH8AF7YXetvX32oIL4quVIvXSnle210uMHDvY3qD8-zpKKkBI9OSx53lnPO8AcILgNwQF_A4hRJwKSFCNIO_oBzBDnKEWY4YOwGybbysgD8FRzg_bqxTsEzhEDGMqBJ-B62uXS3J6Ki6GJo7NWgXnfXRDk6yxqxJTblxoysI2SZXGq7QJ91b5-hhsWqut7jP4OCqf7Zf9eQz-3N78vvrRzn_d_by6nLeGYVlabQiGzFLUMca4lIQLIfVIEWREM00HioxkhBjRDZRwaRVXkmgO8aAV4Zocg6-7uqsUHyebS7902VjvVbBxyj3nnAlO6H9BDGVtQLsKoh1oUsw52bFfJbesM_YI9luP-zceV83pvvikl3Z4VuxNrcDZHlDZKD8mFYzLL7iuIx3GlbvYcS6MMS3VU0x-6Iva-Jj-ich7_zh_JV_UrZSFUcn2D3FKoW7inSn-Arxkp2c</recordid><startdate>20040501</startdate><enddate>20040501</enddate><creator>Koike, Shinobu</creator><creator>Uno, Toshiyuki</creator><creator>Bamba, Hitoshi</creator><creator>Shibata, Toshiaki</creator><creator>Okano, Hiroyuki</creator><creator>Hisa, Yasuo</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Taylor and Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>20040501</creationdate><title>Distribution of vanilloid receptors in the rat laryngeal innervation</title><author>Koike, Shinobu ; Uno, Toshiyuki ; Bamba, Hitoshi ; Shibata, Toshiaki ; Okano, Hiroyuki ; Hisa, Yasuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c529t-bc3205e41755569936889bf41053b5b4d41c9533c87d4369ea6a93b602dba36b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Capsaicin - metabolism</topic><topic>common choline acetyltransferase</topic><topic>Immunohistochemistry</topic><topic>intralaryngeal ganglion</topic><topic>Ion Channels</topic><topic>Laryngeal Mucosa - innervation</topic><topic>Laryngeal Nerves - metabolism</topic><topic>Medical sciences</topic><topic>Nerve Fibers - metabolism</topic><topic>neuronal nitric oxide synthase</topic><topic>nociceptor</topic><topic>Nociceptors - metabolism</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, Drug - metabolism</topic><topic>substance P</topic><topic>TRPV Cation Channels</topic><topic>vanilloid receptor like-protein 1</topic><topic>vanilloid receptor subtype 1</topic><topic>vasoactive intestinal polypeptide</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koike, Shinobu</creatorcontrib><creatorcontrib>Uno, Toshiyuki</creatorcontrib><creatorcontrib>Bamba, Hitoshi</creatorcontrib><creatorcontrib>Shibata, Toshiaki</creatorcontrib><creatorcontrib>Okano, Hiroyuki</creatorcontrib><creatorcontrib>Hisa, Yasuo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>Acta oto-laryngologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koike, Shinobu</au><au>Uno, Toshiyuki</au><au>Bamba, Hitoshi</au><au>Shibata, Toshiaki</au><au>Okano, Hiroyuki</au><au>Hisa, Yasuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distribution of vanilloid receptors in the rat laryngeal innervation</atitle><jtitle>Acta oto-laryngologica</jtitle><addtitle>Acta Otolaryngol</addtitle><date>2004-05-01</date><risdate>2004</risdate><volume>124</volume><issue>4</issue><spage>515</spage><epage>519</epage><pages>515-519</pages><issn>0001-6489</issn><eissn>1651-2251</eissn><coden>AOLAAJ</coden><abstract>Objective
Capsaicin is known to selectively activate nociceptic sensory neurons through vanilloid receptors. In this study we investigated the distribution of vanilloid receptor subtype 1 (VR1) and vanilloid receptor-like protein 1 (VRL-1) in the rat larynx.
Material and Methods
The distributions of VR1 and VRL-1 were determined immunohistochemically. The colocalization of vanilloid receptors with common choline acetyltransferase (cChAT), vasoactive intestinal polypeptide (VIP), substance P (SP) and neuronal nitric oxide synthase (nNOS) was also studied using an immunohistochemical double-labeling technique.
Results
VRL-1-positive fibers were detected in the laryngeal epithelium and lamina propria. VR1-positive nerve fibers were seen in the lamina propria but not in the mucosal epithelium. VR1- and VRL-1-positive cells were distributed in the intralaryngeal ganglia and colocalization of capsaicin receptors with VIP, nNOS and cChAT was seen.
Conclusion
These findings suggest that these capsaicin receptors participate in the parasympathetic innervation as well as in nociception of the rat larynx.</abstract><cop>Stockholm</cop><pub>Informa UK Ltd</pub><pmid>15224886</pmid><doi>10.1080/00016480310000674</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Taylor & Francis:Master (3349 titles); Taylor & Francis Medical Library - CRKN |
| subjects | Animals Biological and medical sciences Capsaicin - metabolism common choline acetyltransferase Immunohistochemistry intralaryngeal ganglion Ion Channels Laryngeal Mucosa - innervation Laryngeal Nerves - metabolism Medical sciences Nerve Fibers - metabolism neuronal nitric oxide synthase nociceptor Nociceptors - metabolism Otorhinolaryngology. Stomatology Rats Rats, Sprague-Dawley Receptors, Drug - metabolism substance P TRPV Cation Channels vanilloid receptor like-protein 1 vanilloid receptor subtype 1 vasoactive intestinal polypeptide |
| title | Distribution of vanilloid receptors in the rat laryngeal innervation |
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