Drug exposure and psoriasis vulgaris : Case-control and case-crossover studies
Intake of drugs is considered a risk factor for psoriasis. The aim of this study was to investigate the association between drugs and psoriasis. A case-control study including 110 patients who were hospitalized for extensive psoriasis was performed. A control group (n = 515) was defined as patients...
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Veröffentlicht in: | Acta dermato-venereologica 2005-01, Vol.85 (4), p.299-303 |
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creator | COHEN, Arnon D BONNEH, Dan Y REUVENI, Haim VARDY, Daniel A NAGGAN, Lechaim HALEVY, Sima |
description | Intake of drugs is considered a risk factor for psoriasis. The aim of this study was to investigate the association between drugs and psoriasis. A case-control study including 110 patients who were hospitalized for extensive psoriasis was performed. A control group (n = 515) was defined as patients who had undergone elective surgery. A case-crossover study included 98 patients with psoriasis. Exposure to drugs was assessed during a hazard period (3 months before hospitalization) and compared to a control period in the patient's past. Data on drug sales were extracted by data mining techniques. Multivariate analyses were performed by logistic regression and conditional logistic regression. In the case-control study, psoriasis was associated with benzodiazepines (OR 6.9), organic nitrates (OR 5.0), angiotensin-converting enzyme (ACE) inhibitors (OR 4.0) and non-steroidal anti-inflammatory drugs (NSAIDs) (OR 3.7). In the case-crossover study, psoriasis was associated with ACE inhibitors (OR 9.9), beta-blockers (OR 9.9), dipyrone (OR 4.9) and NSAIDs (OR 2.1). Extensive psoriasis may be associated with intake of ACE inhibitors, NSAIDs or beta-blockers. |
doi_str_mv | 10.1080/00015550510032823 |
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The aim of this study was to investigate the association between drugs and psoriasis. A case-control study including 110 patients who were hospitalized for extensive psoriasis was performed. A control group (n = 515) was defined as patients who had undergone elective surgery. A case-crossover study included 98 patients with psoriasis. Exposure to drugs was assessed during a hazard period (3 months before hospitalization) and compared to a control period in the patient's past. Data on drug sales were extracted by data mining techniques. Multivariate analyses were performed by logistic regression and conditional logistic regression. In the case-control study, psoriasis was associated with benzodiazepines (OR 6.9), organic nitrates (OR 5.0), angiotensin-converting enzyme (ACE) inhibitors (OR 4.0) and non-steroidal anti-inflammatory drugs (NSAIDs) (OR 3.7). In the case-crossover study, psoriasis was associated with ACE inhibitors (OR 9.9), beta-blockers (OR 9.9), dipyrone (OR 4.9) and NSAIDs (OR 2.1). Extensive psoriasis may be associated with intake of ACE inhibitors, NSAIDs or beta-blockers.</description><identifier>ISSN: 0001-5555</identifier><identifier>EISSN: 1651-2057</identifier><identifier>DOI: 10.1080/00015550510032823</identifier><identifier>PMID: 16191849</identifier><identifier>CODEN: ADVEA4</identifier><language>eng</language><publisher>Uppsala: Acta dermato-venereologica</publisher><subject>Adrenergic beta-Antagonists - adverse effects ; Angiotensin-Converting Enzyme Inhibitors - adverse effects ; Anti-Inflammatory Agents, Non-Steroidal - adverse effects ; Biological and medical sciences ; Case-Control Studies ; Cross-Over Studies ; Dermatology ; Drug Prescriptions - statistics & numerical data ; Female ; Humans ; Italy - epidemiology ; Logistic Models ; Male ; Medical sciences ; Middle Aged ; Psoriasis - chemically induced ; Psoriasis - epidemiology ; Psoriasis - pathology ; Psoriasis. Parapsoriasis. 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The aim of this study was to investigate the association between drugs and psoriasis. A case-control study including 110 patients who were hospitalized for extensive psoriasis was performed. A control group (n = 515) was defined as patients who had undergone elective surgery. A case-crossover study included 98 patients with psoriasis. Exposure to drugs was assessed during a hazard period (3 months before hospitalization) and compared to a control period in the patient's past. Data on drug sales were extracted by data mining techniques. Multivariate analyses were performed by logistic regression and conditional logistic regression. In the case-control study, psoriasis was associated with benzodiazepines (OR 6.9), organic nitrates (OR 5.0), angiotensin-converting enzyme (ACE) inhibitors (OR 4.0) and non-steroidal anti-inflammatory drugs (NSAIDs) (OR 3.7). In the case-crossover study, psoriasis was associated with ACE inhibitors (OR 9.9), beta-blockers (OR 9.9), dipyrone (OR 4.9) and NSAIDs (OR 2.1). Extensive psoriasis may be associated with intake of ACE inhibitors, NSAIDs or beta-blockers.</description><subject>Adrenergic beta-Antagonists - adverse effects</subject><subject>Angiotensin-Converting Enzyme Inhibitors - adverse effects</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - adverse effects</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Cross-Over Studies</subject><subject>Dermatology</subject><subject>Drug Prescriptions - statistics & numerical data</subject><subject>Female</subject><subject>Humans</subject><subject>Italy - epidemiology</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Psoriasis - chemically induced</subject><subject>Psoriasis - epidemiology</subject><subject>Psoriasis - pathology</subject><subject>Psoriasis. Parapsoriasis. Lichen</subject><subject>Severity of Illness Index</subject><issn>0001-5555</issn><issn>1651-2057</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkMlOwzAQhi0EoqXwAFxQLhwDHi-Jww21bFIFFzhHY8eugtIm8jQVvD3pIoHEabbvH838jF0CvwFu-C3nHLTWXAPnUhghj9gYMg2p4Do_ZuPtPB0APWJnRJ9DKTSYUzaCDAowqhiz11nsF4n_6lrqo09wVSUdtbFGqinZ9M0C45DcJVMkn7p2tY5ts6PcrhFbonbjY0Lrvqo9nbOTgA35i0OcsI_Hh_fpczp_e3qZ3s9TJ3OxTqUubK4cSgeykiEgBxTSWoPee1Q2c1IqHD4pfJFbFXJljDM2oKgqFayVEwb7vbsLog9lF-slxu8SeLn1pvznzaC52mu63i599as4mDEA1wcAyWETIq5cTX-4wnCTZfIHwrNs2w</recordid><startdate>20050101</startdate><enddate>20050101</enddate><creator>COHEN, Arnon D</creator><creator>BONNEH, Dan Y</creator><creator>REUVENI, Haim</creator><creator>VARDY, Daniel A</creator><creator>NAGGAN, Lechaim</creator><creator>HALEVY, Sima</creator><general>Acta dermato-venereologica</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20050101</creationdate><title>Drug exposure and psoriasis vulgaris : Case-control and case-crossover studies</title><author>COHEN, Arnon D ; BONNEH, Dan Y ; REUVENI, Haim ; VARDY, Daniel A ; NAGGAN, Lechaim ; HALEVY, Sima</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-359b74ca3c13d3ffa01a23bb8aeeea4b6c334a6519e97b4f7488c8bfa2dd4fbb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adrenergic beta-Antagonists - adverse effects</topic><topic>Angiotensin-Converting Enzyme Inhibitors - adverse effects</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - adverse effects</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Cross-Over Studies</topic><topic>Dermatology</topic><topic>Drug Prescriptions - statistics & numerical data</topic><topic>Female</topic><topic>Humans</topic><topic>Italy - epidemiology</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Psoriasis - chemically induced</topic><topic>Psoriasis - epidemiology</topic><topic>Psoriasis - pathology</topic><topic>Psoriasis. Parapsoriasis. Lichen</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>COHEN, Arnon D</creatorcontrib><creatorcontrib>BONNEH, Dan Y</creatorcontrib><creatorcontrib>REUVENI, Haim</creatorcontrib><creatorcontrib>VARDY, Daniel A</creatorcontrib><creatorcontrib>NAGGAN, Lechaim</creatorcontrib><creatorcontrib>HALEVY, Sima</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Acta dermato-venereologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>COHEN, Arnon D</au><au>BONNEH, Dan Y</au><au>REUVENI, Haim</au><au>VARDY, Daniel A</au><au>NAGGAN, Lechaim</au><au>HALEVY, Sima</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Drug exposure and psoriasis vulgaris : Case-control and case-crossover studies</atitle><jtitle>Acta dermato-venereologica</jtitle><addtitle>Acta Derm Venereol</addtitle><date>2005-01-01</date><risdate>2005</risdate><volume>85</volume><issue>4</issue><spage>299</spage><epage>303</epage><pages>299-303</pages><issn>0001-5555</issn><eissn>1651-2057</eissn><coden>ADVEA4</coden><abstract>Intake of drugs is considered a risk factor for psoriasis. The aim of this study was to investigate the association between drugs and psoriasis. A case-control study including 110 patients who were hospitalized for extensive psoriasis was performed. A control group (n = 515) was defined as patients who had undergone elective surgery. A case-crossover study included 98 patients with psoriasis. Exposure to drugs was assessed during a hazard period (3 months before hospitalization) and compared to a control period in the patient's past. Data on drug sales were extracted by data mining techniques. Multivariate analyses were performed by logistic regression and conditional logistic regression. In the case-control study, psoriasis was associated with benzodiazepines (OR 6.9), organic nitrates (OR 5.0), angiotensin-converting enzyme (ACE) inhibitors (OR 4.0) and non-steroidal anti-inflammatory drugs (NSAIDs) (OR 3.7). In the case-crossover study, psoriasis was associated with ACE inhibitors (OR 9.9), beta-blockers (OR 9.9), dipyrone (OR 4.9) and NSAIDs (OR 2.1). Extensive psoriasis may be associated with intake of ACE inhibitors, NSAIDs or beta-blockers.</abstract><cop>Uppsala</cop><pub>Acta dermato-venereologica</pub><pmid>16191849</pmid><doi>10.1080/00015550510032823</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adrenergic beta-Antagonists - adverse effects Angiotensin-Converting Enzyme Inhibitors - adverse effects Anti-Inflammatory Agents, Non-Steroidal - adverse effects Biological and medical sciences Case-Control Studies Cross-Over Studies Dermatology Drug Prescriptions - statistics & numerical data Female Humans Italy - epidemiology Logistic Models Male Medical sciences Middle Aged Psoriasis - chemically induced Psoriasis - epidemiology Psoriasis - pathology Psoriasis. Parapsoriasis. Lichen Severity of Illness Index |
title | Drug exposure and psoriasis vulgaris : Case-control and case-crossover studies |
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