Drug exposure and psoriasis vulgaris : Case-control and case-crossover studies

Intake of drugs is considered a risk factor for psoriasis. The aim of this study was to investigate the association between drugs and psoriasis. A case-control study including 110 patients who were hospitalized for extensive psoriasis was performed. A control group (n = 515) was defined as patients...

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Veröffentlicht in:Acta dermato-venereologica 2005-01, Vol.85 (4), p.299-303
Hauptverfasser: COHEN, Arnon D, BONNEH, Dan Y, REUVENI, Haim, VARDY, Daniel A, NAGGAN, Lechaim, HALEVY, Sima
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container_issue 4
container_start_page 299
container_title Acta dermato-venereologica
container_volume 85
creator COHEN, Arnon D
BONNEH, Dan Y
REUVENI, Haim
VARDY, Daniel A
NAGGAN, Lechaim
HALEVY, Sima
description Intake of drugs is considered a risk factor for psoriasis. The aim of this study was to investigate the association between drugs and psoriasis. A case-control study including 110 patients who were hospitalized for extensive psoriasis was performed. A control group (n = 515) was defined as patients who had undergone elective surgery. A case-crossover study included 98 patients with psoriasis. Exposure to drugs was assessed during a hazard period (3 months before hospitalization) and compared to a control period in the patient's past. Data on drug sales were extracted by data mining techniques. Multivariate analyses were performed by logistic regression and conditional logistic regression. In the case-control study, psoriasis was associated with benzodiazepines (OR 6.9), organic nitrates (OR 5.0), angiotensin-converting enzyme (ACE) inhibitors (OR 4.0) and non-steroidal anti-inflammatory drugs (NSAIDs) (OR 3.7). In the case-crossover study, psoriasis was associated with ACE inhibitors (OR 9.9), beta-blockers (OR 9.9), dipyrone (OR 4.9) and NSAIDs (OR 2.1). Extensive psoriasis may be associated with intake of ACE inhibitors, NSAIDs or beta-blockers.
doi_str_mv 10.1080/00015550510032823
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The aim of this study was to investigate the association between drugs and psoriasis. A case-control study including 110 patients who were hospitalized for extensive psoriasis was performed. A control group (n = 515) was defined as patients who had undergone elective surgery. A case-crossover study included 98 patients with psoriasis. Exposure to drugs was assessed during a hazard period (3 months before hospitalization) and compared to a control period in the patient's past. Data on drug sales were extracted by data mining techniques. Multivariate analyses were performed by logistic regression and conditional logistic regression. In the case-control study, psoriasis was associated with benzodiazepines (OR 6.9), organic nitrates (OR 5.0), angiotensin-converting enzyme (ACE) inhibitors (OR 4.0) and non-steroidal anti-inflammatory drugs (NSAIDs) (OR 3.7). In the case-crossover study, psoriasis was associated with ACE inhibitors (OR 9.9), beta-blockers (OR 9.9), dipyrone (OR 4.9) and NSAIDs (OR 2.1). 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The aim of this study was to investigate the association between drugs and psoriasis. A case-control study including 110 patients who were hospitalized for extensive psoriasis was performed. A control group (n = 515) was defined as patients who had undergone elective surgery. A case-crossover study included 98 patients with psoriasis. Exposure to drugs was assessed during a hazard period (3 months before hospitalization) and compared to a control period in the patient's past. Data on drug sales were extracted by data mining techniques. Multivariate analyses were performed by logistic regression and conditional logistic regression. In the case-control study, psoriasis was associated with benzodiazepines (OR 6.9), organic nitrates (OR 5.0), angiotensin-converting enzyme (ACE) inhibitors (OR 4.0) and non-steroidal anti-inflammatory drugs (NSAIDs) (OR 3.7). In the case-crossover study, psoriasis was associated with ACE inhibitors (OR 9.9), beta-blockers (OR 9.9), dipyrone (OR 4.9) and NSAIDs (OR 2.1). 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Lichen</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>COHEN, Arnon D</creatorcontrib><creatorcontrib>BONNEH, Dan Y</creatorcontrib><creatorcontrib>REUVENI, Haim</creatorcontrib><creatorcontrib>VARDY, Daniel A</creatorcontrib><creatorcontrib>NAGGAN, Lechaim</creatorcontrib><creatorcontrib>HALEVY, Sima</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Acta dermato-venereologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>COHEN, Arnon D</au><au>BONNEH, Dan Y</au><au>REUVENI, Haim</au><au>VARDY, Daniel A</au><au>NAGGAN, Lechaim</au><au>HALEVY, Sima</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Drug exposure and psoriasis vulgaris : Case-control and case-crossover studies</atitle><jtitle>Acta dermato-venereologica</jtitle><addtitle>Acta Derm Venereol</addtitle><date>2005-01-01</date><risdate>2005</risdate><volume>85</volume><issue>4</issue><spage>299</spage><epage>303</epage><pages>299-303</pages><issn>0001-5555</issn><eissn>1651-2057</eissn><coden>ADVEA4</coden><abstract>Intake of drugs is considered a risk factor for psoriasis. 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subjects Adrenergic beta-Antagonists - adverse effects
Angiotensin-Converting Enzyme Inhibitors - adverse effects
Anti-Inflammatory Agents, Non-Steroidal - adverse effects
Biological and medical sciences
Case-Control Studies
Cross-Over Studies
Dermatology
Drug Prescriptions - statistics & numerical data
Female
Humans
Italy - epidemiology
Logistic Models
Male
Medical sciences
Middle Aged
Psoriasis - chemically induced
Psoriasis - epidemiology
Psoriasis - pathology
Psoriasis. Parapsoriasis. Lichen
Severity of Illness Index
title Drug exposure and psoriasis vulgaris : Case-control and case-crossover studies
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