Experimental cadmium poisoning in sheep
Pathomorphological investigations of internal organs were made in sheep given sublethal doses of cadmium. Early histological damages in kidneys were established by renal biopsy in some experimental animals. The main histological changes were characterized by granular degeneration in proximal tubules...
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| Veröffentlicht in: | Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2003-11, Vol.55 (4), p.309-314 |
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| container_issue | 4 |
| container_start_page | 309 |
| container_title | Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie |
| container_volume | 55 |
| creator | Stoev, Stoycho D. Grozeva, N. Simeonov, R. Borisov, I. Hubenov, H. Nikolov, Y. Tsaneva, M. Lazarova, S. |
| description | Pathomorphological investigations of internal organs were made in sheep given sublethal doses of cadmium. Early histological damages in kidneys were established by renal biopsy in some experimental animals. The main histological changes were characterized by granular degeneration in proximal tubules and glomerular endothelial proliferation in kidneys, granular degeneration in hepatocytes, pericapillary oedema and activation of capillary endothelium and Kupffer cells in liver, oedematous and degenerative changes in cerebrum and in the region of Purkinje cells of cerebellum, hyperplasia and proliferation of alveolar epithelium and perivascular or peribronchial mononuclear cell infiltration in lung, and degenerative changes in the medulla and zona glomerulosa of adrenal glands. |
| doi_str_mv | 10.1078/0940-2993-00333 |
| format | Article |
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Early histological damages in kidneys were established by renal biopsy in some experimental animals. The main histological changes were characterized by granular degeneration in proximal tubules and glomerular endothelial proliferation in kidneys, granular degeneration in hepatocytes, pericapillary oedema and activation of capillary endothelium and Kupffer cells in liver, oedematous and degenerative changes in cerebrum and in the region of Purkinje cells of cerebellum, hyperplasia and proliferation of alveolar epithelium and perivascular or peribronchial mononuclear cell infiltration in lung, and degenerative changes in the medulla and zona glomerulosa of adrenal glands.</description><identifier>ISSN: 0940-2993</identifier><identifier>EISSN: 1618-1433</identifier><identifier>DOI: 10.1078/0940-2993-00333</identifier><identifier>PMID: 14703778</identifier><language>eng</language><publisher>Jena: Elsevier GmbH</publisher><subject>Adrenal Glands - drug effects ; Adrenal Glands - pathology ; Animals ; Biological and medical sciences ; Cadmium ; Cadmium - toxicity ; Cadmium Poisoning - pathology ; Cerebellum - drug effects ; Cerebellum - pathology ; Chemical and industrial products toxicology. Toxic occupational diseases ; General aspects ; Health hazard ; Hepatocytes - drug effects ; Hepatocytes - pathology ; Intoxication ; Kidney Glomerulus - drug effects ; Kidney Glomerulus - pathology ; Kidney Tubules, Proximal - drug effects ; Kidney Tubules, Proximal - pathology ; Kupffer Cells - drug effects ; Kupffer Cells - pathology ; Liver - drug effects ; Liver - pathology ; Lung - drug effects ; Lung - pathology ; Medical sciences ; Pathomorphology ; Poisoning ; Sheep ; Toxicology</subject><ispartof>Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie, 2003-11, Vol.55 (4), p.309-314</ispartof><rights>2003 Urban & Fischer Verlag</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c373t-e344143d56ea888fc101e8822d43a1f8724624efb80136576d92769d3089869b3</citedby><cites>FETCH-LOGICAL-c373t-e344143d56ea888fc101e8822d43a1f8724624efb80136576d92769d3089869b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1078/0940-2993-00333$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15334135$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14703778$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stoev, Stoycho D.</creatorcontrib><creatorcontrib>Grozeva, N.</creatorcontrib><creatorcontrib>Simeonov, R.</creatorcontrib><creatorcontrib>Borisov, I.</creatorcontrib><creatorcontrib>Hubenov, H.</creatorcontrib><creatorcontrib>Nikolov, Y.</creatorcontrib><creatorcontrib>Tsaneva, M.</creatorcontrib><creatorcontrib>Lazarova, S.</creatorcontrib><title>Experimental cadmium poisoning in sheep</title><title>Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie</title><addtitle>Exp Toxicol Pathol</addtitle><description>Pathomorphological investigations of internal organs were made in sheep given sublethal doses of cadmium. Early histological damages in kidneys were established by renal biopsy in some experimental animals. The main histological changes were characterized by granular degeneration in proximal tubules and glomerular endothelial proliferation in kidneys, granular degeneration in hepatocytes, pericapillary oedema and activation of capillary endothelium and Kupffer cells in liver, oedematous and degenerative changes in cerebrum and in the region of Purkinje cells of cerebellum, hyperplasia and proliferation of alveolar epithelium and perivascular or peribronchial mononuclear cell infiltration in lung, and degenerative changes in the medulla and zona glomerulosa of adrenal glands.</description><subject>Adrenal Glands - drug effects</subject><subject>Adrenal Glands - pathology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cadmium</subject><subject>Cadmium - toxicity</subject><subject>Cadmium Poisoning - pathology</subject><subject>Cerebellum - drug effects</subject><subject>Cerebellum - pathology</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>General aspects</subject><subject>Health hazard</subject><subject>Hepatocytes - drug effects</subject><subject>Hepatocytes - pathology</subject><subject>Intoxication</subject><subject>Kidney Glomerulus - drug effects</subject><subject>Kidney Glomerulus - pathology</subject><subject>Kidney Tubules, Proximal - drug effects</subject><subject>Kidney Tubules, Proximal - pathology</subject><subject>Kupffer Cells - drug effects</subject><subject>Kupffer Cells - pathology</subject><subject>Liver - drug effects</subject><subject>Liver - pathology</subject><subject>Lung - drug effects</subject><subject>Lung - pathology</subject><subject>Medical sciences</subject><subject>Pathomorphology</subject><subject>Poisoning</subject><subject>Sheep</subject><subject>Toxicology</subject><issn>0940-2993</issn><issn>1618-1433</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1j7tOAzEQRS0EIiFQ06FtENUS2-P1o0RReEiRaKC2HHsWjLIP2QmCv2dDIlJRTTHnztxDyCWjt4wqPaVG0JIbAyWlAHBExkwyXTIBcEzGf9sROcv5g1JOTcVOyYgJRUEpPSY3868eU2ywXbtV4V1o4qYp-i7mro3tWxHbIr8j9ufkpHarjBf7OSGv9_OX2WO5eH54mt0tSg8K1iWCEMPzUEl0WuvaM8pQa86DAMdqrbiQXGC91JSBrJQMhitpAlBttDRLmJDp7q5PXc4Ja9sP7Vz6tozarbLdStmtlP1VHhJXu0S_WTYYDvzecQCu94DL3q3q5Fof84GrAASDauDMjsPB7zNistlHbD2GmNCvbejivyV-AJuPbbc</recordid><startdate>20031101</startdate><enddate>20031101</enddate><creator>Stoev, Stoycho D.</creator><creator>Grozeva, N.</creator><creator>Simeonov, R.</creator><creator>Borisov, I.</creator><creator>Hubenov, H.</creator><creator>Nikolov, Y.</creator><creator>Tsaneva, M.</creator><creator>Lazarova, S.</creator><general>Elsevier GmbH</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20031101</creationdate><title>Experimental cadmium poisoning in sheep</title><author>Stoev, Stoycho D. ; Grozeva, N. ; Simeonov, R. ; Borisov, I. ; Hubenov, H. ; Nikolov, Y. ; Tsaneva, M. ; Lazarova, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c373t-e344143d56ea888fc101e8822d43a1f8724624efb80136576d92769d3089869b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adrenal Glands - drug effects</topic><topic>Adrenal Glands - pathology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cadmium</topic><topic>Cadmium - toxicity</topic><topic>Cadmium Poisoning - pathology</topic><topic>Cerebellum - drug effects</topic><topic>Cerebellum - pathology</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>General aspects</topic><topic>Health hazard</topic><topic>Hepatocytes - drug effects</topic><topic>Hepatocytes - pathology</topic><topic>Intoxication</topic><topic>Kidney Glomerulus - drug effects</topic><topic>Kidney Glomerulus - pathology</topic><topic>Kidney Tubules, Proximal - drug effects</topic><topic>Kidney Tubules, Proximal - pathology</topic><topic>Kupffer Cells - drug effects</topic><topic>Kupffer Cells - pathology</topic><topic>Liver - drug effects</topic><topic>Liver - pathology</topic><topic>Lung - drug effects</topic><topic>Lung - pathology</topic><topic>Medical sciences</topic><topic>Pathomorphology</topic><topic>Poisoning</topic><topic>Sheep</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stoev, Stoycho D.</creatorcontrib><creatorcontrib>Grozeva, N.</creatorcontrib><creatorcontrib>Simeonov, R.</creatorcontrib><creatorcontrib>Borisov, I.</creatorcontrib><creatorcontrib>Hubenov, H.</creatorcontrib><creatorcontrib>Nikolov, Y.</creatorcontrib><creatorcontrib>Tsaneva, M.</creatorcontrib><creatorcontrib>Lazarova, S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stoev, Stoycho D.</au><au>Grozeva, N.</au><au>Simeonov, R.</au><au>Borisov, I.</au><au>Hubenov, H.</au><au>Nikolov, Y.</au><au>Tsaneva, M.</au><au>Lazarova, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experimental cadmium poisoning in sheep</atitle><jtitle>Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie</jtitle><addtitle>Exp Toxicol Pathol</addtitle><date>2003-11-01</date><risdate>2003</risdate><volume>55</volume><issue>4</issue><spage>309</spage><epage>314</epage><pages>309-314</pages><issn>0940-2993</issn><eissn>1618-1433</eissn><abstract>Pathomorphological investigations of internal organs were made in sheep given sublethal doses of cadmium. Early histological damages in kidneys were established by renal biopsy in some experimental animals. The main histological changes were characterized by granular degeneration in proximal tubules and glomerular endothelial proliferation in kidneys, granular degeneration in hepatocytes, pericapillary oedema and activation of capillary endothelium and Kupffer cells in liver, oedematous and degenerative changes in cerebrum and in the region of Purkinje cells of cerebellum, hyperplasia and proliferation of alveolar epithelium and perivascular or peribronchial mononuclear cell infiltration in lung, and degenerative changes in the medulla and zona glomerulosa of adrenal glands.</abstract><cop>Jena</cop><pub>Elsevier GmbH</pub><pmid>14703778</pmid><doi>10.1078/0940-2993-00333</doi><tpages>6</tpages></addata></record> |
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| ispartof | Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie, 2003-11, Vol.55 (4), p.309-314 |
| issn | 0940-2993 1618-1433 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adrenal Glands - drug effects Adrenal Glands - pathology Animals Biological and medical sciences Cadmium Cadmium - toxicity Cadmium Poisoning - pathology Cerebellum - drug effects Cerebellum - pathology Chemical and industrial products toxicology. Toxic occupational diseases General aspects Health hazard Hepatocytes - drug effects Hepatocytes - pathology Intoxication Kidney Glomerulus - drug effects Kidney Glomerulus - pathology Kidney Tubules, Proximal - drug effects Kidney Tubules, Proximal - pathology Kupffer Cells - drug effects Kupffer Cells - pathology Liver - drug effects Liver - pathology Lung - drug effects Lung - pathology Medical sciences Pathomorphology Poisoning Sheep Toxicology |
| title | Experimental cadmium poisoning in sheep |
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