Species- and sex-specific variations in binding of ochratoxin A by renal proteins in vitro

The mycotoxin ochratoxin A (OTA) is a potent renal carcinogen in rodents and induces renal fibrosis in pigs. Furthermore, OTA has been associated with the development of renal tumors and nephropathies in humans. Large species- and sex-differences are observed in sensitivity toward OTA-mediated toxic...

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Veröffentlicht in:	Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2002-08, Vol.54 (2), p.151-159
Hauptverfasser:	Heussner, Alexandra H., O'Brien, Evelyn, Dietrich, Daniel R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anion Transport Proteins - pharmacology Binding Sites Binding, Competitive Biological and medical sciences Carcinogens - metabolism Humans Kidney - chemistry Kidney - drug effects Kidney - pathology Kidneys Medical sciences Mice Nephrology. Urinary tract diseases Ochratoxin A Ochratoxins - metabolism organic anion transporter Rats renal protein binding renal toxicity Sex Factors Swine Tumors of the urinary system
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