Acetaminophen hepatotoxicity and mechanisms of its protection by N-acetylcysteine: a study of Hep3B cells

Acetaminophen (AAP) hepatotoxicity, resulting in centrilobular necrosis, is frequently encountered following suicidal attempts, especially by adolescents, but also after its excessive use in infants. The subcellular and molecular sequences leading to hepatocellular cell death are not yet clear. We t...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2002, Vol.53 (6), p.489-500
Hauptverfasser:	Manov, Irena, Hirsh, Mark, Iancu, Theodore C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen Acetaminophen - antagonists & inhibitors Acetaminophen - toxicity Acetylcysteine - pharmacology Analgesics, Non-Narcotic - antagonists & inhibitors Analgesics, Non-Narcotic - toxicity apoptosis Apoptosis - drug effects Biological and medical sciences Carcinoma, Hepatocellular Cell Nucleus - drug effects Cell Nucleus - ultrastructure Cell Survival - drug effects Cytoplasm - drug effects Cytoplasm - ultrastructure Dose-Response Relationship, Drug Drug Antagonism Drug toxicity and drugs side effects treatment electron microscopy Flow Cytometry Free Radical Scavengers - pharmacology Glutathione - metabolism Hep3B cultured cells Hepatocytes - drug effects Hepatocytes - metabolism Hepatocytes - pathology hepatotoxicity Humans Liver Neoplasms Medical sciences N-acetylcysteine oxidative stress Oxidative Stress - drug effects Pharmacology. Drug treatments reactive oxygen species Reactive Oxygen Species - metabolism Toxicity: digestive system Tumor Cells, Cultured - drug effects Tumor Cells, Cultured - metabolism Tumor Cells, Cultured - pathology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!